Navigation Links
Telomeres resemble DNA fragile sites
Date:7/10/2009

omeres resembled common fragile sites, suggesting that TRF1 protects telomeres from becoming fragile. Instead of a continuous string of DNA, the telomeres were broken into fragments of twos and threes. To see if the replication fork stalls at telomeres, de Lange and Sfeir joined forces with Carl L. Schildkraut, a researcher at Albert Einstein College of Medicine in New York City. Using a technique called SMARD, the researchers observed the dynamics of replication across individual DNA molecules the first time this technique has been used to study telomeres. In the absence of TRF1, the fork often stalled for a considerable amount of time.

The only other known replication problem posed by telomeres was solved in 1985 when it was shown that the enzyme telomerase elongates telomeres, which shorten during every cell division. The second problem posed by telomeres, the so-called end-protection problem, was solved by de Lange and her colleagues when they found that shelterin protects the ends of linear chromosomes, which look like damaged DNA, from unnecessary repair. Working with TRF1, the very first shelterin protein ever to be identified, de Lange and Sfeir have not only unveiled a completely unanticipated replication problem at telomeres, they have also shown how it is solved.

The research lays new groundwork for the study of common fragile sites throughout the genome, explains de Lange. "Fragile sites have always been hard to study because no specific DNA sequence preceeds or follows them," she says. "In constrast, telomeres represent fragile sites with a known sequence, which may help us understand how common fragile sites break throughout the genome and why."


'/>"/>

Contact: Thania Benios
tbenios@rockefeller.edu
212-327-7146
Rockefeller University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Satellite imagery shows fragile Wilkins Ice Shelf destabilized
2. Promising new drug being evaluated as possible treatment option for fragile X syndrome
3. M.I.N.D. Institute researchers call for fragile X testing throughout the lifespan
4. UCR researchers propose minocycline as a promising drug for patients with Fragile X syndrome
5. Experts meet on need for new rules to govern worlds fragile polar regions
6. Researcher helping to pioneer medical therapy for Fragile X Syndrome presents latest findings
7. Effective ADHD treatment found for children with fragile X syndrome
8. Deep into the machinery of adult fragile X
9. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
10. Study finds role for parasites in evolution of sex
11. Immune genes adapt to parasites
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Telomeres resemble DNA fragile sites
(Date:9/2/2014)... 2014) In the battle between our immune systems ... in bacteria-killing viruses known as phages. In a new ... In Health, Haiti,s National Public Health Laboratory, and elsewhere, ... up their virulence in order to survive. Importantly, the ... that cholera,s mutational escape from phage predation occurs during ...
(Date:9/2/2014)... integrity? Tell the truth; everyone has a tipping point. We ... lie if the benefit is great enough. Now, scientists have ... that decision. , The result was published online this ... prefer to be honest, even if lying is beneficial," said ... at the Virginia Tech Carilion Research Institute , where ...
(Date:9/2/2014)... September 2, 2014 Best-selling author Sam Kean stops ... the Megalodon, the 50-foot super shark that, despite what ... extinct. Learn all about it at http://youtu.be/KhFygIoW_MA . ... Tales of Madness, Love and the History of the ... getting the Reactions treatment in a 10-episode video series ...
Breaking Biology News(10 mins):War between bacteria and phages benefits humans 2War between bacteria and phages benefits humans 3Scientists find possible neurobiological basis for tradeoff between honesty, self-interest 2Scientists find possible neurobiological basis for tradeoff between honesty, self-interest 3Scientists find possible neurobiological basis for tradeoff between honesty, self-interest 4
... population lives in areas at risk of malaria transmission. ... and each year causes hundreds of thousands of deaths worldwide, ... The malaria-causing parasite, Plasmodium falciparum , is spread ... human blood. P. falciparum invades red blood ...
... impressive feat of nature, where plants harvest light energy ... at fantastically high efficiency. Indeed modern civilization became possible ... and clothing. While scientists have been able ... plants store solar energy as chemical energy, how developing ...
... 3, 2010 -- The latest discoveries and innovations in ... be presented this month at a major scientific conference ... aids, new technologies for monitoring fetal heartbeats, intriguing explorations ... the social lives of dolphins. The 2nd Pan-American/Iberian ...
Cached Biology News:UC Riverside cell biologist to investigate how malaria parasite multiplies in red blood cells 2The developmental dynamics of the maize leaf transcriptome 2Highlights from major acoustical science and technology conference, Nov. 15-19 2Highlights from major acoustical science and technology conference, Nov. 15-19 3Highlights from major acoustical science and technology conference, Nov. 15-19 4Highlights from major acoustical science and technology conference, Nov. 15-19 5Highlights from major acoustical science and technology conference, Nov. 15-19 6Highlights from major acoustical science and technology conference, Nov. 15-19 7Highlights from major acoustical science and technology conference, Nov. 15-19 8Highlights from major acoustical science and technology conference, Nov. 15-19 9Highlights from major acoustical science and technology conference, Nov. 15-19 10Highlights from major acoustical science and technology conference, Nov. 15-19 11Highlights from major acoustical science and technology conference, Nov. 15-19 12Highlights from major acoustical science and technology conference, Nov. 15-19 13
(Date:9/2/2014)... , Sept. 2, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ... $2.1 million. The orders consist of three large odour control ... . "These orders are consistent with the ... Peter Bruijns , President and CEO. "After a difficult ... we are now beginning to see sales growth. Our lower ...
(Date:9/1/2014)... NEW YORK , Sept. 1, 2014 /PRNewswire/ ... report is available in its catalogue: ... Opportunities, 2019 http://www.reportlinker.com/p02350445/India-Solid-Waste-Management-Vehicles-Market-Forecast-and-Opportunities-2019.html ... municipal corporations are the main governing bodies responsible ... management in cities. On an average, around 135,000 ...
(Date:8/31/2014)... 2014 2014 Market Research ... professional and in-depth research report on the ... information, including Polyacrylamide definition, classification, application, and ... overview. This research covers the international market ... global industry analysis covering macroeconomic environment & ...
(Date:8/29/2014)... The global companion diagnostics market ... It is expected to grow at a CAGR ... valued at $1.8 billion in 2013, according to ... , For more information regarding analysis details and ... research report, titled “Companion Diagnostics Market (Breast Cancer, ...
Breaking Biology Technology:India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 4India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 5India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 6India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 7India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 8International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 2International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 3Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3
... for Critical Path Immunology created to discover and develop ... biomarkers for immune system-related diseases -, SAN FRANCISCO, March ... collaboration with Beckman Coulter, Inc. to,establish a Center for Critical ... in disease. This facility, which will be managed by,ITI and ...
... Patents Filed on Lead Compounds That Directly and Specifically Activate ... ... WOBURN, Massachusetts, March 31 Mercury Therapeutics,Inc. (MTI), a company ... it has filed for patent protection on,three lead compounds that directly ...
... ... development activities, MEDFORD, Mass. and ... unique microfluidic microarray system Geniom,today announced the formation of a ... of genetics and genomics,research. The SAB members, from top research ...
Cached Biology Technology:The Immune Tolerance Institute Announces Collaboration with Beckman Coulter Establishing a Multiplatform Immunophenotyping/Immunogenotyping Laboratory 2The Immune Tolerance Institute Announces Collaboration with Beckman Coulter Establishing a Multiplatform Immunophenotyping/Immunogenotyping Laboratory 3Mercury Therapeutics Patents Filed 2Mercury Therapeutics Patents Filed 3febit Forms Scientific Advisory Board 2febit Forms Scientific Advisory Board 3
Request Info...
Anti-ZFP200 Family: Zinc Finger Peptide Sequence: CGKSFNHKTNLNKHER...
Donor feline serum and plasma...
Collected from sexually mature, mixed sex, mixed breed cats. Physiochemical constituents are measured to ensure lot-to-lot consistency....
Biology Products: