Navigation Links
Ten years on, Wellcome Trust launches study of 10,000 human genomes in UK
Date:6/24/2010

originally from Avon in southwest UK, followed from birth in 1991/2. The data for each group includes extensive description of their health and their development.

Studying this large group will help researchers build a near-complete catalogue of genetic variation in these 4,000 people. The depth of information recorded from them will provide a real opportunity to tie genetic variants to individual differences in health-related measurements. This should help identify the few thousand genetic variants amongst the 3 million each of us carries that are important in disease.

The information gathered from these 4,000 will be strengthened by the second component of 6,000 people, recruited by clinicians, who have a severe effect thought to have a genetic cause. These people have one of several conditions, including severe obesity, autism, schizophrenia and congenital heart disease. The gene-containing regions of their genomes known as 'exomes' which are likely to include the genetic variants important in their condition, will be analysed using new methods based in part on cutting-edge techniques developed at the Wellcome Trust Sanger Institute.

"We are fortunate in the UK to have such excellent collections of clinical samples provided by volunteers to help research and to help others," says Professor Tim Spector, who leads the TwinsUK study at King's College London. "10,000 volunteers have contributed to this, the largest genome sequencing project so far undertaken. It's a stunning commentary on the generosity of participants in UK studies."

The researchers point out that the results will have most immediate impact in genetics, contributing to an ongoing transformation of our understanding of human genetic variation. In some cases this may have direct clinical relevance. But more often it will lead to advance in medical science in understanding disease biology, which should, in time, reach through to medical applications.

'/>"/>
Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. First orchid fossil puts showy blooms at some 80 million years old
2. ESA celebrates 100 years of insect science journals
3. Researchers detect hint of oxygen 50 to 100 million years earlier than first believed
4. The benefits of 80 million years without sex
5. Researchers find origin of breathable atmosphere half a billion years ago
6. Fossil record reveals elusive jellyfish more than 500 million years old
7. Rodent fossils allows to determine climate of the Iberian Peninsula 6 million years ago
8. Atomic bomb survivor, scientists mark 60 years of long-term radiation study
9. Molecular Biology of the Cell celebrates 25 years of publication
10. 4 health behaviors can add 14 extra years of life
11. After more than 100 years apart, webworms devastate New Zealand parsnips
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... conducted by the Ocean Health Index rates the ... overall health. In addition, for the first time, ... ocean regions beyond national jurisdiction (high-seas areas) ... safeguarding biodiversity and providing sustainable food sources. , ... a partnership led by scientists from UC Santa ...
(Date:9/30/2014)... team of environmental scientists and engineers, led by ... a three-year, $5.25 million grant from the U.S. ... Research to make a direct positive impact on ... and disposal of radioactive contaminants. , "Understanding the ... dealing with environmental aspects of nuclear technologies is ...
(Date:9/30/2014)... and farm runoff in Hawaii is causing tumors in ... The study, published Tuesday in the peer-reviewed open-access journal ... ends up in algae that the turtles eat, promoting ... and internal organs. , Scientists at Duke University, the ... Administration (NOAA) conducted the study to better understand the ...
Breaking Biology News(10 mins):Rating the planet's oceans 2Rating the planet's oceans 3Researchers get $5.25 million to advance nuclear technologies in South Carolina 2Pollution linked to lethal sea turtle tumors 2Pollution linked to lethal sea turtle tumors 3
... Keith and his team are working to efficiently capture the ... technology. In research conducted at the U of C, ... to reduce carbon dioxide (CO2) the main greenhouse gas ... simple machine that can capture the trace amount of CO2 ...
... The Fraser fir is gaining popularity among American ... favor Fraser fir for its conical shape, dark ... Consumer surveys indicate that the shape of ... Christmas tree selection, followed by needle retention, species, ...
... ARTICLE #1 FOR IMMEDIATE RELEASE Evidence that inexpensive ... Energy & Fuels Amid sticker-shock fuel prices, researchers ... tests verifying that a simple, inexpensive device attached to a ... to 20 percent. That translates into several more precious miles ...
Cached Biology News:Carbon dioxide 'scrubber' captures greenhouse gases 2Carbon dioxide 'scrubber' captures greenhouse gases 3Consumers influence christmas tree styles 2American Chemical Society's Weekly PressPac -- Sept. 24, 2008 2American Chemical Society's Weekly PressPac -- Sept. 24, 2008 3American Chemical Society's Weekly PressPac -- Sept. 24, 2008 4American Chemical Society's Weekly PressPac -- Sept. 24, 2008 5American Chemical Society's Weekly PressPac -- Sept. 24, 2008 6American Chemical Society's Weekly PressPac -- Sept. 24, 2008 7American Chemical Society's Weekly PressPac -- Sept. 24, 2008 8
(Date:9/30/2014)... bio-mimicking analog of one of nature,s most efficient ... team led by Alejandro Briseno of the University ... in developing long-sought polymer architecture to boost power-conversion ... electronic devices. , Briseno, with colleagues and ... Stanford University and Dresden University of Technology, Germany, ...
(Date:9/30/2014)... 30, 2014 Shimadzu Scientific Instruments ... easy-to-use and highly precise tool for measuring displacement ... elongation. With 1000-mm maximum movement distance, the DSES-1000 ... a gauge length of 10 mm. In addition, ... above 50-mm stroke and within +/- 100 µm ...
(Date:9/30/2014)... Proove Biosciences , the commercial and ... a new genetic test built upon research from their ... will provide physicians with an objective way to ... are stratified between individuals. With this new test, physicians ... a genetic predisposition that will affect their pain tolerance. ...
(Date:9/30/2014)... -- CORD:USE Cord Blood Bank – www.corduse.com ... into an Equity and Exclusive Services Agreement with Tianhe Stem ... patented technologies for the isolation of human cord blood-derived ... performing Phase I/II clinical trials in China ... Tianhe,s Stem Cell Educator Therapy showing that the therapy ...
Breaking Biology Technology:Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Shimadzu’s New Long-Travel Extensometer Increases Precision for Soft Material Testing 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 4
... number of US clinics, CHICAGO, IL, Sept. ... first commercially available bionic hand, today revealed details ... Assembly of the American,Orthotic and Prosthetic Association (AOPA). ... RACE Team and Partner Program are designed to ...
... 10 /Xinhua-PRNewswire-FirstCall/ -- Yongye Biotechnology,International, Inc. (OTC ... leading developer, producer and distributor of nutrients ... of China, today announced that it closed ... led by,Black River Asset Management, pursuant to ...
... Discovery of New Class of Anti-Inflammatory ... ... of The,Dr. Paul Janssen Award for Biomedical Research, Professor Marc Feldmann,FMedSci, FAA, ... Institute of Rheumatology, Imperial College London, are,being honored during a scientific symposium ...
Cached Biology Technology:Touch Bionics unveils innovative partner and reimbursement programs at AOPA 2Touch Bionics unveils innovative partner and reimbursement programs at AOPA 3Yongye Biotechnology International Raises $9.4 Million in Private Placement 2Yongye Biotechnology International Raises $9.4 Million in Private Placement 3Johnson & Johnson Honors 2008 Recipients of The Dr. Paul Janssen Award for Biomedical Research 2Johnson & Johnson Honors 2008 Recipients of The Dr. Paul Janssen Award for Biomedical Research 3Johnson & Johnson Honors 2008 Recipients of The Dr. Paul Janssen Award for Biomedical Research 4
... Lambda Protein Phosphatase ( ... protein phosphatase with activity ... and tyrosine residues. It ... product of the ORF221 ...
Angiotensin Converting Enzyme [Porcine Kidney, ACE, Peptidyl-dipeptidase A]...
Oven mesh sheets, large, 23 x 23cm, pack of 5...
Preparation Note: Prepared essentially by method of Singer, T.P., J. Biol. Chem., 174, 11 (1948). Quality Clarifier: Contains lipase Unit Definition: One unit will hydrolyze 1.0 μmole of p-ni...
Biology Products: