Navigation Links
Test detects molecular marker of aging in humans
Date:6/16/2009

CHAPEL HILL, N.C. In 2004, researchers at the University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center announced a crucial discovery in the understanding of cellular aging. They found that as cells and tissues age, the expression of a key protein, called p16INK4a, dramatically increases in most mammalian organs. Because p16INK4a is a tumor suppressor protein, cancer researchers are interested in its role in cellular aging and cancer prevention.

Now the team has proven that the same biomarker is present in human blood and is strongly correlated both with chronological age and with certain behaviors such as tobacco use and physical inactivity, which are known to accelerate the aging process.

In a paper published online ahead of print in the journal Aging Cell, the researchers reported that they have solved technical hurdles to develop a simple blood test to detect p16INK4a expression, which is present in cells called T-lymphocytes, also known as T-cells.

"This is a major step toward a practical tool to clinically determine a person's actual molecular, as opposed to just their chronological age," said UNC Lineberger member Norman Sharpless, M.D., the senior author of the study and associate professor of medicine and genetics at UNC's School of Medicine.

They validated the test by obtaining blood from two groups of healthy human volunteers, totaling 170 subjects, who also filled out a questionnaire about current and past health status and health behaviors.

They found that expression of the biomarker was strongly correlated with the donor's chronological age and, in fact, increased exponentially with age. In addition, increased levels were independently associated with tobacco use and physical inactivity as well as with biomarkers of human frailty.

Sharpless said that the researchers were surprised by some of their findings, "We found a very weak correlation between the biom
'/>"/>

Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. New field-deployable biosensor detects avian influenza virus in minutes instead of days
2. Insect gut detects unhealthy meal
3. Portable device quickly detects early Alzheimers
4. Nano-tetherball biosensor precisely detects glucose
5. Scattered light rapidly detects tumor response to chemotherapy
6. NASA satellite detects red glow to map global ocean plant health
7. New device detects heart disease using less than one drop of blood
8. New molecular regulators of hyperthyroidism and goiter
9. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
10. UC health news: molecular pathway may predict chemotherapy effectiveness
11. New molecular clock from LLNL and CDC indicates smallpox evolved earlier than believed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... , January 28, 2015 New ... Size And Segment Forecasts To 2020 has Been Added ... camera market is expected to reach USD 5.10 billion ... View Research, Inc. IR cameras help identify the site ... expected to witness surging demand in medical imaging applications. ...
(Date:2/5/2015)... Jan. 30, 2015  It is gratifying to see ... potential for genomic science as a means to better ... and treatment.  I was honored to participate in today,s ... medicine program. Since the 1980s my ... genomics—from the first sequenced genome of a free living ...
(Date:1/22/2015)... , Jan. 9, 2015 Valid S.A. ("Company") (BM&FBOVESPA: ... market in general the State of Washington,s ... for a new enrollment and central issuance system for driver,s ... The project planning and development will start in ...
Breaking Biology News(10 mins):IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 2IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 3J. Craig Venter, Ph.D., Co-Founder and CEO, Human Longevity, Inc. (HLI) Participates in White House Precision Medicine Event 2Valid USA Signs Contract For Washington Driver's License Issuance 2
... UT Southwestern Medical Center have uncovered a key step in ... study. They found that a tiny fragment of ... cells to mature into red blood cells. The researchers also ... Such interventions, if fruitful in humans, might be useful against ...
... bloodhounds, but finding bodies buried by someone who wanted ... new technique developed by scientists at the National Institute ... changes in a decomposing cadaver. Typically, cadaver-sniffing dogs ... gravesites. But these methods are not always useful in ...
... PROVIDENCE, R.I. [Brown University] Researchers from Brown University and ... changes to DNA in breast cancers are related to environmental ... severity of the disease. The study is published in ... that epigenetic profiles of tumors had a direct association with ...
Cached Biology News:UT Southwestern researchers find key step in body's ability to make red blood cells 2Body of evidence: New fast, reliable method to detect gravesoil 2Study finds diet and alcohol alter epigenetics of breast cancer 2
(Date:2/26/2015)... On behalf of biotech client ... Wilentz, Goldman & Spitzer, P.A. (Wilentz) secured a ... Genewiz Inc. in excess of $10 million. The jury ... secrets, and that it improperly hired one or more ... denying motions for judgment notwithstanding the verdict, a new ...
(Date:2/26/2015)... (PRWEB) February 26, 2015 The ... -12, at the Ernest N. Morial Convention Center ... (count as of February 19, 2015) displaying products ... industrial, academic, and government labs. The Exposition will ... but not limited to, analytical chemistry; drug discovery; ...
(Date:2/26/2015)... 2015 According to a new market ... For Transgenic Crops (Corn, Soybean, Cotton and Others), Synthetic ... Share, Growth, Trends and Forecast, 2013 – 2019,”the global ... in 2012 and is expected to reach USD 28,694.1 ... from 2013 to 2019. , Demand for food ...
(Date:2/26/2015)... 2015 Tauriga Sciences, Inc. (OTCQB: TAUG) ("Tauriga" or ... in the natural wellness sector and in developing a ... products will be featured at the SEC Compliance sponsor ... Annual Growth Stock Conference on March 8-11 th ... Carlton Drive, Dana Point , California.  ...
Breaking Biology Technology:Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 2Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 3Pittcon 2015 Announces Exposition Highlights 2Global Agricultural Biotechnology Market is Expected to Reach USD 28,694.1 Million in 2019 : Transparency Market Research 2Global Agricultural Biotechnology Market is Expected to Reach USD 28,694.1 Million in 2019 : Transparency Market Research 3SEC Compliance Featuring Products From Tauriga Sciences, Inc. at ROTH Capital Conference 2SEC Compliance Featuring Products From Tauriga Sciences, Inc. at ROTH Capital Conference 3SEC Compliance Featuring Products From Tauriga Sciences, Inc. at ROTH Capital Conference 4
... Beckman Coulter,Inc. (NYSE: BEC ), a leading ... and innovate complex biomedical testing,announced today that Robert ... at the Lazard Capital Markets Fourth Annual,Healthcare Conference ... (ET). (Logo: http://www.newscom.com/cgi-bin/prnh/20031202/BECLOGO ) The ...
... Mass., Nov. 19 Advanced Instruments, Inc., ... acquired 100% of the,shares of Mart Microbiology ... the,transaction were not disclosed. Mart Microbiology ... These systems create custom environments for anaerobic,bacteria ...
... MALVERN, Pa., Nov. 19 Siemens Medical ... and,healthcare systems innovate their clinical and financial ... At the 93rd Scientific Assembly and Annual ... (RSNA) from Nov. 25 to 30 at,McCormick ...
Cached Biology Technology:Beckman Coulter to Present at the Lazard Capital Markets Fourth Annual Healthcare Conference 2Advanced Instruments Acquires Mart Microbiology B.V. 2Siemens Customers Innovate Their Clinical and Financial Workflows with Help from Soarian 2Siemens Customers Innovate Their Clinical and Financial Workflows with Help from Soarian 3
... Vesicular Monoamine Transporter 2 (VMAT2). An antibody ... a major band at ~55 kDa in ... and not in wild type cells (2). ... molecular weight, were also detected and remain ...
... The INK4a-ARF locus encodes two unrelated ... suppression. p14^ARF^ arrests the cell cycle in ... and promotes the rapid degradation of mdm2 ... stabilization and accumulation. This interaction is ...
... Anti-Matrix Metalloproteinase-2, Hinge Region By immunoblotting ... native protein. It reacts with free MMP-2 ... antibody buffered aqueous glycerol solution ... pH 7.4, containing 50% glycerol and 15 ...
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. Mfr ...
Biology Products: