Navigation Links
Texas A&M researchers develop tool to study complex clusters of genes
Date:7/2/2008

s of bacteria are different, how the genes in the operons are organized, and how the operons function.

Because of time and resource constraints, however, researchers cannot directly study in detail the genomes of all of the thousands of species of bacteria and can only carry out experiments on some of them, Sze explained. So researchers need a computational tool to help them predict where similar clusters of genes are in different species of bacteria so they can better focus their experiments, he said.

For each level of complexity in organisms, there is a model organism that scientists center their experiments on, and for bacteria, the model organism is E. coli. Because E. coli is a model organism, scientists have studied it in great detail and have a large amount of experimentally validated data on its genome and the operons that function, Sze said.

Sze and Yang's computational tool starts with a known and experimentally validated E. coli operon and then searches each of hundreds of separate species of bacteria for genes that are related to those in the E. coli operon. Once the tool has located related genes in a bacterium, it then checks to see if there is a strong clustering of the genes. It does this by using a statistical procedure that computes which genes are statistically very close to each other when you compare it to a random situation of genes, Sze explained.

"Imagine putting genes in a random order," Sze said. "When placed randomly, two specific genes are likely to be located at a far distance from each other. But if there is clustering, then the genes will be much closer to each other than they would be by chance."

So by using Sze and Yang's tool, scientists can easily locate sub-blocks of genes in different bacteria that are arranged in a similar fashion as one of the operons in E. coli. "If biologists are interested in a particular E. coli operon, they can use our tool to find where the operon is in the different bacteria," Sze
'/>"/>

Contact: Sing-Hoi Sze
shsze@tamu.edu
979-845-5009
Texas A&M University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Male seahorses are natures Mr. Mom, Texas A&M researchers say
2. Male seahorses are natures Mr. Mom, Texas A&M researchers say
3. UTMB inventions win University of Texas System commercialization awards
4. Underwater microscope helps prevent shellfish poisoning along Gulf Coast of Texas
5. Researchers confirm dead zone off Texas coast since 1985
6. Texas A&M scientists say early Americans arrived earlier
7. Texas A&M testing oral contraceptives for animals
8. Texas Hospital nations first to use large-scale cocoon strategy against whooping cough
9. Rices West honored as one of Texas best researchers
10. UT Southwestern scientist honored among best in Texas research
11. Gulf of Mexico dead zone to be studied by University of Texas at Austin marine scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 16, 2014 Research and Markets ... the "Global Chemical Sensor Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 One major trend ... for medical sensors in biomedical applications. Chemical sensors ... and correct diagnosis during surgical procedures. The Global ...
(Date:12/15/2014)... 12, 2014 Research and Markets ... the "Global Facial Recognition Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition is ... Facial recognition system measures the overall facial feature ... mouth, and the distance between eyes. Facial recognition ...
(Date:12/11/2014)... Research and Markets , ... http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition of the ... to their offering. One major ... of multimodal biometric systems. Multimodal biometric systems utilize ... verification and identification purposes. This helps to reduce ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... New Rochelle, NY, April 3, 2009A novel technique ... challenge the market dominance of the current, widely ... News ( GEN ). Some scientists believe ... for gene-expression analysis, will eventually rival microarrays in ...
... the 82-ton-force, earthquake-simulation shake table could not knock down ... Nevada, Reno alumna and civil engineer Darcey Donovan. ... foundation and clay plaster walls, the way she builds ... acceleration/shaking than was recorded at the 1994 Northridge, Calif. ...
... allergy may be malfunction of the respiratory epithelium, which ... the epithelium. Two studies by Finnish research groups on ... biomedical journals (1) Allergy , and (2) ... Research on the mechanisms of allergy has focused on ...
Cached Biology News:Straw bale house survives violent shaking at earthquake lab 2Straw bale house survives violent shaking at earthquake lab 3Malfunction of the respiratory epithelium is a cause of allergy? 2
(Date:12/17/2014)... (PRWEB) December 17, 2014 Xeno ... Excellence following its most recent COLA inspection. Xeno ... COLA, a national healthcare accreditation organization. Accreditation is ... of quality in day-to-day operations, demonstrate continued accuracy ... a rigorous on-site laboratory survey. , ...
(Date:12/17/2014)... , Dec. 16, 2014  Vermillion, Inc. (NASDAQ: ... on gynecologic disease, today announced the next step in ... premier bio-analytics solutions provider with the naming of current ... and Chief Executive Officer, while current Chairman of the ... to serve as Chairman. These changes are effective January ...
(Date:12/17/2014)... SAN FRANCISCO, Calif. , Dec. 17, 2014 ... results of a Phase 2 study evaluating the ... the treatment of patients with severe, chronic itch ... current standard of care, including topical steroids and ... was percent change in Visual Analog Scale (VAS) ...
(Date:12/15/2014)... & PETACH TIKVAH, Israel ... (NASDAQ: BCLI ), a leading developer of ... that wholly-owned subsidiary Brainstorm Cell Therapeutics Ltd. was awarded ... Israel,s Office of the Chief Scientist (OCS).  ... in receipt of grant support from the Office of ...
Breaking Biology Technology:Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 3Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 4Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 2BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 3
... trend toward miniaturization, carbon nanotubes which are about ... several unique and very useful properties have become ... nanosized electronic and mechanical devices. But it is precisely ... clump together, that make it difficult for scientists to ...
... and ... excellent value, BOSTON, May ... and medical image and information management solutions,today announced that it has ... use MEDITECH(TM) as their health,information system. AMICAS will be showcasing Vision ...
... industry to benefit ... recruitment efforts, MINNEAPOLIS, May 27 Leading ... strengthened the,pharmaceutical side of its business with the ... commitment to leveraging differentiators unique,to the medical device ...
Cached Biology Technology:Weizmann Institute scientists create new nanotube structures 2AMICAS Announces Integrations at More Than 100 MEDITECH Facilities 2AMICAS Announces Integrations at More Than 100 MEDITECH Facilities 3ThreeWire Expands Presence in the Pharmaceutical Arena 2