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Ten genes identified in connection with sudden cardiac death
Date:3/22/2009

the balance of sodium and potassium moving in and out of the heart muscle is important, Abecasis said. "There's a couple where we don't really now what they do, so we're hoping maybe they will give us an interesting lead into other things.

"Each gene we identified can produce a small alteration in the QT interval," Abecasis said. "Individuals with too many genes predisposing to a long or short QT interval are likely to be most at risk of sudden cardiac death."

The next research phase will follow people over time and see which carriers have SCD or are at most risk, and how the changes in QT interval translate into changes in risk, Abecasis said.

Scientists studied DNA and electrocardiograms for 15,000 people, and contrasted their findings with those of a parallel study of similar size led by Chris Newton Cheh of the Broad Institute.


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Contact: Laura Bailey
baileylm@umich.edu
734-764-1848
University of Michigan
Source:Eurekalert

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