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Team receives $22.5 million to shed light on the immune system
Date:8/23/2012

y's first line of defense, can destroy foreign invaders and trigger inflammation that contributes to their demise. If microorganisms make it past this gauntlet, the body calls on adaptive immunity. Here, T cells, B cells, antibodies, and killer cells come into play; the adaptive immune system also stores "memories" of the offending microorganisms to be on the alert for future attacks.

The team is using a genetic approach in mice, known as "forward genetics," to develop a detailed model of innate and adaptive immune responses to infection. "It is now crystal clear that data from mouse genetics provides insights into human disease," Ulevitch said. "When we started there were a lot more unknowns, but now there is a long list of genes identified in the mouse that cause both specific mouse phenotypes and are similarly linked to human disease."


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Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

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