Navigation Links
Tests show bright future for gadonanotubes in stem cell tracking
Date:11/12/2010

Gadonanotubes (GNTs) developed at Rice University are beginning to show positive results in a study funded by a federal stimulus grant through the National Institutes of Health (NIH) last year.

The study has determined GNTs are effective in helping doctors track stems cells through the body by making them 40 times better than standard contrast agents used in magnetic resonance imaging. Contrast agents help doctors spot signs of disease or damage in MR images.

Researchers at Rice and the Texas Heart Institute at St. Luke's Episcopal Hospital in Houston reported in the journal Biomaterials that mesenchymal stem cells drawn from pig bone marrow labeled with GNTs are easily spotted under MRI. The technique holds promise for tracking the progress of tagged cells as they travel through a patient's body.

Ultimately, the team hopes the magnetic properties of tagged stem cells will allow doctors to manipulate them in vivo and direct cells to specific locations -- in the heart, for instance -- where they can heal damaged tissue.

GNTs are carbon nanotubes that contain gadolinium, an element commonly used in designing contrast elements for use in MRI. Though toxic, gadolinium is chelated, or chemically bound, which makes it safer for injection into the body. But clinical agents like the gadolinium-based Magnevist cannot enter cells.

However, GNTs can. Invented in the lab of Rice chemistry professor Lon Wilson in 2005, the nanotubes sequester bundles of gadolinium ions, which enhance contrast in MRIs but cannot escape their carbon cages. This makes them biologically inert and safe for tagging cells from within.

The team found GNTs did not affect the stem cells' ability to differentiate into other types of cells or to self-renew, though work continues to characterize their ability to adhere to cell scaffolds under various conditions.


'/>"/>

Contact: David Ruth
druth@rice.edu
713-348-6327
Rice University
Source:Eurekalert

Page: 1

Related biology news :

1. Built-in timer for improving accuracy of cost saving paper-strip medical tests
2. PNNL and Air Force 59th to develop better tests for drug abuse and dependence
3. Initial trials on new ovarian cancer tests exhibit extremely high accuracy
4. AMP comments at FDA meeting on array-based tests
5. Plastic antibody works in first tests in living animals
6. Pitt researcher says simple polymer-based filter successfully cleans water, recovers oil in Gulf of Mexico tests
7. New technique enables drug tests via exhaled breath
8. Microfluidic integrated circuit could help enable home diagnostic tests
9. Papaya extract thwarts growth of cancer cells in lab tests
10. AMP releases statement on oversight of laboratory tests
11. Scientists take step toward simple and portable tuberculosis tests for developing world
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... , March 30, 2017  On April 6-7, 2017, ... the Genome hackathon at Microsoft,s headquarters in ... competition will focus on developing health and wellness apps ... Hack the Genome is the first hackathon ... The world,s largest companies in the genomics, tech and ...
(Date:3/29/2017)... , March 29, 2017  higi, the health ... in North America , today announced ... and the acquisition of EveryMove. The new investment and ... set of tools to transform population health activities through ... lifestyle data. higi collects and secures data ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed Anwar ... prestigious international IAIR Award for the most innovative high security ePassport and ... ... Maldives Immigration Controller General, Mr. Mohamed ... the right) have received the IAIR award for the "Most innovative high ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... , ... May 23, 2017 ... ... an unlimited source of human cardiovascular cells for research and the development ... makes it possible to generate large numbers of cardiomyocytes (hPSC-CMs). Due to ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... ... for advanced technology applications, has announced a facility expansion to accommodate its rapid ... square feet of new workspace and renovation of the existing areas. The expansion ...
(Date:5/22/2017)... Boston, MA (PRWEB) , ... May 22, 2017 , ... ... evidence, has expanded to the East Coast. It has opened an office in downtown ... innovative therapies are finding it increasingly more important to generate evidence on the value ...
(Date:5/19/2017)... (PRWEB) , ... May 19, 2017 , ... In response ... treating gait disorders, Biodex Medical Systems, Inc. announces the release of their Gait Trainer ... has been joined with a biomedical system to aid in rehabilitating individuals with cerebral ...
Breaking Biology Technology: