Navigation Links
Test to improve peanut allergy diagnosis

Researchers from Murdoch Childrens Research Institute and the University of Melbourne have identified a new way to accurately test for peanut allergy.

It is hoped the test would be more cost effective and convenient than standard approaches and minimise over-diagnosis of peanut allergy in the community.

Currently, an oral food challenge is the standard for diagnosing peanut allergy, and while an oral food challenge is definitive in diagnosing patients, it is time-consuming, costly and patients risk severe reactions such as anaphylaxis.

The new test researchers have identified uses part of the peanut protein called 'Arah2' and involves a two-step screening process. Researchers found they could perform a blood test, followed by the Arah2 test, which was more accurate and highly predictive than using one of the tests alone. They found the two step testing process reduced the need for oral food challenges by four-fold.

Co-lead researcher, Thanh Dang, a University of Melbourne PhD student based at the Murdoch Childrens Research Institute, said the new test has many benefits.

"By reducing the number of oral food challenges, this helps prevent many peanut allergics undertaking the unnecessary risks involved."

A/Professor Katie Allen said the new test could reduce the burden on clinicians and the health care system.

"Due to the rapid increase in rates of sensitisation to foods, allergy services are overwhelmed, and food challenge tests might be difficult to access. This method would help alleviate the current strain and demand on clinical allergy services, with the allergy patient waiting times in excess of 18 months in many centres in Australia," she said.

Researchers say the test would also help minimise over-diagnosis, and would reduce the number of patients requiring referral to specialist services for confirmation of a food allergy, by using oral food challenges.

Patients would simply need to visit a GP rather than require a referral to a specialist allergy clinic.

"Due to the long wait times for specialist's clinics, many clinicians are faced with the difficult task of having to assess the presence of food allergy based solely on a positive skin prick test or other available tests and must err on the side of caution and accept a diagnosis of 'possible' food allergy in these situations," Dr Allen said

"This approach can lead to over diagnosis of peanut allergy in the community and a potentially unnecessary burden on the health care system," she said.

Diagnosis of peanut allergy is relatively straightforward when there is an obvious history of clinical reaction to peanut ingestion. However, diagnosis can be more complicated in cases in which the clinical history is not clear or in children who have not yet been exposed to a food.

Researchers say the 'Arah2' twostep process can be used in children with high risk of food allergy, such as those with eczema and other food allergies and for those who haven't eaten peanuts but have a strong family history of food allergy.

Contact: Rebecca Scott
University of Melbourne

Related biology news :

1. Improved Authentication and Confidentiality Protection. ICAP Patent Brokerage Announces for Auction Important Patents in Data Encryption and Document Security
2. UNH researchers find African farmers need better climate change data to improve farming practices
3. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
4. New treatment using inhaled interferon may improve lung function in pulmonary fibrosis
5. MU scientists study how to improve pesticide efficiency
6. Engineers improve allocation of limited health care resources in resource-poor nations
7. Organic farming improves pollination success in strawberries
8. Cardiac MRI shown to improve diagnosis in patients with life-threatening arrhythmias
9. New guidelines developed for improved DVT diagnosis
10. New web tool to improve accuracy of global land cover maps
11. Critical element that improves vascular function in postmenopausal women found
Post Your Comments:
(Date:11/12/2015)... , Nov. 12, 2015  A golden retriever that ... muscular dystrophy (DMD) has provided a new lead for ... Hospital, the Broad Institute of MIT and Harvard and ... . Cell, pinpoints a ... "escape" the disease,s effects. The Boston Children,s lab of ...
(Date:11/10/2015)... , Nov. 10, 2015 ... behavioral biometrics that helps to identify and verify ... Signature is considered as the secure and accurate ... identification of a particular individual because each individual,s ... accurate results especially when dynamic signature of an ...
(Date:10/29/2015)... Minn. , Oct. 29, 2015   MedNet ... supports the entire spectrum of clinical research, is pleased ... Minnesota High Tech Association (MHTA) as one of only ... in the "Software – Small and Growing" category. The Tekne ... individuals who have shown superior technology innovation and leadership. ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... 25, 2015 Studies reveal the ... plaque and pave the way for more effective treatment for ...     --> --> ... health problems in cats, yet relatively little was understood about ... studies have been conducted by researchers from the WALTHAM Centre ...
(Date:11/25/2015)... /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS; TSX: AEZ) ... remain fundamentally strong and highlights the following developments: ... DSMB recommendation to continue the ZoptEC Phase 3 ... final interim efficacy and safety data , ... with heavily pretreated castration- and Taxane-resistant prostate cancer ...
(Date:11/25/2015)... 2015 The Global Genomics ... professional and in-depth study on the current state ... ) , The report ... definitions, classifications, applications and industry chain structure. The ... markets including development trends, competitive landscape analysis, and ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... The United ... recipient of the 2016 USGA Green Section Award. Presented annually since 1961, the USGA ... his or her work with turfgrass. , Clarke, of Iselin, N.J., is ...
Breaking Biology Technology: