Navigation Links
Texas A&M researchers develop tool to study complex clusters of genes
Date:7/2/2008

s of bacteria are different, how the genes in the operons are organized, and how the operons function.

Because of time and resource constraints, however, researchers cannot directly study in detail the genomes of all of the thousands of species of bacteria and can only carry out experiments on some of them, Sze explained. So researchers need a computational tool to help them predict where similar clusters of genes are in different species of bacteria so they can better focus their experiments, he said.

For each level of complexity in organisms, there is a model organism that scientists center their experiments on, and for bacteria, the model organism is E. coli. Because E. coli is a model organism, scientists have studied it in great detail and have a large amount of experimentally validated data on its genome and the operons that function, Sze said.

Sze and Yang's computational tool starts with a known and experimentally validated E. coli operon and then searches each of hundreds of separate species of bacteria for genes that are related to those in the E. coli operon. Once the tool has located related genes in a bacterium, it then checks to see if there is a strong clustering of the genes. It does this by using a statistical procedure that computes which genes are statistically very close to each other when you compare it to a random situation of genes, Sze explained.

"Imagine putting genes in a random order," Sze said. "When placed randomly, two specific genes are likely to be located at a far distance from each other. But if there is clustering, then the genes will be much closer to each other than they would be by chance."

So by using Sze and Yang's tool, scientists can easily locate sub-blocks of genes in different bacteria that are arranged in a similar fashion as one of the operons in E. coli. "If biologists are interested in a particular E. coli operon, they can use our tool to find where the operon is in the different bacteria," Sze
'/>"/>

Contact: Sing-Hoi Sze
shsze@tamu.edu
979-845-5009
Texas A&M University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Male seahorses are natures Mr. Mom, Texas A&M researchers say
2. Male seahorses are natures Mr. Mom, Texas A&M researchers say
3. UTMB inventions win University of Texas System commercialization awards
4. Underwater microscope helps prevent shellfish poisoning along Gulf Coast of Texas
5. Researchers confirm dead zone off Texas coast since 1985
6. Texas A&M scientists say early Americans arrived earlier
7. Texas A&M testing oral contraceptives for animals
8. Texas Hospital nations first to use large-scale cocoon strategy against whooping cough
9. Rices West honored as one of Texas best researchers
10. UT Southwestern scientist honored among best in Texas research
11. Gulf of Mexico dead zone to be studied by University of Texas at Austin marine scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/10/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ) has ... - NEC" report to their offering. ... to supply a range of IT security management and ... on the development of a Big Data and cloud ... Asia-Pacific region is a core ...
(Date:4/2/2015)... HAMBURG, Germany , April 2, 2015 /PRNewswire/ ... ten fingerprint tests DERMALOG by far outperforms the ... While always maintaining high accuracy, the system is ... second. Hence, the speed proves up to be ... 40% faster than its runner-up performance. ...
(Date:4/1/2015)... OXFORD, Conn. , Apr. 1, 2015  NXT-ID, ... a biometric authentication company focused on the growing mobile ... number of Wocket smart wallets is underway to early ... early access group includes usage at retail outlets including ... CVS Pharmacy. Users report Wocket was accepted at all ...
Breaking Biology News(10 mins):NEC Security Competitive Profile 2015 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4
... assumed that if mercury is high and increasing in fish ... true of fish elsewhere in the Arctic. But a ... discovered that assumption is wrong in much of the continental ... a result of diverse atmospheric, geological, and biological conditions, "It ...
... developed a new vaccine that protects against lethal pneumonia ... drug-resistant strains like MRSA. The research team was ... in the UI Carver College of Medicine. The findings ... Infectious Disease . The new vaccine targets toxins ...
... , a sprawling shrub that grows on just a single ... in its family and genus. It is also one of ... 200 million years ago. Now, researchers from Indiana University, with ... Penn State University, and the Institute of Research for Development ...
Cached Biology News:Virginia Tech research overturns assumption about mercury in the Arctic 2Virginia Tech research overturns assumption about mercury in the Arctic 3Staph stoppers 2A gluttonous plant reveals how its cellular power plant devours foreign DNA 2A gluttonous plant reveals how its cellular power plant devours foreign DNA 3
(Date:4/17/2015)... , April 17, 2015  US-Australian drug discovery company, ... Memorandum of Understanding with the Feinstein Institute for ... York to collaborate with the objective ... The collaboration brings together the drug discovery ... expertise of the Feinstein Institute in neurosciences and ...
(Date:4/16/2015)... OSAKA, Japan , April 16, 2015 ... of Kyoto University and Takeda Pharmaceutical Company Limited ... to develop clinical applications of induced pluripotent stem ... mellitus, neurological disorders and cancer immunotherapy. The "Takeda-CiRA ... designed to expedite multiple research projects for drug ...
(Date:4/16/2015)... April 16, 2015  Schulman Associates IRB, Inc., the ... signed a long-term lease on Laboratory Drive in the ... . The location will house review board and ... high quality reviews and customer service to clients. ... represented Schulman in the deal, while Capital Associates Management, ...
(Date:4/16/2015)... , April 16, 2015  In recognition of World ... with hemophilia advocacy groups to illuminate more than 15 prominent ... including Boston,s Zakim Bridge and Prudential ... New Orleans, Mercedes-Benz Superdome and Denver,s ... during the evening of April 17, and coincide with hemophilia ...
Breaking Biology Technology:Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 2Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 3Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 4Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 5Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 6CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 2CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 3Schulman IRB to Open Office in Research Triangle Park, N.C. 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 3Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 4
... with its goal of extending electronic government and ... how such a massive undertaking can take place ... sharing information and integrating systems has been clear ... , ,What has been missing is the organizational ...
... carefully established position as a nexus for research and development ... academic and other research institutions, according to a new report. ... This prediction comes from the Wisconsin Technology Council ... report, titled The Economic Value of Academic Research and Development ...
... Institutes of Health. Madison, Wis. ... Wednesday that it will receive a $1.26 million Phase II ... Health. , ,The funds will be used to help produce ... disorder that kills red blood cells. This results in a ...
Cached Biology Technology:State CIO wants to unify electronic government 2State CIO wants to unify electronic government 3State CIO wants to unify electronic government 4Economic report raises red flags on Wisconsin's future 2Economic report raises red flags on Wisconsin's future 3Mirus receives $1.26 million SBIR grant to combat anemia 2
...
... The Luminex 200 IS System is ideal ... Upstate's Beadlyte reagents. This system contains the ... developed by Luminex. The user can design ... kits. The system has fully integrated graphing ...
... Quality ISO 9001:2000 Certified USDA Research ... Validated, SOP's Training AALAS Certified ... All Procedures GLP Documentation Upon Request ... shopping point for all your custom immunology ...
... Re-Blot Western Blot Recycling Kit is ... Western blots that have been developed ... other isotopes. It is not recommended ... 4-chloronapthol, etc.), as it is not ...
Biology Products: