Navigation Links
Texas A&M research produces tools to study stallions' subfertility
Date:8/26/2010

COLLEGE STATION, Aug. 26, 2010 Subfertility of breeding stallions meaning the horses are less able to sire foals is a well-recognized problem that has caused multi-million-dollar losses in the equine industry, experts say. Texas A&M researchers believe they are making progress in solving the problem by using an approach that might provide tools and resources necessary to study subfertility without causing stallions the angst of providing testicular samples for testing.

They have developed protocols to isolate RNAwhich carries the information of genes in DNA from stallion sperm and testis biopsies so that genetic factors associated with this condition can be identified.

Researchers from the Departments of Veterinary Integrative Biosciences (VIBS) and Large Animal Clinical Sciences had their results published online in the journal Theriogenology. The leading author of the published research is Dr. Terje Raudsepp, an assistant professor from VIBS, and the first author is Dr. Pranab J. Das, a postdoctoral research assistant from the same department.

The RNA isolation technique from stallion sperm is believed to lead to the discovery of fertility biomarkers that could improve breeding procedures and raise thoroughbred race horses.

"Because of the structure of horse breeding, where one stallion covers many mares, the economy of the breeding industry is more sensitive to the fertility of the stallion than the mare," Das says.

"During past decades, several organized studies have been conducted to understand the role of various environmental, behavioral and physiological factors affecting fertility in horses," adds Raudsepp, the project leader. "However, very little is known about the genetic factors associated with stallion fertility, and genetic factors of male fertility involve the interplay of hundreds of genes."

Obtaining testis tissue by surgery could harm the horse, so the research team studied an alternative RNA isolation from sperm which is non-invasive.

But RNA isolation from sperm has several challenges, the researchers say. "RNA quantity in a sperm cell is low, and sperm are highly condensed cells," they explain.

The Texas A&M team overcame these challenges and developed protocols that are specific to the species and to the various sources of sperm, including fresh ejaculates, flash frozen, cooled ejaculates and others.

"The team has started to identify the genes whose messengers are present in stallion sperm and to associate these genes with known fertility issues and sperm functions," the researchers say. "This knowledge is necessary for the next stage of research, which aims to identify differences in gene profiles between normal and subfertile or infertile stallions.

"Now, breeding stallions are selected mainly on the basis of their pedigree, looks and performance," the researchers add. "But in the future, we may be able to select them based on their reproductive potential. The published paper on RNA isolation from stallion sperm sets a necessary foundation to initiate these studies."


'/>"/>

Contact: Keith Randall
keith-randall@tamu.edu
979-845-4644
Texas A&M University
Source:Eurekalert

Related biology news :

1. A river flipped: Humans trump nature on Texas river
2. Texas petrochemical emissions down, but still underestimated, says study
3. Texas A&M spring graduate contributes to mental retardation research published in Nature
4. Chances of hurricane hitting Texas discussed at UH conference
5. Texas A&M veterinary researchers achieve cloning first
6. Texas Childrens Hospital vaccine experts present 4 studies
7. New bony-skulled dinosaur species discovered in Texas
8. Texas Childrens Cancer Center first in Texas to magnetically lengthen nine-year-olds leg as she grows
9. UT Southwesterns BioCenter driving biotech, medical innovation in North Texas
10. Biogas technology with potential to save thousands of lives to be featured at Texas event
11. Quickly and easily integrate fingerprint biometric features into portable applications with Texas Instruments comprehensive, low cost fingerprint development kit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/4/2017)... -- For the thousands of attendees at this year,s International Consumer Electronics Show ... biometric measurement devices and services, will be featuring its new line of ... Medical,s special CES Exhibit Suite , the new upper arm and ... WellnessConnected product platform.  Continue ... ...
(Date:12/22/2016)... Calif. , Dec. 20, 2016  As part of ... 23andMe, the leading personal genetics company, recently released its latest ... . The book focuses on the topics of inheritance ... Generation Science Standards (NGSS) taught in elementary school classrooms in ... in a series by illustrator Ariana Killoran , whose ...
(Date:12/20/2016)... 2016   Valencell , the leading innovator ... STMicroelectronics (NYSE: STM), a global semiconductor leader serving ... today the launch of a new, highly accurate ... includes ST,s compact SensorTile turnkey multi-sensor ... sensor system. Together, SensorTile and Benchmark deliver the ...
Breaking Biology News(10 mins):
(Date:1/23/2017)... FORT LAUDERDALE, Fl (PRWEB) , ... January 23, ... ... Commission Accredited venture-backed teleradiology and telemedicine company announces significant growth last year adding ... customers include Veterans Authority and US Army medical centers as well as one ...
(Date:1/23/2017)... ... January 23, 2017 , ... ... appointed Vice President, Preclinical Safety and Senior Director, Safety Pharmacology. Dr. Thomas ... India. , Dr. Thomas’ career as an academic and industry preclinical drug ...
(Date:1/21/2017)... ... January 20, 2017 , ... Nipro Corporation (Osaka, Japan) and Transonic Systems ... Nipro will receive exclusive marketing and sales rights for all non-OEM Transonic products in ... patients in Japan, the new Nipro - Transonic JV is a natural next step ...
(Date:1/21/2017)... Jan. 21, 2017   Boston Biomedical , an ... to target cancer stemness pathways, today presented data from ... at the 2017 American Society of Clinical Oncology (ASCO) ... . In a Phase Ib/II study ... to inhibit cancer stemness pathways by targeting STAT3 – ...
Breaking Biology Technology: