Navigation Links
Tension triggers muscle building
Date:3/14/2014

In order to move the body, skeletal muscles are pulling on the skeleton. For efficient muscle and skeletal movements it is essential that the muscle contracts only along a defined axis, for instance for the leg movement along the thigh. Such a directed contraction is achieved by the myofibrils that span through the entire length of the muscle. At both ends, the myofibrils are anchored to the tendon cells, which themselves are linked to the skeleton. "Thereby, the entire force is transduced from the muscle to the skeleton," Frank Schnorrer describes. How can the regular architecture of a many hundred sarcomeres long myofibril be built along a defined axis during muscle development?

PhD student Manuela Weitkunat and PostDoc Aynur Kaya-opur were investigating this question in the fruit fly Drosophila melanogaster. They discovered that shortly after the Drosophila flight muscles contact their tendons, mechanical tension is established. This tension buildup occurs before sarcomeres are formed and reaches through the entire muscle-tendon-skeleton system. This tension axis equips the muscle with positional information along which the sarcomeres must form.

Absence of tension results in chaos

By using genetic mutations in the fly, the scientists of the Muscle Dynamics group have been able to block the attachment of flight muscles to tendons and thus eliminate tension formation in the system. As a consequence, muscles could not build long regular myofibrils anymore but instead distribute the sarcomeric protein complexes chaotically. In order to directly test the influence of mechanical tension, the scientists used a laser to cut the tendons off the muscle. This strategy of tension release also led to a major defect in sarcomere and myofibril formation. "Based on these results, we are suggesting a new model of myofibril formation, which proposes tension dependent self-assembly of the sarcomeric components," explains Frank Schnorrer. "When a certain tension threshold is reached, myofibril formation is triggered. If tension is compromised, the sarcomeric components have no spatial information and assemble chaotically."

As human muscles also contain myofibrils that are built by periodically arrayed sarcomeres, it is likely that a similar tension-based assembly model may also apply during human muscle development, so the scientists think.


'/>"/>

Contact: Anja Konschak
konschak@biochem.mpg.de
49-898-578-2824
Max Planck Institute of Biochemistry
Source:Eurekalert

Related biology news :

1. Second-generation drug used for hypertension aids heart function independent of blood pressure
2. OHSU study shows that a molecule critical to nerve cells increases drammatically during hypertension
3. Sodium transporter appears likely target for treating salt-sensitive hypertension
4. A check on tension
5. Study uncovers mechanism for how grapes reduce heart failure associated with hypertension
6. Hypertension researcher encourages colleagues to expand their focus
7. How does Rho-associated protein kinase modulate neurite extension?
8. A single stem cell mutation triggers fibroid tumors
9. Finding triggers of birth defects in an embryo heart
10. Discovery shows fat triggers rheumatoid arthritis
11. Tissue loss triggers regeneration in planarian flatworms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/10/2019)... ... 2019 , ... When Dr. James L. Sherley, M.D., Ph.D., founder and director ... chapter to the new book Perinatal Stem Cells: Research and Therapy, he knew immediately ... debilitating secret of stem cell medicine. For more than a half-century, stem cell ...
(Date:1/8/2019)... HOUSTON (PRWEB) , ... January 07, 2019 , ... ... disposal and compliance solutions, is proud to welcome Thomas Kennedy as head of ... Jeffery Miglicco, CEO for PureWay. , Mr. Kennedy has previously worked for Johnson ...
(Date:1/7/2019)... ... January 07, 2019 , ... Franz Inc. , ... technology for Knowledge Graphs solutions, announced that it was recognized by Database ... DBTA’s data and information management recognition list includes newer approaches leveraging artificial intelligence, ...
Breaking Biology News(10 mins):
(Date:12/18/2018)... , ... December 18, 2018 , ... ... process optimization firm for the life sciences industry, unveiled a completely redesigned website ... creating a more user-friendly browsing experience for their valued clients and business partners. ...
(Date:12/13/2018)... ... December 12, 2018 , ... Helping conclude Healthy Aging ... sleek and slim hearing aid within its Vision and Hearing campaign that sets out ... , Studies show that despite continued efforts to destigmatize hearing aids over the years, ...
(Date:12/5/2018)... ... 05, 2018 , ... STRmix™ – sophisticated forensic software capable of resolving mixed ... to convict a Wyoming man of third-degree sexual assault, a felony punishable by imprisonment ... for DNA on the couch cushions on which the sexual assault was alleged to ...
(Date:11/26/2018)... ... November 26, 2018 , ... USARAD Holdings ... and Omphalos Venture Partners (Virtual Radiologic founders) among other healthcare investors exhibits at ... at McCormick Place in Chicago. The company is proud to announce a 10 ...
Breaking Biology Technology: