Navigation Links
Technique enables precise control of protein activity in living cells
Date:6/27/2010

ral Medical Sciences. "The capacity to precisely control the activity of this important class of proteins in living cells is a transformational advance in our ability to understand their roles in normal processes like cell growth and development, as well as their part in triggering diseases like cancer."

Hahn explains that the mechanism of engineered allosteric regulation can be compared to the wheels on a car. A small part of each kinase molecule is key to its action within the cell. Attaching a protein engineered by Andrei Karginov to this part of the kinase causes the molecule to vibrate, keeping it from working well enough to control the cell just as loose bolts on a car wheel will keep the vehicle from moving forward effectively.

Scientists then use a drug to bind the engineered protein, tightening up the molecule and allowing the kinase to work normally like tightening the bolts on a car wheel.

"It's very precise. Just as you can map which switch in the circuit box in your home controls specific lights and appliances, this mechanism controls specific kinases, allowing researchers to trace their action precisely within the cell," Hahn says.

Hahn predicts that the new technique will enable faster, less expensive study of cell signaling pathways implicated in cancer as well as a large range of human diseases and disorders.

Hahn points out that this was a highly collaborative effort, made possible only by combining the skills of UNC researchers from diverse disciplines. The research team from UNC includes molecular biologist Andrei V. Karginov, PhD, Research Assistant Professor of Pharmacology, and computational biologists Feng Ding, Research Assistant Professor of Pharmacology, Pradeep Kota, a graduate student in biochemistry and biophysics, and Nikolay V. Dokholyan, PhD, Associate Professor of Biochemistry and Biophysics.


'/>"/>

Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. NSERC awards $3 million for UdeM and Polytechnique training programs
2. New technique reliably detects enzyme implicated in cancer and atherosclerosis
3. TU Delft and MI Labs merge PET and SPECT biomedical imaging techniques and increase resolution
4. UT Southwestern researchers use novel sperm stem-cell technique to produce genetically modified rats
5. Technique yields potential biological substitute for dental implants
6. New technique enables drug tests via exhaled breath
7. Scientists use biomedical technique to image marine worm
8. UGA researchers use patented SERS technique to rapidly, accurately detect rotavirus strain
9. Creating new healthy ingredients by innovative milling techniques and processes for cereal grains
10. Faster Salmonella detection now possible with new technique
11. New microscopy technique reveals mechanics of blood cell membranes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... , December 9, 2014 ... ITN,s BCARD Platform   ... enterprise meeting scheduling solutions for business-to-business (B2B) events, ... world leader in mobile near-field communication (NFC), Bluetooth ...      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow ...
(Date:12/3/2014)... IRVINE, Calif. , Dec. 2, 2014 /PRNewswire/ ... of globally deployed, innovative test solutions for military, ... the newest version of its successful TS-900 ... the performance and features of high-end systems to ... with outstanding value compared to traditional ATE. ...
(Date:11/21/2014)... , Nov. 20, 2014 Strict laws against ... are piloting the North American and European automotive sector ... growing, gesture recognition systems that are intuitive and able ... in the industry. New analysis from ... Recognition Market in Europe and ...
Breaking Biology News(10 mins):Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4
... can often only be solved using forensics to piece ... Helmut Schmitz from the Institute of Zoology at the ... Peter Grnberg Institut at the Forschungzentrum Jlich went through ... beetles of the genus Melanophila and their ...
... This press release is available in ... I,m depressed and I,m depressed because I eat" in the ... research being undertaken by scientists affiliated with the University of ... Medicine. "In addition to causing obesity, rich foods can actually ...
... the selective force that preserves adaptive traits in organisms and ... well known that evolutionary change in organisms also trigger fundamental ... prime example of this evolutionary feedback loop in a few ... Colonial times trapped a fish called the alewife. ...
Cached Biology News:Forensics ferret out fire beetle secret 2Forensics ferret out fire beetle secret 3Scientists start explaining Fat Bastard's vicious cycle 2Not a 1-way street: Evolution shapes environment of Connecticut lakes 2
(Date:12/17/2014)... 2014 “Never say, ‘I cannot ... Marburg’s Department of Physics, advises young women pursuing ... released SPIE Women in Optics 18-month planner ... to ask questions.” , In the annual planner, ... occupations ranging from university professor and laboratory researcher ...
(Date:12/17/2014)... This report is a professional ... For an overview analysis, the report introduces quartz ... structure, industry overview, policy analysis, and news analysis, ... has witnessed rapid development with key manufacturers increasing ... report mentions quartz tubing upstream raw materials and ...
(Date:12/17/2014)... -- Vermillion, Inc. (NASDAQ: VRML ), a bio-analytic ... next step in its expanded strategy to rebuild the ... naming of current Chief Operating Officer, Valerie Palmieri ... Chairman of the Board and CEO James LaFrance ... are effective January 1, 2015. "Jim and ...
(Date:12/17/2014)... --  Synageva BioPharma Corp. (NASDAQ: GEVA ... disorders, announced today its presentation at the upcoming J.P. ... Francisco, CA. Sanj K. ... on Monday, January 12, 2015, at 9:00 a.m. PST ... and may be accessed from the "Webcasts & Presentations" ...
Breaking Biology Technology:Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 32020 Quartz Tubing Market: Global Development & Forecasts Analysis Now at DeepResearchReports.com 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 3Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 4
... MOUNTAIN VIEW, Calif., Dec. 4 Based on ... & Sullivan recognizes Honeywell Enraf with the 2008 ... Honeywell Enraf,s comprehensive suite of blending products facilitates ... and other materials, but also minimizes the end-products, ...
... of Life Technologies Corporation (NASDAQ:LIFE), a provider of ... announced that its technology for next-generation genomic analysis, ... Science Innovation of the Year for 2008 by ... the life science industry. In making the announcement ...
... an estimated ten percent of pregnant women in the U.S. ... cigarette byproducts from mothers who smoke affects an estimated 420,000 ... , Now, in the first study of its kind, a ... umbilical cord blood to better understand the fetal health risks ...
Cached Biology Technology:Frost & Sullivan Commends Honeywell Enraf for Cutting-Edge Products and Post-Sales Support 2Frost & Sullivan Commends Honeywell Enraf for Cutting-Edge Products and Post-Sales Support 3 Applied Biosystems SOLiD System Named Life Science Innovation of the Year : The Scientist Magazine Cites the Technology's High Throughput, Lower Sequencing Cost, and Rapid Technology Innovation for Unlocking New Approaches to Clinical Research 2 Applied Biosystems SOLiD System Named Life Science Innovation of the Year : The Scientist Magazine Cites the Technology's High Throughput, Lower Sequencing Cost, and Rapid Technology Innovation for Unlocking New Approaches to Clinical Research 3 Applied Biosystems SOLiD System Named Life Science Innovation of the Year : The Scientist Magazine Cites the Technology's High Throughput, Lower Sequencing Cost, and Rapid Technology Innovation for Unlocking New Approaches to Clinical Research 4 Applied Biosystems SOLiD System Named Life Science Innovation of the Year : The Scientist Magazine Cites the Technology's High Throughput, Lower Sequencing Cost, and Rapid Technology Innovation for Unlocking New Approaches to Clinical Research 5Cutting the cord to determine babies' health risk from toxic exposure 2Cutting the cord to determine babies' health risk from toxic exposure 3Cutting the cord to determine babies' health risk from toxic exposure 4
Rat Epidermal Keratinocytes (REK) (>500,000 cells)...
anti-Yan 8B12H9...
sPLA2-XII Human, Rabbit Polyconal Antibody Anti-Human sPLA2-XII Antibody was raised in rabbits against Human sPLA2-XII His-Tagged Fusion Protein Antigen: The recombinant human protein sPLA-XII...
... Expand the computing power of your ValveBank ... sequences with a PC computer running Windows 98, ... load unlimited programs to disk, print out program ... memory in one simple step., EasyCode is used ...
Biology Products: