Navigation Links
Texas A&M chemical engineer's work could lead to improved DNA analysis
Date:9/9/2010

COLLEGE STATION, Sept. 9, 2010 DNA analysis is poised to experience a significant advancement thanks to the work of a Texas A&M University chemical engineer, who has discovered a way to achieve more effective separation of DNA fragments.

Working with a widely used gelatin substance known as a hydrogel, Victor M. Ugaz, associate professor in the university's Artie McFerrin Department of Chemical Engineering, and graduate student Nan Shi have been able to determine the specific type of conditions that result in the optimum gel pore structure for separation of a wide range of DNA fragment sizes. Their findings appear in the Sept. 3 edition of the journal Physical Review Letters.

"It changes the way you think about the entire process because these findings demonstrate a rational way to connect the pore structure of the gel quantitatively to the mechanism by which the DNA moves through the gel," Ugaz explains. "Researchers can now actually design gels to specifically harness certain effects, and they will need this information we have found to do that."

The enhanced separation technique, Ugaz notes, could benefit a wide array of fields that utilize DNA analysis, including biomedical research, forensics and genetic engineering.

Key to Ugaz's findings is the manner in which DNA fragments move through a hydrogel. Employing a process called "electrophoresis," researchers who study DNA typically embed negatively charged DNA into a porous hydrogel. They then apply an electric field which causes the DNA fragments to move through the pores of the hydrogel. Naturally, smaller DNA chains move faster through the maze of pores than longer strands of DNA.

However, when DNA chains are roughly the same size as the pores through which they are attempting to pass, a process called "entropic trapping" takes place, Ugaz notes. During this process, the naturally coiled DNA fragment, in a sense, has to unthread a bit to pass through a pore
'/>"/>

Contact: Ryan Garcia
ryan.garcia99@tamu.edu
979-845-9237
Texas A&M University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Earth scientists keep an eye on Texas
2. 7 Texas mammals listed as threatened on Global Mammal Assessment
3. Texas A&M anthropologist discovers long-lost primate in Indonesia
4. Texas invests record $3.5 million in startup cofounded by UTs Mauro Ferrari
5. Texas College Police Unit Deploys BIO-key(R) Mobile Data System
6. UT Southwestern scientist honored among best in Texas research
7. Texas Medical Center researchers win collaborative grants
8. Famous fossil Lucy scanned at the University of Texas at Austin
9. Texas researchers provide emissions data for livestock industry
10. Texas Obesity Research Center at UH assembles researchers to discuss obesity
11. Texas-sized tract of single-celled clones
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... 31 juillet 2015 La 10e Conférence ... sera organisée par le BGI du 22 au ... en Chine. La conférence célèbre ... en 2006, l,ICG est devenue l,une des réunions ... des « omiques » et c,est aussi la plus dynamique, ...
(Date:7/31/2015)... Conn. , Jul. 31, 2015 NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... that it has filed provisional patent 62/198989 for ... This invention highlights a method to advance crypto-currencies such ... by introducing a common, uniform way to manage all ...
(Date:7/27/2015)... , July 27, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced that Huawei has selected ... solution for its stylish smartwatch. Huawei chose the ... reliability, low power and highly responsive human interface ... Huawei designers also required a classic round watch ...
Breaking Biology News(10 mins):La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3
... ability to reduce cholesterol, but a research report appearing in ... Biology ( http://www.jleukbio.org ) shows that these same drugs ... lung damage resulting from severe abdominal sepsis and infection. ... knowledge about the complicated pathophysiology behind abdominal sepsis, but also ...
... When schools cut physical education programs so students can ... a golden opportunity to promote learning, according to research to ... (PAS) annual meeting in Denver. The study adds ... the body but also the mind. It also shows that ...
... disasters can affect children,s health in unique ways, both physically ... annual meeting at the Colorado Convention Center in Denver, Colo., ... will examine the toll of two recent disasters on children,s ... and the 2010 Gulf of Mexico oil spill. ...
Cached Biology News:Statins may stave off septic lung damage says new research study 2Movement + academics = success 2Pediatricians examine impact of environmental disasters on children's health 2
(Date:8/28/2015)... ... , ... Since the initial launch of FireflySci Inc. (FFS) in early 2015, the company continues ... Images such as the Fonz in a lab coat and Large Marge have been posted ... field. , FireflySci is proud to be the only cuvette manufacturer is the ...
(Date:8/27/2015)... - Portage Biotech Inc. ("Portage") (OTC Market: PTGEF, ... Company Limited (Biohaven), announced today that dosing has ... a glutamate modulating agent. Biohaven filed an investigational ... clearance from the U.S. Food and Drug Administration ... 54% equity interest in Biohaven, a private company. ...
(Date:8/27/2015)... Aug. 27, 2015 HUYA Bioscience International (HUYA) today ... the Japan Society of HTLV-1, held this week at ... purpose of the Society is to promote research on ... of medical technology and research related to these fields ... "HUYA is proud to support this prestigious conference," ...
(Date:8/27/2015)... Aug. 27, 2015 In response to ... UPS and The US Postal Service to no ... as ,select agents, by the CDC, Marken reaffirmed ... these sensitive shipments. Marken uses its ... trained and certified personnel to ensure the safe ...
Breaking Biology Technology:Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4Marken Ensures Safe Transportation Of Select Agents And Toxins 2
... Mich., Sept. 27 Neogen Corporation,(Nasdaq: NEOG ) ... quarter of,FY 2008, which ended Aug. 31, increased 25% ... a 3-for-2 stock split, net income per,share was $0.21 ... for the,same period in the prior year. First ...
... provides additional treatment option for asthma patients not fully ... ... NAPA, Calif., Sept. 27 Dey, L.P., an,affiliate of Merck ... (zileuton) extended-release tablets with its,marketing partner, Critical Therapeutics, Inc. (Nasdaq: ...
... Systems (NYSE: VAR ) and one of ... IGRT (image guided radiotherapy),training school, enabling hospitals across ... most precise radiotherapy technologies available to radiation,oncologists. ... the venue for,the first event of its kind, ...
Cached Biology Technology:Neogen Reports 25% Increase in Net Income, 13% Increase in Revenues 2Neogen Reports 25% Increase in Net Income, 13% Increase in Revenues 3Neogen Reports 25% Increase in Net Income, 13% Increase in Revenues 4Neogen Reports 25% Increase in Net Income, 13% Increase in Revenues 5Dey L.P. and Critical Therapeutics Launch Twice-Daily ZYFLO CR(TM) (Zileuton) Extended-Release Tablets for the Chronic Treatment of Asthma 2Dey L.P. and Critical Therapeutics Launch Twice-Daily ZYFLO CR(TM) (Zileuton) Extended-Release Tablets for the Chronic Treatment of Asthma 3First European IGRT School Takes Place for Radiotherapy Practitioners in UK 2First European IGRT School Takes Place for Radiotherapy Practitioners in UK 3
... benchtop ductless exhaust hood ventilates and ... indoor release of exhaust. Bonded charcoal ... 28" of vertical clearance (with access ... polypropylene spill tray; options include final ...
...
... These versatile enclosures are ... nitrogen or other process ... low-humidity environment. HEPA filtration, ... ionization modules also available, ...
... new Hummingbird has the ability to quickly and ... makes it a perfect candidate for inclusion in ... OCX interface supplied with all the Cartesian products ... Hummingbirds ability to copy plates in seconds ...
Biology Products: