Navigation Links
Temple researchers uncover clues to how existing heart drugs work
Date:11/5/2013

(Philadelphia, PA) Some of the most commonly prescribed drugs for the treatment of heart failure are beta-blockers and nitrates, which help to relax blood vessels and decrease the heart's workload. The drugs were thought to produce those effects through distinct molecular pathways, but according to a new study led by scientists at Temple University School of Medicine, both types of drugs may help the failing heart by counteracting the effects of an enzyme known as GRK2. The findings suggest that new drugs aimed specifically at GRK2, which can trigger the death of heart cells, could protect the heart from progressive disease.

The study, which appears online October 29 in the journal Science Signaling, describes a previously uncharacterized interaction between GRK2 and an enzyme called endothelial nitric oxide synthase (eNOS), in which the two enzymes attempt to block one another's activity, with different outcomes on heart function.

"When eNOS is activated, GRK2 is inhibited, and good things happen [to the heart]," explained senior investigator Walter J. Koch, PhD, Professor and Chair of the Department of Pharmacology at Temple's School of Medicine and Director of the Center for Translational Medicine. In heart disease, however, the balance is flippedGRK2 is activated and eNOS is inhibited, which results in heart cell death and a loss in contractile function.

At the center of the GRK2 and eNOS interaction is nitric oxide (NO), the production of which is controlled by eNOS. Nitric Oxide protects the heart from damage caused by ischemia, or blocked blood flow to heart tissue. Exactly how it exerts its cardioprotective effects, however, has been a mystery.

To determine whether cardioprotection by NO was linked to GRK2 inhibition, Koch and colleagues conducted a series of experiments in mice. The most pivotal of those experiments involved the development of a novel "knock-in" mouse model in which a point mutation was intr
'/>"/>

Contact: Jeremy Walter
Jeremy.Walter@tuhs.temple.edu
215-707-7882
Temple University Health System
Source:Eurekalert

Page: 1 2

Related biology news :

1. Youthful stem cells from bone can heal the heart, Temple scientists report
2. Clues to heart disease in unexpected places, Temple researchers discover
3. Temple researchers discover key to heart failure, new therapies on horizon
4. Temple-Penn researchers identify calcium accelerator to keep cell power supply going
5. Losing protein helps heart recover, say Temple scientists
6. Researchers unmask centuries-old elephant imposter
7. Virginia Tech researchers explore natural way to displace harmful germs from household plumbing
8. Penn researchers identify molecular link between gut microbes and intestinal health
9. Researchers Able to Identify that Benign Tumors from Use of Oral Contraceptive Have a Greater Chance of Becoming Malignant
10. Children of lower socioeconomic status grow up more susceptible to catching colds, Carnegie Mellon researchers find
11. University of Louisville researchers sign global licensing agreement
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... Aug. 28, 2014  Privacy Advocate and Senior Staff ... Lynch , joins the lineup of biometric and mobile ... Biometrics UnPlugged Executive Summit in Tampa, Florida ... Previously announced speakers include Steven Rahman, Director, Technology and Strategy ... at Experian. The theme of this year,s event is ...
(Date:8/28/2014)... and imaging how quickly blood flows in the brain ... abuse affects the brain, which may aid in improving ... treatment options for recovering drug addicts. The new method, ... University in New York, USA and the U.S. National ... Society,s (OSA) open-access journal Biomedical Optics Express ...
(Date:8/28/2014)... pose a significant health risk to people with asthma according ... Allergy and Clinical Immunology . , By critically reviewing the ... has found that the presence of several types of mould ... as increasing the likelihood of developing the condition. , The ... of Exeter Medical School and is the first time all ...
Breaking Biology News(10 mins):Biometrics UnPlugged Welcomes the Electronic Frontier Foundation's Jennifer Lynch to the Mobility at the Crossroads of Commerce and Privacy Summit 2This is your brain's blood vessels on drugs 2This is your brain's blood vessels on drugs 3Indoor mold poses health risk to asthma sufferers 2
... new fungal species, called , Hebelomagriseopruinatum , has now ... fungus, whose name can be translated into ,the grey-dewy ... a mushroom-hunting tour headed by postdoc Jacob Heilman-Clausen from ... in 2009, postdoc Jacob Heilman-Clausen from the Center for ...
... with Primary Angle Closure Glaucoma (PACG), a leading cause ... people worldwide, 80% of whom live in Asia. ... Nature Genetics , on 26 August 2012, was ... Institute (SERI)/Singapore National Eye Centre (SNEC), Genome Institute of ...
... /PRNewswire-iReach/ -- IdentiSys Inc., North America,s largest sales ... emergency response and access control/CCTV security systems, ... Security and Presentation Divisions of Mountainland Business ... with additional offices in Idaho, Oregon, Nevada, ...
Cached Biology News:New Danish fungal species discovered 2Singapore scientists find genes associated with glaucoma, a major cause of eye blindness 2Singapore scientists find genes associated with glaucoma, a major cause of eye blindness 3IdentiSys acquires the Identification, Security and Presentation Divisions of Mountainland Business Systems, a Utah based reseller 2IdentiSys acquires the Identification, Security and Presentation Divisions of Mountainland Business Systems, a Utah based reseller 3
(Date:8/29/2014)... A major challenge before new biotechnology ... realm of Boston-Cambridge, is gaining visibility that can lead ... the Director of Boston’s Adult Stem Cell Technology Center, ... visibility of his company an important priority since he ... to a social media marketing campaign launched ...
(Date:8/28/2014)... 2014 Best Sanitizers, Inc., the first ... hand sanitizer, asks food processors and food handling professionals ... sanitizer they’re currently using to Best Sanitizers’ Alpet® ... critical to fighting cross-contamination and the spread of pathogens ... there are key criteria that make a hand sanitizer ...
(Date:8/28/2014)... , Aug. 28, 2014 ... a new market research report ... Whole Exome Sequencing ... (Library Preparation, Target Enrichment), by ... by Synthesis), by Application (Cancer, ...
(Date:8/28/2014)... 28, 2014 Sterlitech is proud to ... to its stable of products . These ... cut-offs and include membrane filters with surface charges. ... customer demand for our membrane process testing equipment, and ... flat sheet membranes,” explains Sterlitech President Mark Spatz. ...
Breaking Biology Technology:The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 3Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 4Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 5Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 6Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 7Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 8Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 9Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 10Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 11Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 12Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 13Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2
... A tiny scaffold-like titanium structure of Nanonets coated ... lighter and longer-lasting Lithium-ion batteries, according to a team ... material using nanotechnology. The web-like Nanonets developed in ... offer a unique structural strength, more surface area and ...
... , , , SAN DIEGO , ... BMR ) today announced the signing of an amendment to ... its 301 Binney Street laboratory research facility in Cambridge, Massachusetts ... of laboratory and office space contiguous to its existing premises located ...
... SAN FRANCISCO , Feb. 16 ... innovative new initiatives at Informex this week, highlighting the country,s ... the global chemicals industry. , At Informex 2010, Scotland ... seven leading universities, the private sector and the Scottish Government ...
Cached Biology Technology:Silicon-coated nanonets could build a better lithium-ion battery 2BioMed Realty Trust Expands Lease With Ironwood Pharmaceuticals for 50,000 Square Feet in Cambridge, Massachusetts 2BioMed Realty Trust Expands Lease With Ironwood Pharmaceuticals for 50,000 Square Feet in Cambridge, Massachusetts 3BioMed Realty Trust Expands Lease With Ironwood Pharmaceuticals for 50,000 Square Feet in Cambridge, Massachusetts 4Scotland Launches Chemicals Industry Partnerships To Propel $13 Billion Sector 2Scotland Launches Chemicals Industry Partnerships To Propel $13 Billion Sector 3Scotland Launches Chemicals Industry Partnerships To Propel $13 Billion Sector 4
... are fast multi-channel pipetting platforms consisting of ... with a multi-channel head and a robotic ... with true parallel processing of sample plates ... with the Freedom EVOware program. ...
... Freedom EVO384R are fast multi-channel pipetting platforms ... different sizes, with a multi-channel head and ... time saving, with true parallel processing of ... your assays with the Freedom EVOware program. ...
Prepared by multi-temperature ethanol fractionation with extensive charcoal treatment and dialysis.• Assay: ≥ 95 % (HPCE)• pH ~5.2 (10 mg/mL in 0.15 M NaCl)...
... Linkage: This CLS number is a ... match Cornings product number. If showing ... the old Sigma-Aldrich number (Z71,405-4) or ... Dim: diam. 60 mm volume ...
Biology Products: