Navigation Links
Technique to reattach teeth using stem cells developed at UIC
Date:9/29/2010

A new approach to anchor teeth back in the jaw using stem cells has been developed and successfully tested in the laboratory for the first time by researchers at the University of Illinois at Chicago.

The new strategy represents a potential major advance in the battle against gum disease, a serious infection that eventually leads to tooth loss. About 80 percent of U.S. adults suffer from gum disease, according to the National Institute of Dental and Craniofacial Research.

Researchers in UIC's Brodie Laboratory for Craniofacial Genetics used stem cells obtained from the periodontal ligament of molars extracted from mice, expanded them in an incubator, and then seeded them on barren rat molars. The stem cell-treated molars were reinserted into the tooth sockets of rats.

After two and four months, the stem cells aligned and formed new fibrous attachments between the tooth and bone, firmly attaching the replanted tooth into the animal's mouth, said Smit Dangaria, a bioengineering doctoral candidate who conducted the research. Tissue sections showed that the replanted tooth was surrounded by newly formed, functional periodontal ligament fibers and new cementum, the essential ingredients of a healthy tooth attachment.

In contrast, tooth molars that were replanted without new stem/progenitor cells were either lost or loosely attached and were resorbed, Dangaria said.

The study, published in an online issue of the journal Tissue Engineering, was funded through a grant by the National Institutes of Health.

Dangaria said the natural surface of the tooth played an essential role in the study.

"Our research uncovered the code required to reattach teeth -- a combination of natural tooth root surface structure together with periodontal progenitor cells," he said.

To verify that the ligament was formed by the transplanted stem cells and not by the animal's own cells, stem cells were labeled with green fluorescent protein prior to seeding them on the molars and re-inserting the teeth into the animal's mouth, Dangaria said.

According to Tom Diekwisch, director of the Brodie Laboratory, who is senior author on the paper, this is the first progenitor cell-based regeneration of a complete periodontal ligament in which a functional tooth was attached.

"Our strategy could be used for replanting teeth that were lost due to trauma or as a novel approach for tooth replacement using tooth-shaped replicas," said Diekwisch, who is also professor and head of oral biology.


'/>"/>

Contact: Sam Hostettler
samhos@uic.edu
312-355-2522
University of Illinois at Chicago
Source:Eurekalert

Related biology news :

1. New oil detection technique
2. New technique uncovers hidden insecticide resistance
3. Caltech chemists develop simple technique to visualize atomic-scale structures
4. NSF awards $10M to develop computing techniques for measuring and analyzing child behavior
5. Optical imaging technique for angioplasty
6. New tagging technique enhances view of living cells
7. Hips dont lie: Researchers find more accurate technique to determine sex of skeletal remains
8. New technique improves efficiency of biofuel production
9. Cheap, simple, noninvasive blood test may replace invasive diagnostic techniques in early pregnancy
10. Technique enables precise control of protein activity in living cells
11. NSERC awards $3 million for UdeM and Polytechnique training programs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/25/2017)... The Elements of Enterprise Information Security ... of a comprehensive set of business processes and ... identities and providing a secured and documented access ... number of programs opted by enterprises to maintain ... processes and changing policies. However, there are some ...
(Date:1/24/2017)... -- It sounds simple and harmless—an electronic sensor attached ... and alerts parents on their smart phones if, ... But pediatric experts argue that such devices may ... of medical benefits, especially to healthy babies. ... of healthy babies, promising peace of mind about ...
(Date:1/21/2017)... Research and Markets has announced the addition of the ... ... voice recognition biometrics market to grow at a CAGR of 19.36% ... present scenario and the growth prospects of the global voice recognition ... considers the revenue generated from the sales of voice recognition biometrics ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... ... 22, 2017 , ... LabRoots , the leading provider ... world, is pleased to announce the 2nd annual Precision Medicine Virtual Conference. The ... conference focused on the development and advancements in precision medicine. , Precision Medicine ...
(Date:2/22/2017)... ... 2017 , ... NDA Partners Chairman Carl Peck, MD ... in the FDA CDRH Division of Cardiovascular, Respiratory, and Neurological Devices and Medical ... Expert Consultant. , In Dr. Spyker’s accomplished career, he held positions as Senior ...
(Date:2/21/2017)... Feb. 21, 2017 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or the ... results for the three months ended December 31, 2016. ... life sciences and diagnostics company that develops and commercializes proprietary ... ... build on the commercial milestones achieved in fiscal 2016," said ...
(Date:2/21/2017)... (PRWEB) , ... February 21, 2017 , ... The medical ... for their use, in multiple areas of medicine, due to their differentiating characteristics. Stem ... and they have the ability to be induced to become tissue or organic-specific cells ...
Breaking Biology Technology: