Navigation Links
Tel Aviv University President Co-authors Important Paper Unraveling the Effect of Spatial Organization on Intracellular Chemistry

TEL AVIV, Israel, April 22, 2010 /PRNewswire/ -- Tel Aviv University President Professor, Joseph Klafter, has co-authored a paper that brings together a myriad of seemingly unrelated chemical reactions creating a unified picture of reaction kinetics. "Geometry-Controlled Kinetics," published in Nature Chemistry on April 18, contributes to our understanding of how the geometry of a particular medium affects the motion of molecules or other particles within that medium, determining how likely they are to actually meet and react chemically with one another. Applied to living cells, this new insight may serve as fertile ground for the development of new medications. The questions addressed by the paper's authors may be likened to the following situation: Two friends have agreed to meet during the break of a football match in the stadium's coffee bar to have coffee together. How likely is this rendezvous to take place before the break is over, and what does this depend upon? Among other things, claim the researchers, the meeting depends upon some geometrical parameters, such as the size of the stadium (or cell), how crowded it is and how far apart the two friends (or molecules) are situated initially.

(Photo: )

Professor Klafter, a world-renowned expert on the random motion of molecules and other nanometric particles, and his colleagues from the Department of Theoretical Solid State Physics at Paris 06 University, tackled the problem by universalizing Albert Einstein's mathematical model for the diffusion of randomly moving particles suspended in a fluid (known as Brownian motion, this process may be exemplified by a drop of ink spreading in a glass of water).

Coining the new phrase "geometry-controlled kinetics," the researchers argue that geometry, in particular the initial distance between reactants in so-called compact systems, can become a key parameter in mathematical models for processes as varied as regular diffusion, anomalous diffusion and diffusion in disordered media and fractals. Their findings are of special significance for understanding the crucial role of the complex spatial organization of living cells in general, and genes in particular - where molecules of DNA, RNA and other proteins must travel, meet and react with one another quickly and effectively in order to sustain life.

Most importantly, this analysis provides scientists with new tools for investigating the effects of existing medications on cells, as well as developing drugs that are tailored to every patient. In the long run, it may even facilitate genetic manipulation procedures, in which defective genes will be replaced with healthy ones - a possible future cure for some devastating genetic diseases.

    Link to the article:


    Orly Fromer
    Media consultant
    Director of Media Relations and Spokesperson
    Tel-Aviv University
    Ramat Aviv 69978 Tel-Aviv, Israel
    Office: +972-3-6408741 & 6424020
    Fax: +972-3-6408355
    Mobile: +972-52-4737373

SOURCE Tel-Aviv University
Copyright©2010 PR Newswire.
All rights reserved

Related biology news :

1. A study by the MUHC and McGill University opens a new door to understanding cancer
2. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
3. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
4. Bioengineers at University of Pennsylvania devise nanoscale system to measure cellular forces
5. Binghamton University researchers investigate evolving malaria resistance
6. Antioxidant to retard wrinkles discovered by Hebrew University researcher
7. Society for General Microbiology 161st Meeting, University of Edinburgh
8. Boston University biomedical engineers find chink in bacterias armor
9. KAUST and American University in Cairo to collaborate on research and academic development
10. UNH becomes first university in nation to use landfill gas as primary energy source
11. University of Minnesota study refutes belief that black men have more aggressive prostate cancer
Post Your Comments:
(Date:11/9/2015)... DUBLIN , Nov. 09, 2015 /PRNewswire/ ... announced the addition of the "Global ... to their offering. --> ... "Global Law Enforcement Biometrics Market 2015-2019" ... Research and Markets ( ) ...
(Date:11/4/2015)... New York , November 4, 2015 ... to a new market report published by Transparency Market ... Share, Growth, Trends and Forecast 2015 - 2022", the global ... of US$ 30.3 bn by 2022. The market is ... the forecast period from 2015 to 2022. Rising security ...
(Date:10/29/2015)... 29, 2015   MedNet Solutions , an innovative ... of clinical research, is pleased to announce that it ... (MHTA) as one of only three finalists for a ... Small and Growing" category. The Tekne Awards honor ... superior technology innovation and leadership. iMedNet™ ...
Breaking Biology News(10 mins):
(Date:11/27/2015)... 2015 --> ... companion diagnostics is one of the major ... pharmaceutical companies and diagnostic manufacturers working together ... . --> ... global cancer biomarkers market spread across 89 ...
(Date:11/25/2015)... Nov. 25, 2015  PharmAthene, Inc. (NYSE MKT: PIP) ... a stockholder rights plan (Rights Plan) in an effort ... carryforwards (NOLs) under Section 382 of the Internal Revenue ... PharmAthene,s use of its NOLs could be substantially ... defined in Section 382 of the Code. In general, ...
(Date:11/25/2015)...  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) announced ... of Neurocrine Biosciences, will be presenting at the 27th ... York . .   ... minutes prior to the presentation to download or install ... be available on the website approximately one hour after ...
(Date:11/25/2015)... PORTLAND, Oregon , November 25, 2015 /PRNewswire/ ... Deep Market Research Report is a professional and ... Genomics industry.      (Logo: ... basic overview of the industry including definitions, classifications, ... analysis is provided for the international markets including ...
Breaking Biology Technology: