Navigation Links
Technique yields potential biological substitute for dental implants
Date:5/24/2010

NEW YORK (May 24, 2010) - A technique pioneered in the Tissue Engineering and Regenerative Medicine Laboratory of Dr. Jeremy Mao, the Edward V. Zegarelli Professor of Dental Medicine at Columbia University Medical Center, can orchestrate stem cells to migrate to a three-dimensional scaffold infused with growth factor, holding the translational potential to yield an anatomically correct tooth in as soon as nine weeks once implanted.

People who have lost some or all of their adult teeth typically look to dentures, or, more recently, dental implants to improve a toothless appearance that can have a host of unsettling psycho-social ramifications. Despite being the preferred (but generally painful and potentially protracted) treatment for missing teeth nowadays, dental implants can fail and are unable to "remodel" with surrounding jaw bone that undergoes necessary changes throughout a person's life.

An animal-model study has shown that by homing stem cells to a scaffold made of natural materials and integrated in surrounding tissue, there is no need to use harvested stem cell lines, or create an environment outside of the body (e.g., a Petri dish) where the tooth is grown and then implanted once it has matured. The tooth instead can be grown "orthotopically," or in the socket where the tooth will integrate with surrounding tissue in ways that are impossible with hard metals or other materials.

"These findings represent the first report of regeneration of anatomically shaped tooth-like structures in vivo, and by cell homing without cell delivery," Dr. Mao and his colleagues say in the paper. "The potency of cell homing is substantiated not only by cell recruitment into scaffold microchannels, but also by the regeneration of periodontal ligaments and newly formed alveolar bone."

This study is published in the most recent Journal of Dental Research, the top-rated, peer-reviewed scientific journal dedicated to the dissemination
'/>"/>

Contact: Alex Lyda
alyda@columbia.edu
212-305-0820
Columbia University Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. New technique can be breakthrough for early cancer diagnosis
2. University of Leicester scientists discover technique to help friendly bacteria
3. New technique reveals subtle force-induced changes in biomolecules conformation
4. New magnetic separation technique might detect multiple pathogens at once
5. New technique captures chemical reactions in a single living cell at unprecedented resolution
6. Software Techniques Inc. Selects M2SYS Fingerprint Software to Meet Continuous Growth and Demand for Desktop Biometric Time & Attendance Solutions
7. New X-ray technique targets terrorists and tumors
8. Technique controls nanoparticle size, makes large numbers
9. New technique could dramatically lower costs of DNA sequencing
10. New techniques create butanol
11. New radar satellite technique sheds light on ocean current dynamics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... Tanzania is playing a vital role in the survival ... response to climate and environmental changes, according to new ... on savannah birds from the Tanzanian Bird Atlas project ... decades - the researchers found that they are using ... areas further west where dry seasons are getting longer, ...
(Date:6/19/2013)... Science Consortium (PISC) is extremely disappointed that the ... upheld a decision that requires Dow Benelux B.V.to ... The study will use approximately 1160 animals and ... the substance dipropylene glycol methyl ether acetate (DPMA) ... Regulation on the Registration, Evaluation, Authorisation and Restriction ...
(Date:6/19/2013)... A team of researchers at the University of ... outer coating of HIV, that could be potential ... avoid generating resistance. These new agents are quite ... The research was published in the June 2013 ... Chemotherapy . , The first of many probable ...
Breaking Biology News(10 mins):Protected areas provide African birds with stepping stones to survival 2HIV-derived antibacterial shows promise against drug-resistant bacteria 2
... , ANN ARBOR, Mich.---Air pollution from industrial sources ... academic success, according to a new study from ... that schools located in areas with the state,s ... attendance rates---an indicator of poor health---as well as ...
... New findings from University of Utah School of Medicine researchers show ... of patients who have chronic fatigue syndrome (CFS). These findings ... CFS to XMRV. The study, performed by a team of ... associate professor of pathology, was published May 4, 2011, in the ...
... FASEB MARC (Minority Access to Research Careers) Program ... Genetics Society of America (GSA) Mouse Genetics conference in ... are meant to promote the entry of underrepresented minority ... basic science community and to encourage the participation of ...
Cached Biology News:Air pollution near Michigan schools linked to poorer student health, academic performance 2Air pollution near Michigan schools linked to poorer student health, academic performance 3Air pollution near Michigan schools linked to poorer student health, academic performance 4Comprehensive study finds no link between XMRV retrovirus and chronic fatigue syndrome 2Comprehensive study finds no link between XMRV retrovirus and chronic fatigue syndrome 3
(Date:6/19/2013)... Biotechnology industry pioneer Amgen (NASDAQ: ... BlackLine Systems  and enterprise application software leader ... webinar next week entitled "No Account Left Behind!  ... to Help Keep Its Account Reconciliations in Good Shape ... The webinar, geared at finance, accounting, audit and compliance ...
(Date:6/19/2013)... 2013 India’s vast and growing ... be worth up to a billion dollars per ... government is taking serious action to better regulate ... This presentation will examine:, ,     Recent ...     Immediate and long term impacts ,     Foreseeable ...
(Date:6/19/2013)... 19, 2013 Express Diagnostics Int’l, Inc., ... announced that it has received Class III medical device ... its DrugCheck® NxStep Onsite Drug Screen Cup ... rapid screening device in near-patient settings, such as physicians’ ... received Health Canada Class III approval for 24 different ...
(Date:6/18/2013)... A million electric cars could be on roads across North ... of research by the United States Department of Energy, Los ... Zhongwei Chen is part of a team led by the ... replace the expensive platinum catalysts in fuel cells. , "One ... in vehicles is the cost of the units. The pure ...
Breaking Biology Technology:Amgen Joins BlackLine Systems, SAP for Webinar on Automating Account Reconciliations 2Amgen Joins BlackLine Systems, SAP for Webinar on Automating Account Reconciliations 3Amgen Joins BlackLine Systems, SAP for Webinar on Automating Account Reconciliations 4Express Diagnostics’ DrugCheck® On-site Test Cup Receives Health Canada Class III Medical Device Approval 2Express Diagnostics’ DrugCheck® On-site Test Cup Receives Health Canada Class III Medical Device Approval 3US and Canadian researchers drive towards cheaper fuel cells for electric cars 2
... conductivities seen in metal wires, and that may light up ... researchers. A Rice lab made such a cable from ... standard line voltage -- a true test of the novel ... the future. The work appears this week in ...
... Sept. 7, 2011 Cellectis (Alternext: ALCLS), ... that its nuclease production capacity has increased ... Industrialization of the nuclease manufacturing gives Cellectis ... subsidiary of Cellectis, the potential to supply ...
... 2011 Ardea Biosciences, Inc. (Nasdaq: RDEA ) ... with the U.S. Food and Drug Administration (FDA) and successfully ... lesinurad Phase 3 development plan: the overall size and design ... the total safety database proposed for NDA filing, manufacturing plans ...
Cached Biology Technology:Rice researchers power line-voltage light bulb with nanotube wire 2Cellectis Announces a Ten-Fold Increase in Nuclease Production Capacity in 2011 2Ardea Biosciences Announces Positive End-of-Phase 2 Meetings with FDA for Lesinurad 2Ardea Biosciences Announces Positive End-of-Phase 2 Meetings with FDA for Lesinurad 3Ardea Biosciences Announces Positive End-of-Phase 2 Meetings with FDA for Lesinurad 4Ardea Biosciences Announces Positive End-of-Phase 2 Meetings with FDA for Lesinurad 5
Bovine Brain Microvascular Endothelial Cells (BBMVEC) (>500,000 cells)...
The improved design and new mechanical solutions of Finnpipette Focus Multichannel Plus improves accuracy and precision.In these low volume multichannel pipettes, the super blow-out function ensures ...
... Physical Form: buffered aqueous solution. ... terminal galactose from complex carbohydrates and glycoproteins. ... galactose under conditions where the pH must ... live cells. Unit Definition: ...
... is specific for human cardiac troponin subunit T, ... signals responsible for contraction of cardiac muscle. It ... in human cells. It also cross-reacts with human ... Antigen: Highly purified human cardiac troponin ...
Biology Products: