Navigation Links
Tel Aviv University President Co-authors Important Paper Unraveling the Effect of Spatial Organization on Intracellular Chemistry
Date:4/22/2010

TEL AVIV, Israel, April 22, 2010 /PRNewswire/ -- Tel Aviv University President Professor, Joseph Klafter, has co-authored a paper that brings together a myriad of seemingly unrelated chemical reactions creating a unified picture of reaction kinetics. "Geometry-Controlled Kinetics," published in Nature Chemistry on April 18, contributes to our understanding of how the geometry of a particular medium affects the motion of molecules or other particles within that medium, determining how likely they are to actually meet and react chemically with one another. Applied to living cells, this new insight may serve as fertile ground for the development of new medications. The questions addressed by the paper's authors may be likened to the following situation: Two friends have agreed to meet during the break of a football match in the stadium's coffee bar to have coffee together. How likely is this rendezvous to take place before the break is over, and what does this depend upon? Among other things, claim the researchers, the meeting depends upon some geometrical parameters, such as the size of the stadium (or cell), how crowded it is and how far apart the two friends (or molecules) are situated initially.

(Photo: http://www.newscom.com/cgi-bin/prnh/20100422/387674 )

Professor Klafter, a world-renowned expert on the random motion of molecules and other nanometric particles, and his colleagues from the Department of Theoretical Solid State Physics at Paris 06 University, tackled the problem by universalizing Albert Einstein's mathematical model for the diffusion of randomly moving particles suspended in a fluid (known as Brownian motion, this process may be exemplified by a drop of ink spreading in a glass of water).

Coining the new phrase "geometry-controlled kinetics," the researchers argue that geometry, in particular the initial distance between reactants in so-called compact systems, can become a key parameter in mathematical models for processes as varied as regular diffusion, anomalous diffusion and diffusion in disordered media and fractals. Their findings are of special significance for understanding the crucial role of the complex spatial organization of living cells in general, and genes in particular - where molecules of DNA, RNA and other proteins must travel, meet and react with one another quickly and effectively in order to sustain life.

Most importantly, this analysis provides scientists with new tools for investigating the effects of existing medications on cells, as well as developing drugs that are tailored to every patient. In the long run, it may even facilitate genetic manipulation procedures, in which defective genes will be replaced with healthy ones - a possible future cure for some devastating genetic diseases.

    Link to the article:
http://www.nature.com/nchem/journal/vaop/ncurrent/abs/nchem.622.html

    Contact:

    Orly Fromer
    Media consultant
    Director of Media Relations and Spokesperson
    Tel-Aviv University
    Ramat Aviv 69978 Tel-Aviv, Israel
    Office: +972-3-6408741 & 6424020
    Fax: +972-3-6408355
    Mobile: +972-52-4737373
    E-mail: fromer@post.tau.ac.il
    Website: http://www.tau.ac.il



'/>"/>
SOURCE Tel-Aviv University
Copyright©2010 PR Newswire.
All rights reserved

Related biology news :

1. A study by the MUHC and McGill University opens a new door to understanding cancer
2. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
3. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
4. Bioengineers at University of Pennsylvania devise nanoscale system to measure cellular forces
5. Binghamton University researchers investigate evolving malaria resistance
6. Antioxidant to retard wrinkles discovered by Hebrew University researcher
7. Society for General Microbiology 161st Meeting, University of Edinburgh
8. Boston University biomedical engineers find chink in bacterias armor
9. KAUST and American University in Cairo to collaborate on research and academic development
10. UNH becomes first university in nation to use landfill gas as primary energy source
11. University of Minnesota study refutes belief that black men have more aggressive prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... 2, 2016  Based on its recent analysis ... recognizes US-based Intelligent Retinal Imaging Systems (IRIS) with ... for New Product Innovation. IRIS, a prominent cloud-based ... America , is poised to set the ... retinopathy market. The IRIS technology presents superior price-performance ...
(Date:1/28/2016)... (NASDAQ: SYNA ), a leading developer of human interface solutions, ... 2015. --> --> Net ... compared to the comparable quarter last year to $470.5 million. Net ... or $0.93 per diluted share. --> ... fiscal 2016 grew 9 percent over the prior year period to ...
(Date:1/22/2016)... 2016 http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ... the  "Global Behavioral Biometric Market 2016-2020" ... http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced the ... Market 2016-2020"  report to their offering. ... http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced the addition ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... ... February 10, 2016 , ... Benchmark Research, ... the promotion of two long-standing principal investigators (PI) to the roles of Chief ... and Development. , Dr. Laurence Chu, a Benchmark Research PI in the Austin ...
(Date:2/10/2016)... ... February 10, 2016 , ... SonaCare ... training and support program, Sonalink™ remote monitoring. The inaugural launch of this new ... February 5th, connecting Dr. Samuel Peretsman to a HIFU technical expert at SonaCare ...
(Date:2/10/2016)... ... February 10, 2016 , ... Global Stem Cells ... with Singapore-based Global Stem Cells Network (GSCN) and its affiliate Global Medical ... the latest adipose and bone marrow therapies. , Through the new collaboration, ...
(Date:2/9/2016)... ... 09, 2016 , ... With a presidential election in November and the future ... bring together over 500 top healthcare leaders for a night and day of debates ... by MBA students of the University of Pennsylvania’s Wharton School, will be held February ...
Breaking Biology Technology: