Navigation Links
Tests show bright future for gadonanotubes in stem cell tracking
Date:11/12/2010

Gadonanotubes (GNTs) developed at Rice University are beginning to show positive results in a study funded by a federal stimulus grant through the National Institutes of Health (NIH) last year.

The study has determined GNTs are effective in helping doctors track stems cells through the body by making them 40 times better than standard contrast agents used in magnetic resonance imaging. Contrast agents help doctors spot signs of disease or damage in MR images.

Researchers at Rice and the Texas Heart Institute at St. Luke's Episcopal Hospital in Houston reported in the journal Biomaterials that mesenchymal stem cells drawn from pig bone marrow labeled with GNTs are easily spotted under MRI. The technique holds promise for tracking the progress of tagged cells as they travel through a patient's body.

Ultimately, the team hopes the magnetic properties of tagged stem cells will allow doctors to manipulate them in vivo and direct cells to specific locations -- in the heart, for instance -- where they can heal damaged tissue.

GNTs are carbon nanotubes that contain gadolinium, an element commonly used in designing contrast elements for use in MRI. Though toxic, gadolinium is chelated, or chemically bound, which makes it safer for injection into the body. But clinical agents like the gadolinium-based Magnevist cannot enter cells.

However, GNTs can. Invented in the lab of Rice chemistry professor Lon Wilson in 2005, the nanotubes sequester bundles of gadolinium ions, which enhance contrast in MRIs but cannot escape their carbon cages. This makes them biologically inert and safe for tagging cells from within.

The team found GNTs did not affect the stem cells' ability to differentiate into other types of cells or to self-renew, though work continues to characterize their ability to adhere to cell scaffolds under various conditions.


'/>"/>

Contact: David Ruth
druth@rice.edu
713-348-6327
Rice University
Source:Eurekalert

Page: 1

Related biology news :

1. Built-in timer for improving accuracy of cost saving paper-strip medical tests
2. PNNL and Air Force 59th to develop better tests for drug abuse and dependence
3. Initial trials on new ovarian cancer tests exhibit extremely high accuracy
4. AMP comments at FDA meeting on array-based tests
5. Plastic antibody works in first tests in living animals
6. Pitt researcher says simple polymer-based filter successfully cleans water, recovers oil in Gulf of Mexico tests
7. New technique enables drug tests via exhaled breath
8. Microfluidic integrated circuit could help enable home diagnostic tests
9. Papaya extract thwarts growth of cancer cells in lab tests
10. AMP releases statement on oversight of laboratory tests
11. Scientists take step toward simple and portable tuberculosis tests for developing world
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... April 14, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces ... the 2015 New York Design Awards under the category  ... York City Design Awards are part of a global ... 2,500 ratings from the marketplace, industry and judging panel. ...
(Date:4/8/2015)... N.C. , April 8, 2015  Infinisource, ... solutions and services, and Morpho, a leading supplier ... partnership to produce the market,s most advanced biometrically-enabled ... Infinisource,s iSolved NXG time clock is setting a ... and labor data for the small and mid-size ...
(Date:4/2/2015)... , April 2, 2015 ... touch fingerprint sensor FPC1025 from the distributor World Peace ... commence during Q2 2015 although the major part of ... sensors will be used by smartphone manufacturers in ... MSEK is included in the communicated revenue guidance of ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2
... technique that will help the scientific community to analyze -- ... critical role in regulating gene expression has been developed by ... biologist at Penn State University. The scientists developed a method ... fold within living cells, thus shedding new light on how ...
... a significant signaling network in a tiny organism that,s ... about how a remarkably fast-growing organism conducts its metabolic ... hardy microbe Synechococcus , which turns sunlight into ... Energy,s Pacific Northwest National Laboratory glimpsed key chemical events, ...
... In a paper published in Nature Genetics , ... Korea Genome Research Foundation, BGI, and other institutes presented ... findings on how whales successfully adapted to ocean environment. ... future studies of marine mammal diseases, conservation and evolution. ...
Cached Biology News:New tool developed for profiling critical regulatory structures of RNA molecules 2New tool developed for profiling critical regulatory structures of RNA molecules 3Scientists capture 'redox moments' in living cells 2Scientists capture 'redox moments' in living cells 3New genomic study provides a glimpse of how whales could adapt to ocean 2
(Date:4/23/2015)... SAN FRANCISCO, Calif. , April 23, 2015  Veracyte, ... has entered into a definitive agreement to sell approximately ... placement. Under the agreement, the investors will purchase an ... purchase price of $8.15 per share, the closing stock ... led by new and existing investors, including Broadfin Capital, ...
(Date:4/23/2015)... April 23, 2015  Metanome, Inc., an industry ... company has changed its name to Diversigen, Inc.  ... as the single commercial source for the myriad ... on the diverse opportunities of the microbiome.  From ... accepts – including those that are difficult to ...
(Date:4/23/2015)... CA (PRWEB) April 23, 2015 Delpor, ... today announced that the United States Patent and Trademark ... Company’s NANOPOR™ technology. US Pat. No. ... Delpor’s microfabricated drug delivery device for the ... proprietary NANOPOR™ technology for the sustained (zero-order) release of ...
(Date:4/22/2015)... SEATTLE , April 22, 2015   ... startup, today announced $1.6M in Series A financing ... investor. The funding helps accelerate consumer and employer ... scores covering surgeries at over 4,800 U.S. hospitals. ... surgery, you are probably very concerned about choosing ...
Breaking Biology Technology:Veracyte, Inc. Announces $40 Million Private Placement 2Veracyte, Inc. Announces $40 Million Private Placement 3Veracyte, Inc. Announces $40 Million Private Placement 4Metanome Announces Corporate Name Change to Diversigen 2Delpor, Inc. Announces the Issuance of 2 New US Patents Based on its Nanopore Technology which Enables the Sustained Release of Drugs from a Small Implant Device 2Delpor, Inc. Announces the Issuance of 2 New US Patents Based on its Nanopore Technology which Enables the Sustained Release of Drugs from a Small Implant Device 3MPIRICA Health Inc. Secures $1.6M to Promote FICO-Like Quality Scores for Surgeries 2
... if your water source has hexavalent chromium is to ... water quality report, said NJIT Professor Taha Marhaba, a ... be able to provide such a report upon request. ... also be available. "In general, hexavalent chromium can ...
... from explosives to tainted milk, materials for use in ... a University of Houston (UH) chemist and his team. ... "There are many dangerous substances, pollutants and infectious ... a highly cited materials scientist at UH. "Our work ...
... nanoengineering, a team of scientists at Kyoto University and ... programable molecular transport system, the workings of which can ... the latest issue of Nature Nanotechnology , open ... methods and molecular manufacturing systems. Resembling a monorail ...
Cached Biology Technology:Removal of hexavalent chromium from your drinking water 2Removal of hexavalent chromium from your drinking water 3Sensors to detect explosives, monitor food being developed at UH 2Sensors to detect explosives, monitor food being developed at UH 3
...
... Nonanoyl-N-methylglucamide White solid. Water-soluble ... readily removed by dialysis. Useful reagent ... by HPLC. Absorbance (10%, H ... O. CMC 19 - 25 mM. ...
Anti Autotaxin /ENPP2 , - (Rabbit)...
... Tecans MiniPrep series of robotic workstations ... The MiniPrep is the ideal automation ... automation of routine laboratory procedures, improving throughput, ... based Gemini for MiniPrep software allows you ...
Biology Products: