CHAPEL HILL, N.C. In 2004, researchers at the University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center announced a crucial discovery in the understanding of cellular aging. They found that as cells and tissues age, the expression of a key protein, called p16INK4a, dramatically increases in most mammalian organs. Because p16INK4a is a tumor suppressor protein, cancer researchers are interested in its role in cellular aging and cancer prevention.
Now the team has proven that the same biomarker is present in human blood and is strongly correlated both with chronological age and with certain behaviors such as tobacco use and physical inactivity, which are known to accelerate the aging process.
In a paper published online ahead of print in the journal Aging Cell, the researchers reported that they have solved technical hurdles to develop a simple blood test to detect p16INK4a expression, which is present in cells called T-lymphocytes, also known as T-cells.
"This is a major step toward a practical tool to clinically determine a person's actual molecular, as opposed to just their chronological age," said UNC Lineberger member Norman Sharpless, M.D., the senior author of the study and associate professor of medicine and genetics at UNC's School of Medicine.
They validated the test by obtaining blood from two groups of healthy human volunteers, totaling 170 subjects, who also filled out a questionnaire about current and past health status and health behaviors.
They found that expression of the biomarker was strongly correlated with the donor's chronological age and, in fact, increased exponentially with age. In addition, increased levels were independently associated with tobacco use and physical inactivity as well as with biomarkers of human frailty.
Sharpless said that the researchers were surprised by some of their findings, "We found a very weak correlation between the biom
'/>"/>
| Contact: Ellen de Graffenreid edegraff@med.unc.edu 919-962-3405 University of North Carolina School of Medicine Source:Eurekalert |
Related biology news :
1. New field-deployable biosensor detects avian influenza virus in minutes instead of days
2. Insect gut detects unhealthy meal
3. Portable device quickly detects early Alzheimers
4. Nano-tetherball biosensor precisely detects glucose
5. Scattered light rapidly detects tumor response to chemotherapy
6. NASA satellite detects red glow to map global ocean plant health
7. New device detects heart disease using less than one drop of blood
8. New molecular regulators of hyperthyroidism and goiter
9. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
10. UC health news: molecular pathway may predict chemotherapy effectiveness
11. New molecular clock from LLNL and CDC indicates smallpox evolved earlier than believed
| Copyright © 2003-2012 Bio-Medicine. All rights reserved. ABOUT | CONTACT US | DISCLAIMER | PRIVACY POLICY | TERMS AND CONDITIONS |  |