Navigation Links
Tests show bright future for gadonanotubes in stem cell tracking
Date:11/12/2010

Gadonanotubes (GNTs) developed at Rice University are beginning to show positive results in a study funded by a federal stimulus grant through the National Institutes of Health (NIH) last year.

The study has determined GNTs are effective in helping doctors track stems cells through the body by making them 40 times better than standard contrast agents used in magnetic resonance imaging. Contrast agents help doctors spot signs of disease or damage in MR images.

Researchers at Rice and the Texas Heart Institute at St. Luke's Episcopal Hospital in Houston reported in the journal Biomaterials that mesenchymal stem cells drawn from pig bone marrow labeled with GNTs are easily spotted under MRI. The technique holds promise for tracking the progress of tagged cells as they travel through a patient's body.

Ultimately, the team hopes the magnetic properties of tagged stem cells will allow doctors to manipulate them in vivo and direct cells to specific locations -- in the heart, for instance -- where they can heal damaged tissue.

GNTs are carbon nanotubes that contain gadolinium, an element commonly used in designing contrast elements for use in MRI. Though toxic, gadolinium is chelated, or chemically bound, which makes it safer for injection into the body. But clinical agents like the gadolinium-based Magnevist cannot enter cells.

However, GNTs can. Invented in the lab of Rice chemistry professor Lon Wilson in 2005, the nanotubes sequester bundles of gadolinium ions, which enhance contrast in MRIs but cannot escape their carbon cages. This makes them biologically inert and safe for tagging cells from within.

The team found GNTs did not affect the stem cells' ability to differentiate into other types of cells or to self-renew, though work continues to characterize their ability to adhere to cell scaffolds under various conditions.


'/>"/>

Contact: David Ruth
druth@rice.edu
713-348-6327
Rice University
Source:Eurekalert

Page: 1

Related biology news :

1. Built-in timer for improving accuracy of cost saving paper-strip medical tests
2. PNNL and Air Force 59th to develop better tests for drug abuse and dependence
3. Initial trials on new ovarian cancer tests exhibit extremely high accuracy
4. AMP comments at FDA meeting on array-based tests
5. Plastic antibody works in first tests in living animals
6. Pitt researcher says simple polymer-based filter successfully cleans water, recovers oil in Gulf of Mexico tests
7. New technique enables drug tests via exhaled breath
8. Microfluidic integrated circuit could help enable home diagnostic tests
9. Papaya extract thwarts growth of cancer cells in lab tests
10. AMP releases statement on oversight of laboratory tests
11. Scientists take step toward simple and portable tuberculosis tests for developing world
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... and ITHACA, N.Y. , June ... Cornell University, a leader in dairy research, today announced ... designed to help reduce the chances that the global ... onset of this dairy project, Cornell University has become ... Sequencing the Food Supply Chain, a food safety initiative ...
(Date:5/16/2017)...  Veratad Technologies, LLC ( www.veratad.com ), an innovative ... verification solutions, announced today they will participate as a ... thru May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions ... evolving digital world, defining identity is critical to nearly ...
(Date:4/24/2017)... , April 24, 2017 Janice ... partner with  Identity Strategy Partners, LLP (IdSP) , ... or without President Trump,s March 6, 2017 ... Entry , refugee vetting can be instilled with greater ... (Right now, all refugee applications are suspended by ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... ... Disappearing forests and increased emissions are the main causes of the evolving air ... living in larger cities are affected by air pollution related diseases. , That is ... globally - decided to take action. , “I knew I had to take action ...
(Date:10/10/2017)... ... , ... San Diego-based team building and cooking events company, Lajollacooks4u, has unveiled ... bold new look is part of a transformation to increase awareness, appeal to new ... , It will also expand its service offering from its signature gourmet cooking classes ...
(Date:10/10/2017)... ... ... Dr. Bob Harman, founder and CEO of VetStem Biopharma, Inc. ... event entitled “Stem Cells and Their Regenerative Powers,” was held on August 31st, ... was joined by two human doctors: Peter B. Hanson, M.D., Chief of Orthopedic Surgery, ...
(Date:10/10/2017)... ... 10, 2017 , ... USDM Life Sciences , the ... sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer Jaye ... GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to achieving ...
Breaking Biology Technology: