Navigation Links
Texas A&M chemical engineer's work could lead to improved DNA analysis
Date:9/9/2010

COLLEGE STATION, Sept. 9, 2010 DNA analysis is poised to experience a significant advancement thanks to the work of a Texas A&M University chemical engineer, who has discovered a way to achieve more effective separation of DNA fragments.

Working with a widely used gelatin substance known as a hydrogel, Victor M. Ugaz, associate professor in the university's Artie McFerrin Department of Chemical Engineering, and graduate student Nan Shi have been able to determine the specific type of conditions that result in the optimum gel pore structure for separation of a wide range of DNA fragment sizes. Their findings appear in the Sept. 3 edition of the journal Physical Review Letters.

"It changes the way you think about the entire process because these findings demonstrate a rational way to connect the pore structure of the gel quantitatively to the mechanism by which the DNA moves through the gel," Ugaz explains. "Researchers can now actually design gels to specifically harness certain effects, and they will need this information we have found to do that."

The enhanced separation technique, Ugaz notes, could benefit a wide array of fields that utilize DNA analysis, including biomedical research, forensics and genetic engineering.

Key to Ugaz's findings is the manner in which DNA fragments move through a hydrogel. Employing a process called "electrophoresis," researchers who study DNA typically embed negatively charged DNA into a porous hydrogel. They then apply an electric field which causes the DNA fragments to move through the pores of the hydrogel. Naturally, smaller DNA chains move faster through the maze of pores than longer strands of DNA.

However, when DNA chains are roughly the same size as the pores through which they are attempting to pass, a process called "entropic trapping" takes place, Ugaz notes. During this process, the naturally coiled DNA fragment, in a sense, has to unthread a bit to pass through a pore
'/>"/>

Contact: Ryan Garcia
ryan.garcia99@tamu.edu
979-845-9237
Texas A&M University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Earth scientists keep an eye on Texas
2. 7 Texas mammals listed as threatened on Global Mammal Assessment
3. Texas A&M anthropologist discovers long-lost primate in Indonesia
4. Texas invests record $3.5 million in startup cofounded by UTs Mauro Ferrari
5. Texas College Police Unit Deploys BIO-key(R) Mobile Data System
6. UT Southwestern scientist honored among best in Texas research
7. Texas Medical Center researchers win collaborative grants
8. Famous fossil Lucy scanned at the University of Texas at Austin
9. Texas researchers provide emissions data for livestock industry
10. Texas Obesity Research Center at UH assembles researchers to discuss obesity
11. Texas-sized tract of single-celled clones
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... November 18, 2014 According to ... by Systems (Video, RFID, Access Control, Intrusion Detection, Parking ... Banks, Government), Component Service Geography - Global Forecasts to ... is projected to be around $25 Billion in 2014 ... growing at a CAGR of 8.69%. Browse ...
(Date:11/18/2014)... -- The Secure Identity & Biometrics Association (SIBA) and ... formation of The Airport Entry and Exit Working ... Biometric Entry and Exit Solutions Framework for Airports ... BORDERPOL, the international non-profit organization that works directly ... border security, traveler and migration systems. ...
(Date:11/12/2014)... PALM BEACH GARDENS, Fla. , Nov. 12, 2014 ... management solutions, announced today that its U.are.U ® ... upscale retail bakery chain in Central Mexico ... solution in June 2014 to eliminate payroll issues caused ... Prior to installing the U.are.U fingerprint readers, Montparnasse ...
Breaking Biology News(10 mins):Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2
... EAST LANSING, Mich. -- Scientists have identified how a single ... A team of scientists from Michigan State University and ... the results in the current issue of Biology Letters ... development, plays a crucial role in the evolution of bees, ...
... January 2014: The Medical Research Council (MRC) Centre for Drug ... million pounds of new funding from MRC to allow it ... drugs. Adverse drug reactions result in one in 15 ... million every year. They are also a significant cause of ...
... of genes within a cell) is a crucial process ... protein synthesis, whereby the single amino acids, the "building ... strung together like beads on a necklace. Even though ... "stochastic" aspects had been neglected: in the chain of ...
Cached Biology News:Single gene separates queen from workers 2£3m drug safety center investment 2Protein synthesis and chance 2Protein synthesis and chance 3
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... of Norcoss, Ga., will offer the Microsoft Education Services of ... in the metro Atlanta area, the two companies announced Tuesday. ... of public classes from end user applications to technical courses, ... Michael's Hospital in Stevens Point and Saint Clare's ...
... As more organizations look at what needs to be ... an area that has come under the spotlight is ... corporate governance issues have become issues even within the ... Act (SOX) has become a reason to organize and ...
... Douglas Stewart Co., a provider of software and ... Mindjet Corp. to distribute Mindjet's new MindManager ... than 4,500 academic resellers and 150 college stores in ... Stewart Co., based in Madison, is the largest distributor ...
Cached Biology Technology:Tech Digest: Inacom; St. Michael's, St. Clare's hospitals; Merge eMed; Advanced Data-Comm; Blue Cross and Blue Shield 2Sarbox necessitating ECM software, but beware of `best practices' 2Sarbox necessitating ECM software, but beware of `best practices' 3
... system, 220-240 V, is used for nucleic acid ... slab gel format. The system includes the modular ... separating nucleic acids with single base-pair resolution and ... and bonded inner glass plate, outer glass plate, ...
... PowerPac HV high-voltage power supply, with temperature probe, ... of 5,000 V, 500 mA, and 400 W. ... temperature between 0 and 90 degrees C during ... transfer. Power cord and instructions are provided. Dimensions ...
... cooling coil, Trans-Blot cell, provides ... high-intensity, and extended electrophoretic transfer ... Trans-Blot cell. Use of the ... to an external water recirculator, ...
... By incorporating a wide range of next-generation ... sets a new standard for flexible laboratory ... handling including pipetting, dilution, dispensing, and ... thats as powerful and flexible as it ...
Biology Products: