Navigation Links
Team solves decades-old molecular mystery linked to blood clotting
Date:5/31/2011

ogether during membrane binding of coagulation factors. But these predictions had to be tested experimentally."

Rienstra's lab then analyzed the samples using SSNMR, a technique that allows researchers to precisely measure the distances and angles between individual atoms in large molecules or groups of interacting molecules. His group found that one of every six or seven PS molecules was binding directly to the clotting factor, providing strong experimental support for the model derived from the simulations.

"That turned out to be a key insight that we contributed to this study," Rienstra said.

The team reasoned that if the PE head-groups were simply bending out of the way, then any phospholipid with a sufficiently small head-group should work as well as PE in the presence of PS. This also explained why only one PS molecule was actually binding to a GLA domain. The other phospholipids nearby were also interacting with the clotting factor, but more weakly.

The finding explained another mystery that had long daunted researchers. A different type of membrane lipid, phosphatidylcholine (PC), which has a very large head-group and is most abundant on the outer surface of cells, was known to block any association between the membrane and the clotting factor, even in the presence of PS.

Follow-up experiments showed that any phospholipid but PC enhanced the binding of PS to the GLA domain. This led to the "ABC" hypothesis: when PS is present, the GLA domain will interact with "Anything But Choline."

"This is the first real insight at an atomic level of how most of the blood-clotting proteins interact with membranes, an interaction that's known to be essential to blood clotting," Morrissey said. The findings offer new targets for the development of drugs to regulate blood clotting, he said.


'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Of mice and men: UNC-led team solves mouse genome dilemma
2. Mystery dissolves with calcium pump discovery
3. A collaboration solves the herpes virus protein structure providing new drug therapy directions
4. Brown biologist solves mystery of tropical grasses origin
5. Genetic sleuth solves glaucoma mystery
6. Scripps research team solves structure of beneficial virus
7. Cold cases gone hot: Montreal researchers solve decades-old medical mysteries using genetics
8. UC San Diego engineer provides insights to decades-old DNA squabble
9. Molecular technique advances soybean rust resistance research
10. Several baffling puzzles in protein molecular structure solved with new method
11. Molecular movements of neural transporters unveiled
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Team solves decades-old molecular mystery linked to blood clotting
(Date:1/22/2015)... , Jan. 9, 2015 Valid S.A. ("Company") (BM&FBOVESPA: VLID3 ... in general the State of Washington,s ... a new enrollment and central issuance system for driver,s licenses ... The project planning and development will start in January ...
(Date:1/22/2015)... 13, 2015 Technology Showcase, Hall E -   EyeLock ... today announced it will showcase its EyeLock ID technology integrated ... Department of Energy,s Oak Ridge National Laboratory (ORNL) ... EyeLock,s iris identity authentication technology is being used to validate ...
(Date:1/22/2015)... 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) ... on the recent success of the Wocket™ smart wallet at CES 2015 ... wallet was named as one of the "11 Hot Products at CES" ... Launched At CES So Far" by Newseveryday.com and "The top 10 gadgets ...
Breaking Biology News(10 mins):Valid USA Signs Contract For Washington Driver's License Issuance 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3
... is banned can have benefits that extend beyond the ... to new evidence from Australia,s Great Barrier Reef reported ... , a Cell Press publication. Researchers have found that ... ), which can devastate coral reefs, occur less often ...
... a new imaging system that allows them to see ... work, which could help scientists understand how precancerous mutations ... to pinpoint the number and location of mutant cellscells ... the researchers worked with mouse pancreatic cells. "Understanding ...
... infected with a second strain of the virus, the ... third, recombinant strain of the virus. It is ... superinfection, frequently leads to a loss of immune control ... Partners AIDS Research Center at Massachusetts General Hospital (PARC/MGH) ...
Cached Biology News:Fishing ban guards coral reefs against predatory starfish outbreaks 2MIT researchers offer glimpse of rare mutant cells 2Viral recombination another way HIV fools the immune system 2
(Date:1/22/2015)... Diego, California (PRWEB) January 22, 2015 ... Promotional Offer to their comprehensive portfolio of Eppendorf ... allows customers to purchase a Centrifuge 5424/5424 R and ... Bundle of either Eppendorf Research plus or Eppendorf Reference ...
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently was invited to ... on probiotics in San Diego, CA. , The Scripps ... health care professionals. This year’s pre-conference seminar was held on ... Dr. Leyer spoke about the emerging topics and science in ...
(Date:1/22/2015)... 22, 2015 Selexis SA, a serial ... Cell Banks (RCBs) used for drug discovery to commercial ... will include Next-Generation Sequencing (NGS) data packages. ... biologic manufacturing by ensuring the integrity of the gene, ...
(Date:1/22/2015)... , 22 de enero de 2015  El Dr. ... su llamada a nominaciones para 2015. Este prestigioso premio ... o tiene el potencial para hacer, contribuciones destacadas para ... aceptarán hasta el 15 de marzo de 2015 a ...
Breaking Biology Technology:Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4
... 1, 2008 Piedmont Heart Institute (PHI),expands its ... practice, Cardiology of Georgia, P.C. (COG), through a ... With eight,locations including Buckhead, Canton, Fayetteville and North ... the Piedmont Heart Institute and an,important addition to ...
... and System Data into the Cisco Open Platform for ... Agencies to Protect ... Assets, Employees, and Citizens, MORGANTOWN, W.Va., April ... technologies, today announced it,has partnered with Cisco on the newly ...
... Dr. Roger Kenneth,Hershline, PhD, MD, the CEO of ... public charity CureHIV.us, announces today,that he is reaching out ... Grand Challenges in Global Health initiative. The,monies would be ... and treatment,method, LiSAVIOR., This unique new drug is ...
Cached Biology Technology:Piedmont Heart Institute Welcomes Cardiology of Georgia 2Piedmont Heart Institute Welcomes Cardiology of Georgia 3Piedmont Heart Institute Welcomes Cardiology of Georgia 4Augusta Systems Technologies Integrated into Cisco's Newly Launched Safety and Security Platform 2Augusta Systems Technologies Integrated into Cisco's Newly Launched Safety and Security Platform 3Cure HIV Reaches Out to Foundation Community to Fund LiSAVIOR 2
PTC-100 cycler with gold/silver block with Hot Bonnet heated lid, holds one 96-well V-plate or96x0.2ml tubes...
... The DTX Series Multimode Detectors provide ... variety of application and automation needs. ... absorbance measurements on the same instrument, ... standalone instruments or can be integrated ...
... Deparaffinization Solution is available in a ... easy-to-use reagent for dewaxing paraffin-embedded tissue ... situ hybridization, or other analytical methods. ... consists of dipping the slides in ...
... Mini thermal cycler is a compact instrument for ... ml tubes, 12 x 0.5 ml tubes, or ... uses a thumbwheel to adjust height and pressure ... Peltier heat pumps provide excellent thermal performance, and ...
Biology Products: