Navigation Links
Team solves decades-old molecular mystery linked to blood clotting
Date:5/31/2011

CHAMPAIGN, lll. Blood clotting is a complicated business, particularly for those trying to understand how the body responds to injury. In a new study, researchers report that they are the first to describe in atomic detail a chemical interaction that is vital to blood clotting. This interaction between a clotting factor and a cell membrane has baffled scientists for decades.

The study appears online in the Journal of Biological Chemistry.

"For decades, people have known that blood-clotting proteins have to bind to a cell membrane in order for the clotting reaction to happen," said University of Illinois biochemistry professor James Morrissey, who led the study with chemistry professor Chad Rienstra and biochemistry, biophysics and pharmacology professor Emad Tajkhorshid. "If you take clotting factors off the membrane, they're thousands of times less active."

The researchers combined laboratory detective work with supercomputer simulations and solid-state nuclear magnetic resonance (SSNMR) to get at the problem from every angle. They also made use of tiny rafts of lipid membranes called nanodiscs, using an approach developed at Illinois by biochemistry professor Stephen Sligar.

Previous studies had shown that each clotting factor contains a region, called the GLA domain, which interacts with specific lipids in cell membranes to start the cascade of chemical reactions that drive blood clotting.

One study, published in 2003 in the journal Nature Structural Biology, indicated that the GLA domain binds to a special phospholipid, phosphatidylserine (PS), which is embedded in the membrane. Other studies had shown that PS binds weakly to the clotting factor o
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related biology news :

1. Of mice and men: UNC-led team solves mouse genome dilemma
2. Mystery dissolves with calcium pump discovery
3. A collaboration solves the herpes virus protein structure providing new drug therapy directions
4. Brown biologist solves mystery of tropical grasses origin
5. Genetic sleuth solves glaucoma mystery
6. Scripps research team solves structure of beneficial virus
7. Cold cases gone hot: Montreal researchers solve decades-old medical mysteries using genetics
8. UC San Diego engineer provides insights to decades-old DNA squabble
9. Molecular technique advances soybean rust resistance research
10. Several baffling puzzles in protein molecular structure solved with new method
11. Molecular movements of neural transporters unveiled
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Team solves decades-old molecular mystery linked to blood clotting
(Date:5/16/2013)... 16, 2013 The relationship between the heritable ... not been clear. Schizophrenia is commonly associated with ... are clues that reduced IQ may be linked ... reduced cognitive ability may precede the onset of ... in healthy relatives of people diagnosed with schizophrenia. ...
(Date:5/16/2013)... that are about 23 million years old give ... gobioid order, one of the most species-rich groups ... by paleontologist Professor Bettina Reichenbacher from the Division ... Earth and Environmental Sciences at Ludwig-Maximilians-Universitaet (LMU) in ... of fish fossils which they assign to the ...
(Date:5/16/2013)... in Cameroon and the manager of San Diego Zoo ... prestigious Whitley award. The Whitley award is an ... because it celebrates the extraordinary achievements of some of ... Abwe was selected for the award due to his ... and its wildlife inhabitants., HRH The Princess Royal, the ...
Breaking Biology News(10 mins):Genetic risk for schizophrenia is connected to reduced IQ 2Paleontology: The eloquence of the otoliths 2Paleontology: The eloquence of the otoliths 3Cameroon researcher wins prestigious 'Green Oscar' 2Cameroon researcher wins prestigious 'Green Oscar' 3
... is drawn tighter as a new research published online ... study shows that what your mother ate when she ... altering the function of genes (epigenetic changes) that regulate ... a high-fat diet altered the function of fetal genes ...
... This October more than 60 guides and anglers in the ... the Marquesas, assisting in the annual bonefish census. This year,s ... down by 25-percent from an 8-year mean estimate of 316,805 ... to Professor Jerry Ault, a fisheries scientist with the University ...
... resonance imaging (MRI), a medical imaging technology used to image ... the efficiency of jet engines, according to Lt. Colonel Michael ... In only a few hours, an MRI collects ... methods that take two or more years of intensive measurement. ...
Cached Biology News:New sleep cycle discovery explains why fatty diets during pregnancy make kids obese 2Fall bonefish census sounds warning bell that warrants careful future monitoring 2Jet engine too hot? Schedule an MRI! 2Jet engine too hot? Schedule an MRI! 3
(Date:5/17/2013)... 2013 Rust removal is one of home ... items could be damaged. To help rust contractors make it ... no-scrubbing rust remover it called Rusterizer. It announced ... 10% discount. , My Cleaning Products explained that rust could ... by staining them. The first one, it said, happens ...
(Date:5/16/2013)... ISPE announced today ... to the newly created position of Vice President ... will be responsible for stimulating ISPE’s revenue growth ... the Society’s Member-led and staff-driven business model, initiating ... organizational, membership and product marketing. , “Barbara joins ...
(Date:5/16/2013)... Cambridge Healthtech Institute will host its ... at the Renaissance Waterfront Hotel in Boston, MA. ... look at the current strategies and innovations for optimizing ... Leaders in the field will reveal how their work ... greater specificity and efficiency. , “In this age of ...
(Date:5/16/2013)... -- Scientists at the Center for Learning and Memory, ... California -based biopharmaceutical company Magceutics, Inc. ... reversing memory decline in mice with Alzheimer,s Disease. By ... in advanced stage AD mice. The study is the ... for advanced stage AD mice, and is also the ...
Breaking Biology Technology:Organic-Based Rust Remover Cuts Down Price by 10%, My Cleaning Products Details Mechanics How to Get the Discount 2ISPE Names Barbara A. Myers, CAE, as Vice President of Professional Development 2The 2013 Bioprocessing Summit to Bring Together International Leaders to Discuss Today's Bioprocess Issues From Cell Line Selection to Manufacturing in Boston, MA 2Elevation of Brain Magnesium Reverses Memory Deficits in Alzheimer Mice 2Elevation of Brain Magnesium Reverses Memory Deficits in Alzheimer Mice 3
... March 11, 2011 Apexigen, Inc., an emerging biopharmaceutical ... announced today that its partner, Simcere Pharmaceutical Group (NYSE: ... China, filed an Investigational New Drug (IND) application with ... to evaluate APX003 (also known as BD0801) as a ...
... dreaming of mobile devices that run longer on lighter, ... granted. University of Illinois engineers have developed a ... uses 100 times less energy than similar available memory. ... battery life between charges. Led by electrical and ...
... Technology, Inc. (“ACT”; OTC Bulletin Board: ACTC ... announced today that the Committee for Orphan Medicinal Products ... a positive opinion of ACT,s human embryonic stem cell ... an orphan medicinal product for the treatment of Stargardt,s ...
Cached Biology Technology:Apexigen Announces the Filing by its Partner, Simcere Pharmaceutical Group, of First IND 2New technology would dramatically extend battery life for mobile devices 2New technology would dramatically extend battery life for mobile devices 3ACT Receives Positive Opinion for Orphan Drug Designation from European Medicines Agency for hESC-Derived RPE Cells for Treatment of Stargardt's Disease 2ACT Receives Positive Opinion for Orphan Drug Designation from European Medicines Agency for hESC-Derived RPE Cells for Treatment of Stargardt's Disease 3
Mouse HAI-1 Ectodomain MAb (Clone 199732)...
pETDuet-1 is designed for the coexpression of two target genes....
Human IL-29/IFN-lambda 1 Biotinylated Affinity Purified PAb...
Mouse Laminin-1 MAb (Clone AL-3)...
Biology Products: