Navigation Links
Texas A&M research produces tools to study stallions' subfertility
Date:8/26/2010

COLLEGE STATION, Aug. 26, 2010 Subfertility of breeding stallions meaning the horses are less able to sire foals is a well-recognized problem that has caused multi-million-dollar losses in the equine industry, experts say. Texas A&M researchers believe they are making progress in solving the problem by using an approach that might provide tools and resources necessary to study subfertility without causing stallions the angst of providing testicular samples for testing.

They have developed protocols to isolate RNAwhich carries the information of genes in DNA from stallion sperm and testis biopsies so that genetic factors associated with this condition can be identified.

Researchers from the Departments of Veterinary Integrative Biosciences (VIBS) and Large Animal Clinical Sciences had their results published online in the journal Theriogenology. The leading author of the published research is Dr. Terje Raudsepp, an assistant professor from VIBS, and the first author is Dr. Pranab J. Das, a postdoctoral research assistant from the same department.

The RNA isolation technique from stallion sperm is believed to lead to the discovery of fertility biomarkers that could improve breeding procedures and raise thoroughbred race horses.

"Because of the structure of horse breeding, where one stallion covers many mares, the economy of the breeding industry is more sensitive to the fertility of the stallion than the mare," Das says.

"During past decades, several organized studies have been conducted to understand the role of various environmental, behavioral and physiological factors affecting fertility in horses," adds Raudsepp, the project leader. "However, very little is known about the genetic factors associated with stallion fertility, and genetic factors of male fertility involve the interplay of hundreds of genes."

Obtaining testis tissue by surgery could harm the horse, so the research team studied an alternative RNA isolation from sperm which is non-invasive.

But RNA isolation from sperm has several challenges, the researchers say. "RNA quantity in a sperm cell is low, and sperm are highly condensed cells," they explain.

The Texas A&M team overcame these challenges and developed protocols that are specific to the species and to the various sources of sperm, including fresh ejaculates, flash frozen, cooled ejaculates and others.

"The team has started to identify the genes whose messengers are present in stallion sperm and to associate these genes with known fertility issues and sperm functions," the researchers say. "This knowledge is necessary for the next stage of research, which aims to identify differences in gene profiles between normal and subfertile or infertile stallions.

"Now, breeding stallions are selected mainly on the basis of their pedigree, looks and performance," the researchers add. "But in the future, we may be able to select them based on their reproductive potential. The published paper on RNA isolation from stallion sperm sets a necessary foundation to initiate these studies."


'/>"/>

Contact: Keith Randall
keith-randall@tamu.edu
979-845-4644
Texas A&M University
Source:Eurekalert

Related biology news :

1. A river flipped: Humans trump nature on Texas river
2. Texas petrochemical emissions down, but still underestimated, says study
3. Texas A&M spring graduate contributes to mental retardation research published in Nature
4. Chances of hurricane hitting Texas discussed at UH conference
5. Texas A&M veterinary researchers achieve cloning first
6. Texas Childrens Hospital vaccine experts present 4 studies
7. New bony-skulled dinosaur species discovered in Texas
8. Texas Childrens Cancer Center first in Texas to magnetically lengthen nine-year-olds leg as she grows
9. UT Southwesterns BioCenter driving biotech, medical innovation in North Texas
10. Biogas technology with potential to save thousands of lives to be featured at Texas event
11. Quickly and easily integrate fingerprint biometric features into portable applications with Texas Instruments comprehensive, low cost fingerprint development kit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/9/2017)... MOUNTAIN VIEW, Calif. , March 9, 2017 ... and 23andMe , the leading personal genetics company, ... Zipongo can now provide customers with personalized nutrition plans ... and biometrics, but also genetic markers impacting how their ... Zipongo,s personalized food decision support platform uses biometrics such ...
(Date:3/7/2017)...   HireVue , the leading provider of video ... best talent, faster, today announced the additions of ... Diana Kucer as Chief Marketing Officer (CMO). ... poised to drive continued growth in the company,s new ... record bookings in 2017. "Companies worldwide turn ...
(Date:3/2/2017)... Summary This report provides all the ... interests and activities since 2010. ... Read the full report: http://www.reportlinker.com/p03605615-summary/view-report.html ... report provides an in-depth insight into the partnering activity of ... On demand company reports are prepared upon purchase to ensure ...
Breaking Biology News(10 mins):
(Date:3/24/2017)... 24, 2017 Agenus Inc. (NASDAQ: AGEN), an ... and cancer vaccines, today announced participation at the following ... William Blair and Maidstone Life Sciences conference "Cancer Immunotherapy ... New York, NY . Agenus will ... at 9:40 am: Robert B. Stein , M.D., ...
(Date:3/23/2017)... Mar 23, 2017 Research and Markets ... Markets" report to their offering. ... The Global Market for ... in 2016 at a CAGR of 8.9%, ... non-energetic bioproducts into seven major product segments: bio-derived chemicals, biofuels, ...
(Date:3/23/2017)...  GlobeImmune, Inc. today announced it has entered into ... shares of its common stock to NantCell, Inc., a ... the sale of its common stock, NantCell has agreed ... GlobeImmune 200,000 shares, an estimated $2.0 million in value, ... pleased to enter into this strategic agreement with NantCell," ...
(Date:3/23/2017)... March 23, 2017 Kineta, Inc., a ... novel therapies in immuno-oncology, today announced the discovery ... molecule compounds that activate interferon response factor 3 ... demonstrate immune-mediated tumor regression in a murine colon ... who demonstrated complete tumor regression to initial drug ...
Breaking Biology Technology: