Navigation Links
Technique to reattach teeth using stem cells developed at UIC
Date:9/29/2010

A new approach to anchor teeth back in the jaw using stem cells has been developed and successfully tested in the laboratory for the first time by researchers at the University of Illinois at Chicago.

The new strategy represents a potential major advance in the battle against gum disease, a serious infection that eventually leads to tooth loss. About 80 percent of U.S. adults suffer from gum disease, according to the National Institute of Dental and Craniofacial Research.

Researchers in UIC's Brodie Laboratory for Craniofacial Genetics used stem cells obtained from the periodontal ligament of molars extracted from mice, expanded them in an incubator, and then seeded them on barren rat molars. The stem cell-treated molars were reinserted into the tooth sockets of rats.

After two and four months, the stem cells aligned and formed new fibrous attachments between the tooth and bone, firmly attaching the replanted tooth into the animal's mouth, said Smit Dangaria, a bioengineering doctoral candidate who conducted the research. Tissue sections showed that the replanted tooth was surrounded by newly formed, functional periodontal ligament fibers and new cementum, the essential ingredients of a healthy tooth attachment.

In contrast, tooth molars that were replanted without new stem/progenitor cells were either lost or loosely attached and were resorbed, Dangaria said.

The study, published in an online issue of the journal Tissue Engineering, was funded through a grant by the National Institutes of Health.

Dangaria said the natural surface of the tooth played an essential role in the study.

"Our research uncovered the code required to reattach teeth -- a combination of natural tooth root surface structure together with periodontal progenitor cells," he said.

To verify that the ligament was formed by the transplanted stem cells and not by the animal's own cells, stem cells were labeled with green fluorescent protein prior to seeding them on the molars and re-inserting the teeth into the animal's mouth, Dangaria said.

According to Tom Diekwisch, director of the Brodie Laboratory, who is senior author on the paper, this is the first progenitor cell-based regeneration of a complete periodontal ligament in which a functional tooth was attached.

"Our strategy could be used for replanting teeth that were lost due to trauma or as a novel approach for tooth replacement using tooth-shaped replicas," said Diekwisch, who is also professor and head of oral biology.


'/>"/>

Contact: Sam Hostettler
samhos@uic.edu
312-355-2522
University of Illinois at Chicago
Source:Eurekalert

Related biology news :

1. New oil detection technique
2. New technique uncovers hidden insecticide resistance
3. Caltech chemists develop simple technique to visualize atomic-scale structures
4. NSF awards $10M to develop computing techniques for measuring and analyzing child behavior
5. Optical imaging technique for angioplasty
6. New tagging technique enhances view of living cells
7. Hips dont lie: Researchers find more accurate technique to determine sex of skeletal remains
8. New technique improves efficiency of biofuel production
9. Cheap, simple, noninvasive blood test may replace invasive diagnostic techniques in early pregnancy
10. Technique enables precise control of protein activity in living cells
11. NSERC awards $3 million for UdeM and Polytechnique training programs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2017)... 15 2017   ivWatch LLC , a medical device company ... today announced receipt of its ISO 13485 Certification, the global standard ... Organization for Standardization (ISO®). ... Model 400 Continuous Monitoring device for the early detection of IV ... "This is an important milestone for ...
(Date:6/23/2017)... ARMONK, N.Y. and ITHACA, N.Y. ... IBM ) and Cornell University, a leader in dairy ... combined with bioinformatics designed to help reduce the chances ... breaches. With the onset of this dairy project, Cornell ... the Consortium for Sequencing the Food Supply Chain, a ...
(Date:5/16/2017)...  Veratad Technologies, LLC ( www.veratad.com ), an innovative ... verification solutions, announced today they will participate as a ... thru May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions ... evolving digital world, defining identity is critical to nearly ...
Breaking Biology News(10 mins):
(Date:9/21/2017)... (PRWEB) , ... September 21, 2017 , ... ... scaffold technology, today announced the election of Paul Hermes, Entrepreneur in Residence at ... , Biorez has developed a proprietary, tissue-engineered scaffold for anterior cruciate ligament ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... Huron Digital Pathology , a provider of whole slide imaging solutions, are ... conference . The workshop, entitled “Successfully Deploying a Best-in-Class Strategy for Digital Pathology,” ...
(Date:9/19/2017)... Charleston, SC (PRWEB) , ... September 19, 2017 ... ... Express, safely and accurately automates the most dangerous step of sample prep for ... digestion system to provide automation at an affordable price. The system is ideal ...
(Date:9/19/2017)... Pleasanton, Calif. and Washington, D.C. (PRWEB) , ... ... ... to delivering rapid care during an biological outbreak is about to be eliminated, ... When asked what makes ExcitePCR’s FireflyDX™ technologies different than other pathogen ...
Breaking Biology Technology: