Navigation Links
Team uses antisense technology that exploits gene splicing mechanism to kill cancer cells
Date:10/31/2012

Cold Spring Harbor, N.Y. Cancer cells grow fast. That's an essential characteristic of what makes them cancer cells. They've crashed through all the cell-cycle checkpoints and are continuously growing and dividing, far outstripping our normal cells. To do this they need to speed up their metabolism.

CSHL Professor Adrian Krainer and his team have found a way to target the cancer cell metabolic process and in the process specifically kill cancer cells.

Nearly 90 years ago the German chemist and Nobel laureate Otto Warburg proposed that cancer's prime cause was a change in cell metabolism i.e., in cells' production and consumption of energy. In particular cancer cells have a stubborn propensity to eschew using glucose as a source to generate energy. This is known as the Warburg Effect.

While metabolic changes are an important feature in the transformation of normal cells into cancer cells they are not now thought to be cancer's primary cause. Despite this, metabolic changes remain an attractive target for cancer therapy, as Krainer and colleagues show in a paper published online today in Open Biology, the open-access journal of Great Britain's Royal Society.

One difference between metabolism in cancer and normal cells is the switch in cancer to the production of a different version, or isoform, of a protein produced from the pyruvate kinase-M (PK-M) gene. The protein version produced in normal cells is known as PK-M1, while the one produced by cancer cells is known as PK-M2.

PK-M2 is highly expressed in a broad range of cancer cells. It enables the cancer cell to consume far more glucose than normal, while using little of it for energy. Instead, the rest is used to make more material with which to build more cancer cells.

PK-M1 and PK-M2 are produced in a mutually exclusive manner -- one-at-a-time, from the same gene, by a mechanism known as alternative splicing. When a gene's DNA is being copied i
'/>"/>

Contact: Edward Brydon Ph.D.
ebrydon@cshl.edu
917-476-6633
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Labor der Zukunft -- Tomorrows laboratory technology
2. The future of plant science - a technology perspective
3. The future of plant science a technology perspective
4. Ultracold matter technology from CU and SRI International licensed to Boulders ColdQuanta
5. UF researchers look for ways to make an emerging technology safe for environment
6. Breast cancer risk gene discovery fast tracked by new technology
7. Obese patients face higher radiation exposure from CT scans -- but new technology can help
8. NYU School of Medicine presents 2012 Dart/NYU Biotechnology Achievement Awards
9. Powerful sequencing technology decodes DNA folding pattern
10. New technology tracks sparrow migration for first time from California to Alaska
11. M2SYS Technology Partners with Hitachi to Offer Innovative Biometric Finger Vein Scanner to US Market
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... 2015 La 10e Conférence internationale sur ... par le BGI du 22 au 25 octobre ... Chine. La conférence célèbre son 10e ... l,ICG est devenue l,une des réunions annuelles mondiales ... et c,est aussi la plus dynamique, la plus ...
(Date:7/31/2015)... , Jul. 31, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market and ... has filed provisional patent 62/198989 for ELECTRONIC ... highlights a method to advance crypto-currencies such as Bitcoin ... a common, uniform way to manage all payments.  ...
(Date:7/27/2015)... 27, 2015  Synaptics Inc. (NASDAQ: SYNA ... today announced that Huawei has selected the Synaptics ... its stylish smartwatch. Huawei chose the state-of-the-art ClearPad ... power and highly responsive human interface qualities such ... also required a classic round watch face and ...
Breaking Biology News(10 mins):La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3
... livelihoods and ecotourism industries can benefit from having a ... reefs, marine researchers say. Despite their small size, ... get more attention, herbivorous fish play a vital role ... the livelihoods of 500 million people worldwide, say researchers ...
... German . The Rubicon was crossed, ... (CFN) and at the Institute of Applied Physics (AP) in ... acoustics ideas, for example inaudibility cloaks, acoustic prisms or new ... So far, pentamodes, proposed in 1995 by ...
... Calif.) Since 2009, a free Web-based marine mapping ... scientists has proved to be an essential tool for ... the next-generation tool is going global. Thanks to ... founder of Esri, the world,s largest geographic information systems ...
Cached Biology News:Weed-eating fish 'help protect jobs, livelihoods' 2Weed-eating fish 'help protect jobs, livelihoods' 3KIT researchers succeed in realizing a new material class 2SeaSketch, the next generation of UCSB's MarineMap program, will aid marine spatial planning 2SeaSketch, the next generation of UCSB's MarineMap program, will aid marine spatial planning 3
(Date:8/26/2015)... After litigating and negotiating patent infringement claims brought ... United States patent RE43,651 (the ,651 patent), ... United States without any admission or concession of ... a result of the parties, settlement, the US District Court ... dismissed the case without prejudice. Under the terms ...
(Date:8/26/2015)... ... , ... PRC Clinical, a Clinical Trial Management Expert CRO, will ... southern California. The Clinical Trial Management Expert CRO seeks to introduce more California-based sponsors ... , Stem Cell Meeting on the Mesa on October 7-9 ...
(Date:8/25/2015)... Aug. 25, 2015   WuXi PharmaTech (Cayman) Inc. ... and technology platform company serving the pharmaceutical, biotechnology, and ... Pharm," Hong Kong Exchange Stock Code: 0950), a research-based ... with 20 years of operations in ... have signed an agreement whereby WuXi,s Laboratory Testing Division ...
(Date:8/25/2015)... ... August 25, 2015 , ... Vets Plus, Inc. ... Wis. The company has added a AS16 Sharples centrifuge to harvest products after ... bacterial or fungal fermentation process development. , The new centrifuge greatly expands ...
Breaking Biology Technology:P2i Settles United States Litigation 2PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 2PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 3WuXi PharmaTech to Be Exclusive Supplier of Laboratory Testing Services to Lee's Pharm 2WuXi PharmaTech to Be Exclusive Supplier of Laboratory Testing Services to Lee's Pharm 3New centrifuge and fermentor expand product development capacity at Vets Plus 2
... I am familiar with bad jobs. , ,My youngest brother ... involved wandering through unfamiliar neighborhoods, worrying about making a daily ... a shared apartment. After a few weeks of this, my ... brother once found a job selling environmentally friendly household products, ...
... the seed capital he needs to fuel his rapidly growing ... are legally allowed to make angel investments. , ,This is ... Wisconsins tech community, Peter M. Skanavis is doing everything he ... angel investments to actually take the plunge and put their ...
... stories coming out of California, but the failure of flight ... one of the weirdest. , ,The radio system used by ... a snit when its regular monthly maintenance wasnt performed and ... but couldnt talk to them, even as the planes converged ...
Cached Biology Technology:Beware the cold-call job interview 2Beware the cold-call job interview 3Beware the cold-call job interview 4Beware the cold-call job interview 5Investor profile: Peter M. Skanavis, tech angel, sees investing as civic duty 2Investor profile: Peter M. Skanavis, tech angel, sees investing as civic duty 3Investor profile: Peter M. Skanavis, tech angel, sees investing as civic duty 4Proactive nightmares 2
... Satellite Thermal Cycler (MBS) is ... for medium to high throughput ... the latest in satellite block ... PC control, resulting in a ...
45° Fixed Angle Rotor for use in the IEC Centra CL2, Centra CL3/CL3R, HN-SII, and the Centra-MP4/MP4R....
Glycerokinase; from Bacillus stearothermophilus...
...
Biology Products: