Navigation Links
Texas A&M Researchers Examine How Viruses Destroy Bacteria
Date:11/18/2009

Viruses are well known for attacking humans and animals, but some viruses instead attack bacteria. Texas A&M University researchers are exploring how hungry viruses, armed with transformer-like weapons, attack bacteria, which may aid in the treatment of bacterial infections.

The Texas A&M researchers' work is published in the renowned journal Nature Structural & Molecular Biology.

The attackers are called phages, or bacteriophages, meaning eaters of bacteria.

The word bacteriophage is derived from the Greek "phagein," meaning eater of bacteria.

"The phages first attach to the bacteria and then inject their DNA," says Sun Qingan, coauthor of the article and a doctoral student at Texas A&M. "Then they reproduce inside the cell cytoplasm."

After more than 100 phage particles have been assembled, the next step is to be released from the bacterial host, so that the progeny virions can find other hosts and repeat the reproduction cycle, Sun adds.

Besides the cell membrane, the phages have another obstacle on their way out a hard shell called cell wall that protects the bacteria. Only by destroying the cell wall can the phages release their offspring.

But, don't worry. The phages have a secret weapon an enzyme that can destroy the wall from inside, thus called endolysin.

"One of the special examples, R21, remains inactive when it is first synthesized and attached to the membrane as demonstrated in our paper," Sun explains. "But when the enzyme leaves the membrane, it restructures just like a transformer and gains the power to destroy the cell wall."

The trigger controlling the transformation process is a segment of the enzyme call the SAR domain, according to the Texas A&M team.

"The SAR domain is like the commander it tells the enzyme when to begin restructuring and destroying the cell wall," he says. "This finding enables us to better understand the release process and provides us with a possible target when we want to control the destruction of bacteria cell walls or prohibit this action in some infectious diseases."

Some research has been conducted to explore the possibility of using phages to kill bacteria and thus treating bacterial infections.

Sun and colleagues' finding unveils one secret of the phages and may be useful in phage therapy and other applications.


'/>"/>

Contact: Sun Qingan
q-sun@neo.tamu.edu
979-862-7639
Texas A&M University
Source:Eurekalert

Related biology news :

1. Texas researchers and educators head for Antarctica
2. Ceres and Texas A&M to develop and market high-biomass sorghum for biofuels
3. Gulf of Mexico dead zone to be studied by University of Texas at Austin marine scientists
4. UT Southwestern scientist honored among best in Texas research
5. Rices West honored as one of Texas best researchers
6. Texas Hospital nations first to use large-scale cocoon strategy against whooping cough
7. Texas A&M testing oral contraceptives for animals
8. Texas A&M scientists say early Americans arrived earlier
9. Researchers confirm dead zone off Texas coast since 1985
10. Underwater microscope helps prevent shellfish poisoning along Gulf Coast of Texas
11. UTMB inventions win University of Texas System commercialization awards
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... Mar. 23, 2017 Research and Markets has ... Analysis & Trends - Industry Forecast to 2025" report to ... ... a CAGR of around 8.8% over the next decade to reach ... analyzes the market estimates and forecasts for all the given segments ...
(Date:3/20/2017)... , March 20, 2017 At this year,s ... -based biometrics manufacturer DERMALOG. The Chancellor came to the DERMALOG stand ... is this year,s CeBIT partner country. At the largest German biometrics ... in use: fingerprint, face and iris recognition as well as DERMALOG´s multi-biometrics ... ...
(Date:3/9/2017)... , Australia , March 9, ... study data at the prestigious World Lung Imaging Workshop ... Andreas Fouras , was invited to deliver the ... pulmonary medicine. This globally recognised event brings together leaders ... share the latest developments in lung imaging. ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... ... April 27, 2017 , ... Mitotech S.A, a Luxembourg ... Hereditary Optic Neuropathy (LHON) patients. LHON is a rare devastating genetic disease that leads ... eye drops in a group of 20 patients carrying 11778, 14484 and 3460 mutations ...
(Date:4/27/2017)... ... April 27, 2017 , ... During the course ... how testing for 1,25-Dihydroxyvitamin D can enhance clinical practice. Participants will learn the ... dihydroxyvitamin D. , Dr. Gregory Plotnikoff, senior consultant with Minnesota Personalized Medicine, will ...
(Date:4/27/2017)... USA (PRWEB) , ... April 27, 2017 , ... ... optics and photonics , joined other scientists, researchers, engineers, and industry professionals in ... to strengthen America's ability to compete in the world photonics industry. , This ...
(Date:4/27/2017)... , April 27, 2017  Kinexum, a distinguished ... products, today announces the appointment of Thomas C. ... Alexander ("Zan") Fleming, M.D., Kinexum founder, who becomes Executive ... advisor to Kinexum clients. Thomas Seoh ... on the Kinexum mission and lead the firm,s remarkable ...
Breaking Biology Technology: