Navigation Links
Technique enables precise control of protein activity in living cells
Date:6/27/2010

CHAPEL HILL, NC Cancer occurs when human cells move and multiply inappropriately. Within cells, a process called phosphorylation serves as an on/off switch for a number of cellular processes that can be involved in cancer, including metabolism, transcription, configuration, movement, cell death and differentiation. This process is controlled by a group of enzymes called protein kinases that working together and separately modify the structure of proteins, changing them and allowing them to control cellular processes.

One of the challenges to understanding the actions and interactions of kinases within cells has been that the mechanisms scientists used to control the enzymes were not specific, often affecting more than one pathway within the cell.

In a paper published today in the journal Nature Biotechnology, Klaus Hahn, PhD, who is the Thurman Professor of Pharmacology at the University of North Carolina at Chapel Hill and a member of UNC Lineberger Comprehensive Cancer Center, describes a new technique called engineered allosteric regulation, which provides a new tool for scientists who study the interactions of proteins within living cells.

"Engineered allosteric regulation is a new method that provides precise control of kinase activity in living cells," said Hahn.

"We can now take the kinase of choice and precisely control the 'on/off' switch, thereby seeing what they are doing and how they control cell function. The technology has exciting applications in basic research, since kinases are the central regulators of almost every cellular process. The ability to precisely control the state and timing of kinase action within cells opens the door to a broad range of new scientific insights," he added.

"This ingenious method offers a powerful new approach for dissecting the diverse functions of kinases in living cells," said James Deatherage, PhD, who oversees cell biology grants at the NIH's National Institute of Gene
'/>"/>

Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. NSERC awards $3 million for UdeM and Polytechnique training programs
2. New technique reliably detects enzyme implicated in cancer and atherosclerosis
3. TU Delft and MI Labs merge PET and SPECT biomedical imaging techniques and increase resolution
4. UT Southwestern researchers use novel sperm stem-cell technique to produce genetically modified rats
5. Technique yields potential biological substitute for dental implants
6. New technique enables drug tests via exhaled breath
7. Scientists use biomedical technique to image marine worm
8. UGA researchers use patented SERS technique to rapidly, accurately detect rotavirus strain
9. Creating new healthy ingredients by innovative milling techniques and processes for cereal grains
10. Faster Salmonella detection now possible with new technique
11. New microscopy technique reveals mechanics of blood cell membranes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/7/2014)... CORAL SPRINGS, Florida , November 6, 2014 ... improved secure authentication for better mobile security revolutionizing online transactions. ... NXTD ), Alibaba Holdings Ltd. (NYSE: BABA ), ... MSFT ), eBay Inc. (NASDAQ: EBAY ... (NASDAQ: NXTD and NXTDW), a biometric authentication ...
(Date:11/5/2014)... of biology in the UTSA College of Sciences, ... selected to receive a two-year $300,00 National Science ... (EAGER). The funding supports President Obama,s BRAIN Initiative, ... new technology that will demystify complex brain processes. ... neuroscience are broken into the interactions of multiple ...
(Date:11/4/2014)... – Temple University School of Medicine announced today ... an initiative funded by the Bill & Melinda ... of Obstetrics, Gynecology and Reproductive Sciences; and Vice ... University School of Medicine will pursue an innovative ... Blood Biomarkers to Assess Fetal Neurodevelopment.", Grand Challenges ...
Breaking Biology News(10 mins):Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3Temple University School of Medicine receives Grand Challenges Explorations grant 2
... at the University of Wisconsin-Madison may represent a significant ... that would use this abundant element to store and ... non-carbon, non-polluting fuel for storing intermittent energy from the ... water but no carbon dioxide. Practically speaking, producing hydrogen ...
... U.S. Department of Energy,s Brookhaven National Laboratory have identified ... human adenovirus, a cause of ailments ranging from colds ... in FEBS Letters , a journal of the ... sifted through thousands of compounds to determine which might ...
... have alteration in metabolic pathways as a result of ... 2-related factor 2) works as a "master gene" that ... pollutant-detoxifying genes to protect the lungs from variety of ... However, researchers at the Johns Hopkins Bloomberg School of ...
Cached Biology News:New catalyst could cut cost of making hydrogen fuel 2Scientists identify promising antiviral compounds 2Scientists identify promising antiviral compounds 3Hijacking stress response in cancer 2
(Date:11/26/2014)... 26, 2014 The Alliance for ... survey of European physicians at the "1 ST ... Biological Therapies" at the Spanish Ministry of Health, ... EuropaBio and the Spanish Bioindustry Association (ASEBIO), included ... from Spanish oncology and rheumatology societies, representatives from ...
(Date:11/26/2014)... PMG Research, Inc. announced today the formation of ... sites that provide clinical research services to pharmaceutical companies and ... its partnerships with large physician practices and integrated health systems. ... the Southeastern United States and spans over 60 physician practices. ... will be held by: Dr. Robert Holmes, MD, of PMG ...
(Date:11/26/2014)... 2014 Silicon Valley Electronic Data Capture ... RPM Alliance , provider of clinical research and data ... latest addition to its CRO Partnership Program, Clinovo expands ... to India. , “We have found Clinovo’s ClinCapture ... EDC platform which is both user friendly and easy ...
(Date:11/26/2014)... 25, 2014 Global biostimulants market ... growing at an estimated CAGR of 12.5%. In ... food products with least ecological impacts, farmers are ... to boost crop yield more effectively & efficiently. ... can improve the return on investments. , Leading ...
Breaking Biology Technology:ASBM Presents European Physicians Survey at Spanish Ministry of Health 2PMG Research Names Medical Advisory Board 2PMG Research Names Medical Advisory Board 3RPM Alliance Joins Clinovo’s CRO Partnership Program, Further Strengthening Its Presence in Southern California and India 22019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 22019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 32019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 4
... surgeons, MONTVALE, N.J., June 3 ... information dedicated to enhancing the surgeon,s,practice, has ... engine tool:,SURGERYFINDIT.COM ( http://www.SURGERYFINDIT.COM )., As ... provide,general surgeons with a wealth of peer-reviewed, ...
... June 3 National Stem Cell,Holding, Inc. (Pink ... Steiner, MD, MBA, as its Chief Operating Officer. ... proven management and business skills.,After establishing a private ... medical and business consultant to numerous Fortune 500 ...
... ANGELES, June 3 Signalife, Inc. (Amex:,SGN) has ... Ehrlichman -- who is,already a member of the ... Operating Officer. In that capacity, Mr. Ehrlichman,s primary ... will be on,sales and marketing of the company,s ...
Cached Biology Technology:SURGERYFINDIT.COM and Convera(R) Launch Vertical Search Site for Surgeons 2National Stem Cell Holding Appoints Kenneth Steiner, MD, MBA, as Chief Operating Officer 2National Stem Cell Holding Appoints Kenneth Steiner, MD, MBA, as Chief Operating Officer 3Signalife Appoints Lee Ehrlichman President and Chief Operating Officer 2Signalife Appoints Lee Ehrlichman President and Chief Operating Officer 3
...
X-Gal, 1 g. 5-Bromo-4-chloro-3-indolyl-b-d-galactoside.Histochemical substrate for b-galactosidase, used in blue/white screening.Store at -20 C. Protect from moisture. Category: Nucleotides & Enzymes...
Conjugation services for Antibodies, Proteins, Oligos, Peptides, Beads, bioconjugation, antibody-oligonucleotide, LNA peptide, LNA protein, LNA antibody, HRP, Alkaline phosphatase, phycoerythrin, FIT...
FGF Receptor 1 Antibody...
Biology Products: