Navigation Links
Telomeres resemble DNA fragile sites
Date:7/10/2009

Telomeres, the repetitive sequences of DNA at the ends of linear chromosomes, have an important function: They protect vulnerable chromosome ends from molecular attack. Researchers at Rockefeller University now show that telomeres have their own weakness. They resemble unstable parts of the genome called fragile sites where DNA replication can stall and go awry. But what keeps our fragile telomeres from falling apart is a protein that ensures the smooth progression of DNA replication to the end of a chromosome.

The research, led by Titia de Lange, head of the Laboratory of Cell Biology and Genetics, and first author Agnel Sfeir, a postdoctoral associate in the lab, suggests a striking similarity between telomeres and common fragile sites, parts of the genome where breaks tend to occur, albeit infrequently. (Humans have 80 common fragile sites, many of which have been linked to cancer.) De Lange and Sfeir found that these newly discovered fragile sites make it difficult for DNA replication to proceed, a discovery that unveils a new replication problem posed by telomeres.

At the center of the discovery is a protein known as TRF1, which de Lange, in an effort to understand how telomeres protect chromosome ends, discovered in 1995. Using a conditional mouse knockout, de Lange and Sfeir have now revealed that TRF1, which is part of a six-protein complex called shelterin, enables DNA replication to drive smoothly through telomeres with the aid of two other proteins.

"Telomeric DNA has a repetitive sequence that can form unusual DNA structures when the DNA is unwound during DNA replication," says de Lange. "Our data suggest that TRF1 brings in two proteins that can take out these structures in the telomeric DNA. In other words, TRF1 and its helpers remove the bumps in the road so that the replication fork can drive through."

The work, published in the July 10 issue of Cell, began when Sfeir deleted TRF1 and saw that the tel
'/>"/>

Contact: Thania Benios
tbenios@rockefeller.edu
212-327-7146
Rockefeller University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Satellite imagery shows fragile Wilkins Ice Shelf destabilized
2. Promising new drug being evaluated as possible treatment option for fragile X syndrome
3. M.I.N.D. Institute researchers call for fragile X testing throughout the lifespan
4. UCR researchers propose minocycline as a promising drug for patients with Fragile X syndrome
5. Experts meet on need for new rules to govern worlds fragile polar regions
6. Researcher helping to pioneer medical therapy for Fragile X Syndrome presents latest findings
7. Effective ADHD treatment found for children with fragile X syndrome
8. Deep into the machinery of adult fragile X
9. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
10. Study finds role for parasites in evolution of sex
11. Immune genes adapt to parasites
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Telomeres resemble DNA fragile sites
(Date:3/24/2015)... Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) ... Recognition Market 2015-2019" report to their offering. ... to grow at a CAGR of 23.5 percent over ... present scenario and the growth prospects of the Global ... the market size, the report considers the revenue generated ...
(Date:3/23/2015)... YORK , March 23, 2015   HOYOS ... property management company, today announced that the Company will ... for both enterprise and consumers at Connect:ID on March ... HOYOS Labs will highlight the IEEE Biometric ... TM ; and enterprise access control system. BOPS ...
(Date:3/20/2015)... , March 20, 2015 NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... wallet is one of the products featured in 2015 ... 20th at 11:00 PM EST on the DIY Network. ... Las Vegas , site of the ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3
... that in which they exist naturally, proteins and multiprotein ... they exhibit when in the static form in which ... College of Medicine in a report in the current ... study using electron cryomicroscopy, Dr. Steven Ludtke, assistant professor ...
... place is not a Rudyard Kipling “Just So?story, but an ... results. For a chicken, it’s the difference between having feathers ... of Southern California and mathematicians at Oxford University in the ... To understand patterning on the molecular and the systems level, ...
... novel way of combating diseases related to the immune system, ... and arthritis. The study, funded by the Wellcome Trust, appears ... by the body to fight infection. Scientists previously identified two ... T cells", which attack infected cells, and "regulatory T cells", ...
Cached Biology News:Embryonic patterning makes the feathers fly 2T for two: Scientists show how immune system chooses best way to fight infection 2
(Date:3/25/2015)... March 25, 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or ... a result of recent discussions with certain shareholders representing ... the Company, after dealing with certain matters including the ... of shareholders on March 26, 2015 (the "Meeting") it ... of directors will take place when the Meeting reconvenes. ...
(Date:3/25/2015)... , March 25, 2015  S&P Capital ... Factual Stock Report coverage on Abattis Bioceuticals ... ATTBF; CSE: ATT): is a specialty biotechnology company ... cultivating, licensing and marketing proprietary ingredients, bio-similar compounds, ... in North America . The ...
(Date:3/25/2015)... SHANGHAI , CAMBRIDGE, Mass. and ... -- WuXi NextCODE, which provides comprehensive capabilities for using the ... deCODE genetics on their publication of the largest studies of ... published today online in Nature Genetics ... date of sequence variation, authored by a team of deCODE ...
(Date:3/25/2015)... Francisco, CA (PRWEB) March 25, 2015 ... Support for Novel Mechanism of Action in Neuromuscular ... 25, 2015 – Cytokinetics, Incorporated (Nasdaq: CYTK) announced ... fast skeletal muscle troponin activator tirasemtiv in the ... a Phase IIa “Evidence of Effect” or hypothesis-generating ...
Breaking Biology Technology:SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 2SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 3SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 4SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 5S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 2S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 3S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 4S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 5Landmark deCODE Studies Demonstrate the Power of Truly Big Genomics for Improving Medicine Worldwide 2Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 2Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 3Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 4Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 5Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 6
... 2012  Patients with gynecologic cancer have new hope in ... Center at University Hospitals (UH) Case Medical Center.  A ... is among the first in the nation to launch ... treat ovarian, endometrial and select other cancers. ...
... N.J., Jan. 20, 2012  Insmed Incorporated (Nasdaq CM: ... U.S. Food and Drug Administration (FDA) has lifted ... amikacin for inhalation) in patients with non-tuberculous mycobacteria ... discussions with FDA regarding the clinical hold placed ...
... N.Y., Jan. 19, 2012  Netsmart, the leading provider ... organizations nationwide, today announced the launch of ... highlight the positive clinical and financial impacts provided ... (Logo: http://photos.prnewswire.com/prnh/20110620/NY22778LOGO ) In ...
Cached Biology Technology:UH Case Medical Center Offers New Therapy for Gynecologic Cancer Patients 2UH Case Medical Center Offers New Therapy for Gynecologic Cancer Patients 3Insmed Incorporated Provides Corporate Update 2Insmed Incorporated Provides Corporate Update 3EveryDayMatters.com Aims to Raise Awareness and Coordinate Care Between Mental and Physical Health 2EveryDayMatters.com Aims to Raise Awareness and Coordinate Care Between Mental and Physical Health 3
Whole blood is collected from healthy guinea pigs of either sex from US source which are free of visible diseases at time of blood collection. Hemolytic titer: CH50 = 435 units...
Luminometers...
cDNA Size Fractionation Columns offer an efficient and convenient method for size-fractioning double-stranded cDNA....
Homo sapiens inhibin, beta B (activin AB beta polypeptide) Antigen: Recombinant Protein(142~254aa)...
Biology Products: