Navigation Links
Technique enables precise control of protein activity in living cells
Date:6/27/2010

CHAPEL HILL, NC Cancer occurs when human cells move and multiply inappropriately. Within cells, a process called phosphorylation serves as an on/off switch for a number of cellular processes that can be involved in cancer, including metabolism, transcription, configuration, movement, cell death and differentiation. This process is controlled by a group of enzymes called protein kinases that working together and separately modify the structure of proteins, changing them and allowing them to control cellular processes.

One of the challenges to understanding the actions and interactions of kinases within cells has been that the mechanisms scientists used to control the enzymes were not specific, often affecting more than one pathway within the cell.

In a paper published today in the journal Nature Biotechnology, Klaus Hahn, PhD, who is the Thurman Professor of Pharmacology at the University of North Carolina at Chapel Hill and a member of UNC Lineberger Comprehensive Cancer Center, describes a new technique called engineered allosteric regulation, which provides a new tool for scientists who study the interactions of proteins within living cells.

"Engineered allosteric regulation is a new method that provides precise control of kinase activity in living cells," said Hahn.

"We can now take the kinase of choice and precisely control the 'on/off' switch, thereby seeing what they are doing and how they control cell function. The technology has exciting applications in basic research, since kinases are the central regulators of almost every cellular process. The ability to precisely control the state and timing of kinase action within cells opens the door to a broad range of new scientific insights," he added.

"This ingenious method offers a powerful new approach for dissecting the diverse functions of kinases in living cells," said James Deatherage, PhD, who oversees cell biology grants at the NIH's National Institute of Gene
'/>"/>

Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. NSERC awards $3 million for UdeM and Polytechnique training programs
2. New technique reliably detects enzyme implicated in cancer and atherosclerosis
3. TU Delft and MI Labs merge PET and SPECT biomedical imaging techniques and increase resolution
4. UT Southwestern researchers use novel sperm stem-cell technique to produce genetically modified rats
5. Technique yields potential biological substitute for dental implants
6. New technique enables drug tests via exhaled breath
7. Scientists use biomedical technique to image marine worm
8. UGA researchers use patented SERS technique to rapidly, accurately detect rotavirus strain
9. Creating new healthy ingredients by innovative milling techniques and processes for cereal grains
10. Faster Salmonella detection now possible with new technique
11. New microscopy technique reveals mechanics of blood cell membranes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... , Mar. 24, 2015 Research and Markets ... the "Global Iris Recognition Market 2015-2019" report ... Global Iris Recognition market to grow at a CAGR ... This report covers the present scenario and the growth ... period 2015-2019. To calculate the market size, the report ...
(Date:3/24/2015)... Fla. , March 24, 2015   ... management solutions, today announced that its U.are.U ® ... accessory retailer Goorin Bros . to achieve ... biometrics-based solution secures access to the POS terminal, ... increased risk of data breaches. ...
(Date:3/23/2015)... , March 23, 2015  In the 2014 fiscal ... case conviction losses. This figure accounts for a fraction ... to The Nilson Report, exceeds $11 billion globally. The ... after a crime has occurred. Investor Mark Saint ... expert Joe Paolella partnered to administer the ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... Levanger, Norway and Boulder, CO, USA -- April 10, ... a new collaboration to advance the clinical use of ... of biomarkers for the prediction of cardiovascular events such ... collaboration will analyze biological samples and clinical data from ...
... N.M. An air sampler the size of an ear ... to improve computer climate models. "We now have an ... said Sandia National Laboratories researcher Ron Manginell, lead author of ... , the often-cited journal of the American Institute of Physics. ...
... Alzheimer,s disease (AD) is now the sixth leading cause of death ... of 65. There is currently no treatment that alters the course ... changes in the way the body handles iron and other metals ... AD symptoms. A new study shows that reducing iron levels in ...
Cached Biology News:Miniature Sandia sensors may advance climate studies 2Miniature Sandia sensors may advance climate studies 3Miniature Sandia sensors may advance climate studies 4Miniature Sandia sensors may advance climate studies 5Antioxidant may disrupt Alzheimer's disease process 2
(Date:3/31/2015)... 31, 2015 CytoSorbents Corporation (NASDAQ CM: ... purification to treat critically-ill and cardiac surgery patients ... and reports financial results for the fiscal year ... CytoSorb® product revenues were a record $3.1M, an ... CytoSorb® revenues of $0.8M Highlights for the Year ...
(Date:3/31/2015)... Pittcon 2015, the 66th Conference and Exposition ... 12, in New Orleans with an economic impact to ... the New Orleans Convention and Visitor's Bureau. This global ... personnel. Those who attended Pittcon for the first-time ... third year, the co-location of Food Labs Conference, organized ...
(Date:3/31/2015)... and NEW YORK ... (NASDAQ: PTBI ), a biopharmaceutical company advancing ... announced today that its Korean marketing partner, Hanmi ... marketing approval in Korea from the country,s Ministry ... Korea Testing & Research Institute (KTR) for MuGard, ...
(Date:3/31/2015)... Lighthouse Information Systems, Inc., a West ... Oregon, Washington and clients across the US, announces ... (M&A) Integration Services offering, effective immediately. ... M&A Integration Practice Leader at Lighthouse, explains, “Research ... M&A initiatives fail to achieve their intended economic ...
Breaking Biology Technology:CytoSorbents Reports Record 2014 Revenue 2CytoSorbents Reports Record 2014 Revenue 3CytoSorbents Reports Record 2014 Revenue 4CytoSorbents Reports Record 2014 Revenue 5CytoSorbents Reports Record 2014 Revenue 6CytoSorbents Reports Record 2014 Revenue 7CytoSorbents Reports Record 2014 Revenue 8CytoSorbents Reports Record 2014 Revenue 9CytoSorbents Reports Record 2014 Revenue 10CytoSorbents Reports Record 2014 Revenue 11Pittcon 2015 Hits the Big Easy in a Big Way 2Pittcon 2015 Hits the Big Easy in a Big Way 3Pittcon 2015 Hits the Big Easy in a Big Way 4PlasmaTech Biopharmaceuticals' Partner Hanmi Pharmaceuticals Receives Marketing Approval For MuGard In Korea 2PlasmaTech Biopharmaceuticals' Partner Hanmi Pharmaceuticals Receives Marketing Approval For MuGard In Korea 3Lighthouse Information Systems, Inc., Announces Addition of M&A Integration Services 2
... A. How is fold amplification , ... using the Van Gelder and Eberwine ... an oligo(dT) primer containing the T7 RNA polymerase , ... at the end of mRNA sequences serves as the substrate for the , ...
... , Quantitate gene ... 5 minute cell lysis , ... monitoring , siRNA-induced knockdown , ... Gene Expression Assays and SYBR Green , ...
... , , ... and validation Screening for miRNAs that regulate target , ... cellular process , ... RNAs that are expressed in animals and plants and affect the , ...
Cached Biology Technology:RNA Amplification for Array Analysis 2RNA Amplification for Array Analysis 3RNA Amplification for Array Analysis 4Ready for Real-time in 5 Minutes 2Ready for Real-time in 5 Minutes 3Ready for Real-time in 5 Minutes 4Ready for Real-time in 5 Minutes 5Ready for Real-time in 5 Minutes 6Precursor miRNAs for Successful miRNA Functional Studies 2Precursor miRNAs for Successful miRNA Functional Studies 3Precursor miRNAs for Successful miRNA Functional Studies 4Precursor miRNAs for Successful miRNA Functional Studies 5Precursor miRNAs for Successful miRNA Functional Studies 6Precursor miRNAs for Successful miRNA Functional Studies 7Precursor miRNAs for Successful miRNA Functional Studies 8Precursor miRNAs for Successful miRNA Functional Studies 9Precursor miRNAs for Successful miRNA Functional Studies 10Precursor miRNAs for Successful miRNA Functional Studies 11
Request Info...
These macrocarriers are for the biolistic PDS-1000 He and Hepta systems. Supplied as 500 macrocarriers....
... [pTyr 209/ pSer 211 ] affinity isolated ... Dulbecco's phosphate buffered saline (without Mg 2+ ... mg/ml BSA (IgG and protease free) and 0.05% ... the region of mouse Hck that contains tyrosine ...
High voltage electrophoresis power supply...
Biology Products: