Navigation Links
Temple-Penn researchers identify calcium 'accelerator' to keep cell power supply going
Date:11/25/2012

, and its activity level increases when the extra-mitochondrial calcium levels increase. When there is a high calcium level, say during a disease state, the MCUR1 senses this and facilitates the channel activity, dumping calcium inside," Dr. Madesh explained.

Calcium Control as a Targeted Therapeutic

Dr. Madesh explained that in some disease conditions such as ischemic reperfusion injury (tissue damage that occurs when blood returns to tissue after a period without oxygen), stroke involving brain injury from ischemia, and myocardial infarction calcium floods into the mitochondria. "The mitochondria have a massive membrane potential and grab external calcium. The mitochondria then are overloaded and rupture, leading to cell death and possible organ injury."

Because some diseases are characterized by an overabundance of calcium in the mitochondria, a possible therapy could involve slowing down the amount of calcium coming into the mitochondria. "We want to control the calcium entering the mitochondria," he said.

"Further studies already underway should reveal the precise molecular mechanisms by which MCUR1 accelerates the channel pore MCU, providing insights into mitochondrial bioenergetics," said first author Karthik Mallilankaraman, PhD, a postdoctoral fellow in the Department of Biochemistry and the Center for Translational Medicine at Temple University School of Medicine.


'/>"/>

Contact: Steven Benowitz
steven.benowitz@tuhs.temple.edu
215-707-4784
Temple University Health System
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2013)... predict the stability of today,s largest ice sheets in Greenland ... years ago, for example when Earth was going through ... a high sea level due to ice sheet collapse at ... that if the world,s largest ice sheets collapsed in the ... modern, progressively warming world. , However, a new groundbreaking ...
(Date:5/16/2013)... layer lining the body,s blood vessels, is extremely ... thickness, this super-tenuous structure routinely withstands blood flow, ... a unique and highly dynamic barrier that maintains ... body,s circulatory system. , It,s also extremely adaptable. ... breached to enable immune cells to reach ...
(Date:5/16/2013)... , May 16, 2013 Integrated ... combination with a custom thin film transistor camera ... forensic quality roll image in the smallest and ... Sherlock, an Appendix F Mobile ID FAP 45, ... 95% reduction in size and weight when compared ...
Breaking Biology News(10 mins):World's biggest ice sheets likely more stable than previously believed 2Endothelium, heal thyself 2Endothelium, heal thyself 3Endothelium, heal thyself 4
... the first time, scientists have described not only the identities ... in this case, a mouse macrophage or white blood ... and change over time to a bacterial stimulus triggering the ... of the Journal of Biological Chemistry , lead author ...
... of time, the colonial hydrology of the northeastern U.S. has ... social scientists. The results, which extend as far back ... the journal Environmental Science & Technology (ES&T). ... of the past, and will lead to a better understanding ...
... / ST. PAUL (December 1, 2010) University of ... is among an international group of researchers that has ... of sexual maturation in women. Many of these genes ... energy metabolism. Prior to the multi-institutional study, only four ...
Cached Biology News:Researchers describe first functioning 'lipidome' of mouse macrophage 2Researchers describe first functioning 'lipidome' of mouse macrophage 3America's colonial hydrologic history recreated 2U of M researcher helps unlock 30 new genes responsible for early onset puberty 2
(Date:5/17/2013)... ALTO, Calif. , May 17, 2013 /PRNewswire/ ... it has achieved 50% enrollment of the total ... to evaluate the safety and preliminary efficacy of ... Cells) therapy for Knee Osteoarthritis (KOA). To date ... (SAE) reported. The Phase I open ...
(Date:5/17/2013)... , May 17, 2013 /PRNewswire-iReach/ -- Aridis ... been reached with Switzerland -based ... anti-infective human monoclonal antibody (mAb) products, and technologies. ... mAb products for treatment of infections by common ... Staphylococcus aureus , Pseudomonas aeruginosa , ...
(Date:5/17/2013)... May 17, 2013 Men’s skin is biologically ... La-roche Posay ) and has been known to react more ... men may be far from puberty, other acne causing factors ... causing breakouts, and threatening skin with unsightly acne scars. Adult ... Men’s Health on how to reduce and prevent ...
(Date:5/17/2013)... RURO Inc. is pleased to ... versatile refinement to the smart management solution. , ... advanced methodical management for transgenic animal colonies, genotyping ... network-based platform provides user access with a plethora ... to emphasize streamlined tasks, such as animal relocation ...
Breaking Biology Technology:Cellular Biomedicine Group Achieves 50% Enrollment Milestone in Phase I Clinical Trial for Knee Osteoarthritis 2Aridis Pharmaceuticals Announces Acquisition of Monoclonal Antibody Products and Technologies From Kenta Biotech 2Aridis Pharmaceuticals Announces Acquisition of Monoclonal Antibody Products and Technologies From Kenta Biotech 3Adult Acne Treatment, Probiotic Action Shares New Insight on Why Men’s Skin Scars from Acne and How to Prevent It 2RURO Introduces ezColony 4.1 – The Versatile Transgenic Animal Colony Management Software 2
... VIENNA, Va., March 10 CEL-SCI Corporation (NYSE Alternext ... to launch a new manufacturing process that could allow ... to maintain their potency and thereby potentially also their ... developed by CEL-SCI may also significantly accelerate the time ...
... Take Market Share Away from Lucentis from 2012 ... Decision ResourcesWALTHAM, Mass., March 10 Decision Resources, ... firms for pharmaceutical and healthcare issues, finds that ... macular degeneration (AMD) market through 2012 will be ...
... Tolerx, Inc., today announced that DEFEND ( D urable ... arly or N ew Onset Type 1 D ... targeted immunotherapeutic, has begun enrollment of new onset autoimmune type ... cell function subsequent to the administration of otelixizumab is the ...
Cached Biology Technology:CEL-SCI Corporation to Launch Aseptic Filling for Stem Cell Produced Therapies and Other Biological Products 2CEL-SCI Corporation to Launch Aseptic Filling for Stem Cell Produced Therapies and Other Biological Products 3CEL-SCI Corporation to Launch Aseptic Filling for Stem Cell Produced Therapies and Other Biological Products 4Robust Annual Growth Through 2012 in the Age-Related Macular Degeneration Market Will Be Driven by Expanding Use of Lucentis in Europe 2Robust Annual Growth Through 2012 in the Age-Related Macular Degeneration Market Will Be Driven by Expanding Use of Lucentis in Europe 3Tolerx Expands Phase 3 'DEFEND' Trial of Otelixizumab in Europe 2Tolerx Expands Phase 3 'DEFEND' Trial of Otelixizumab in Europe 3Tolerx Expands Phase 3 'DEFEND' Trial of Otelixizumab in Europe 4
quantitation of phosphatase activity, evaluation of hits and leads from HTS...
... ISO 9001:2000 Certified USDA Research Registered ... SOP's Training AALAS Certified Technicians ... Procedures GLP Documentation Upon Request Focus ... point for all your custom immunology service ...
Request Info...
Request Info...
Biology Products: