Navigation Links
Texas A&M research produces tools to study stallions' subfertility
Date:8/26/2010

COLLEGE STATION, Aug. 26, 2010 Subfertility of breeding stallions meaning the horses are less able to sire foals is a well-recognized problem that has caused multi-million-dollar losses in the equine industry, experts say. Texas A&M researchers believe they are making progress in solving the problem by using an approach that might provide tools and resources necessary to study subfertility without causing stallions the angst of providing testicular samples for testing.

They have developed protocols to isolate RNAwhich carries the information of genes in DNA from stallion sperm and testis biopsies so that genetic factors associated with this condition can be identified.

Researchers from the Departments of Veterinary Integrative Biosciences (VIBS) and Large Animal Clinical Sciences had their results published online in the journal Theriogenology. The leading author of the published research is Dr. Terje Raudsepp, an assistant professor from VIBS, and the first author is Dr. Pranab J. Das, a postdoctoral research assistant from the same department.

The RNA isolation technique from stallion sperm is believed to lead to the discovery of fertility biomarkers that could improve breeding procedures and raise thoroughbred race horses.

"Because of the structure of horse breeding, where one stallion covers many mares, the economy of the breeding industry is more sensitive to the fertility of the stallion than the mare," Das says.

"During past decades, several organized studies have been conducted to understand the role of various environmental, behavioral and physiological factors affecting fertility in horses," adds Raudsepp, the project leader. "However, very little is known about the genetic factors associated with stallion fertility, and genetic factors of male fertility involve the interplay of hundreds of genes."

Obtaining testis tissue by surgery could harm the horse, so the research team studied an alternative RNA isolation from sperm which is non-invasive.

But RNA isolation from sperm has several challenges, the researchers say. "RNA quantity in a sperm cell is low, and sperm are highly condensed cells," they explain.

The Texas A&M team overcame these challenges and developed protocols that are specific to the species and to the various sources of sperm, including fresh ejaculates, flash frozen, cooled ejaculates and others.

"The team has started to identify the genes whose messengers are present in stallion sperm and to associate these genes with known fertility issues and sperm functions," the researchers say. "This knowledge is necessary for the next stage of research, which aims to identify differences in gene profiles between normal and subfertile or infertile stallions.

"Now, breeding stallions are selected mainly on the basis of their pedigree, looks and performance," the researchers add. "But in the future, we may be able to select them based on their reproductive potential. The published paper on RNA isolation from stallion sperm sets a necessary foundation to initiate these studies."


'/>"/>

Contact: Keith Randall
keith-randall@tamu.edu
979-845-4644
Texas A&M University
Source:Eurekalert

Related biology news :

1. A river flipped: Humans trump nature on Texas river
2. Texas petrochemical emissions down, but still underestimated, says study
3. Texas A&M spring graduate contributes to mental retardation research published in Nature
4. Chances of hurricane hitting Texas discussed at UH conference
5. Texas A&M veterinary researchers achieve cloning first
6. Texas Childrens Hospital vaccine experts present 4 studies
7. New bony-skulled dinosaur species discovered in Texas
8. Texas Childrens Cancer Center first in Texas to magnetically lengthen nine-year-olds leg as she grows
9. UT Southwesterns BioCenter driving biotech, medical innovation in North Texas
10. Biogas technology with potential to save thousands of lives to be featured at Texas event
11. Quickly and easily integrate fingerprint biometric features into portable applications with Texas Instruments comprehensive, low cost fingerprint development kit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/1/2016)... Feb. 1, 2016  Wocket® smart wallet ( www.wocketwallet.com ) announces the ... Joey Fatone . Las Vegas , where ... --> Las Vegas , where Joey appeared at ... The new video ad was filmed at the Consumer Electronics Show (CES2016) ... Wocket booth to meet and greet fans. --> ...
(Date:1/25/2016)... , Jan. 25, 2016   Unisys Corporation (NYSE: ... at John F. Kennedy (JFK) International Airport, New York ... (CBP) identify imposters attempting to enter the United ... belong to them. pilot testing of the system ... at three terminals at JFK during January 2016. --> ...
(Date:1/22/2016)... http://www.researchandmarkets.com/research/p74whf/global_biometrics ) ... "Global Biometrics Market in Retail Sector 2016-2020" ... --> http://www.researchandmarkets.com/research/p74whf/global_biometrics ) has announced the ... in Retail Sector 2016-2020" report to ... and Markets ( http://www.researchandmarkets.com/research/p74whf/global_biometrics ) has announced ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... , Febr. 10, 2016 /PRNewswire/ - BioAmber Inc. (NYSE: ... to announce that Mitsui & Co. Ltd., its partner ... acid plant, is investing an additional CDN$25 million in ... its stake from 30% to 40%.  Mitsui will also ... acid produced in Sarnia , providing ...
(Date:2/10/2016)... -- The Maryland House of Delegates and House Speaker ... Maryland School of Medicine Dean E. Albert Reece ... System President and CEO Robert Chrencik , MBA, ... given to the public by the leader of the ... and Mr. Chrencik for their contributions to our statewide ...
(Date:2/10/2016)... -- ASAE is introducing a hybrid membership model which ... option of joining or renewing through an organizational purchasing ... size, every employee in any size association or AMC ... available member benefits.   John H. Graham, ... will allow organizations of any size and their employees ...
(Date:2/10/2016)... (NYSE MKT: ISR), a medical technology company and innovator ... treatment of prostate, brain, lung, head and neck and ... second quarter and six months of fiscal 2016, which ... --> Revenue was $1.19 million for ... 31, 2015, a 12% increase compared to $1.07 million ...
Breaking Biology Technology: