Navigation Links
Tentacles of venom: New study reveals all octopuses are venomous
Date:4/15/2009

Once thought to be only the realm of the blue-ringed octopus, researchers have now shown that all octopuses and cuttlefish, and some squid are venomous. The work indicates that they all share a common, ancient venomous ancestor and highlights new avenues for drug discovery.

Conducted by scientists from the University of Melbourne, University of Brussels and Museum Victoria, the study was published in the Journal of Molecular Evolution.

Dr Bryan Fry from the Department of Biochemistry at the Bio21 Institute, University of Melbourne said that while the blue-ringed octopus species remain the only group that aredangerous to humans, the other species have been quietly using their venom for predation, such as paralysing a clam into opening its shell.

"Venoms are toxic proteins with specialised functions such as paralysing the nervous system" he said.

"We hope that by understanding the structure and mode of action of venom proteins we can benefit drug design for a range of conditions such as pain management, allergies and cancer."

While many creatures have been examined as a basis for drug development, cephalopods (octopuses, cuttlefish and squid) remain an untapped resource and their venom may represent a unique class of compounds.

Dr Fry obtained tissue samples from cephalopods ranging from Hong Kong, the Coral Sea, the Great Barrier Reef and Antarctica.

The team then analysed the genes for venom production from the different species and found that a venomous ancestor produced one set of venom proteins, but over time additional proteins were added to the chemical arsenal.

The origin of these genes also sheds light on the fundamentals of evolution, presenting a prime example of convergent evolution where species independently develop similar traits.

The team will now work on understanding why very different types of venomous animals seem to consistently settle on the similar venom protein composition, and which physical or chemical properties make them predisposed to be useful as toxin.

"Not only will this allow us to understand how these animals have assembled their arsenals, but it will also allow us to better exploit them in the development of new drugs from venoms," said Dr Fry.

"It does not seem a coincidence that some of the same protein types have been recruited for use as toxins across the animal kingdom."


'/>"/>

Contact: Nerissa Hannink
nhannink@unimelb.edu.au
61-383-448-151
University of Melbourne
Source:Eurekalert

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2016)... , March 29, 2016 ... "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased to ... ink used in a variety of writing instruments, ensuring ... of originally created collectibles from athletes on LegacyXChange will ... analysis of the DNA. Bill Bollander ...
(Date:3/22/2016)... 2016 According to ... for Consumer Industry by Type (Image, Motion, Pressure, ... & IT, Entertainment, Home Appliances, & Wearable ... 2022", published by MarketsandMarkets, the market for ... USD 26.76 Billion by 2022, at a ...
(Date:3/21/2016)... Unique technology combines v ... security   Xura, Inc. ... digital communications services, today announced it is working alongside ... customers, particularly those in the Financial Services Sector, the ... within a mobile app, alongside, and in combination with, ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle ... people with peritoneal or pleural mesothelioma. Their findings are the subject of a new ... , Diagnostic biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma ...
(Date:6/23/2016)... Md. , June 23, 2016 A person ... from the crime scene to track the criminal down. ... the U.S. Food and Drug Administration (FDA) uses DNA evidence ... Sound far-fetched? It,s not. The FDA ... sequencing to support investigations of foodborne illnesses. Put as simply ...
(Date:6/23/2016)... June 23, 2016   EpiBiome , a precision ... million in debt financing from Silicon Valley Bank (SVB). ... and to advance its drug development efforts, as well ... "SVB has been an incredible strategic partner ... a traditional bank would provide," said Dr. Aeron ...
(Date:6/23/2016)... 23, 2016  Blueprint Bio, a company dedicated to ... medical community, has closed its Series A funding round, ... "We have received a commitment from Forentis ... need to meet our current goals," stated Matthew ... runway to complete validation on the current projects in ...
Breaking Biology Technology: