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Tel Aviv University President Co-authors Important Paper Unraveling the Effect of Spatial Organization on Intracellular Chemistry

an> 06 University, tackled the problem by universalizing Albert Einstein's mathematical model for the diffusion of randomly moving particles suspended in a fluid (known as Brownian motion, this process may be exemplified by a drop of ink spreading in a glass of water).

Coining the new phrase "geometry-controlled kinetics," the researchers argue that geometry, in particular the initial distance between reactants in so-called compact systems, can become a key parameter in mathematical models for processes as varied as regular diffusion, anomalous diffusion and diffusion in disordered media and fractals. Their findings are of special significance for understanding the crucial role of the complex spatial organization of living cells in general, and genes in particular - where molecules of DNA, RNA and other proteins must travel, meet and react with one another quickly and effectively in order to sustain life.

Most importantly, this analysis provides scientists with new tools for investigating the effects of existing medications on cells, as well as developing drugs that are tailored to every patient. In the long run, it may even facilitate genetic manipulation procedures, in which defective genes will be replaced with healthy ones - a possible future cure for some devastating genetic diseases.

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