Navigation Links
Team receives $22.5 million to shed light on the immune system
Date:8/23/2012

LA JOLLA, CA, August 23, 2012 A team led by a scientist at The Scripps Research Institute has received a $22.5 million, five-year project renewal from the National Institutes of Health to uncover the workings of the immune system. This program has received ongoing support from NIH since 2002.

The grant is focused on innovative technologies that will ultimately provide data for improving a wide range of human diseases that include viral and bacterial infections and inherited immune disorders.

"I'm delighted the National Institute of Allergy and Infectious Diseases has decided to continue supporting this important research," said the grant's principal investigator Richard Ulevitch, who is a professor and chairman emeritus at Scripps Research. "Since the initiative began 10 years ago, the consortium has made seminal contributions to the field. Now, thanks to the new funding, there are more discoveries to come."

The project takes an unusual wide-angle "genetic and systems biology" approach to learning how we stay healthy in the face of numerous microbes in our environment. In contrast to traditional hypothesis-driven research, in which a single gene or protein is selected for study based on its proposed function, team members assemble information about multiple genes, proteins, and biochemical pathways without preconceived ideas about function. This data is then integrated and examined from multiple perspectives to understand the immune response as a whole.

In addition to Ulevitch and his group at Scripps Research, the consortium includes the laboratories of Alan Aderem of the Seattle Biomedical Research Institute, Bruce Beutler of University of Texas Southwestern Medical Center, Christopher Goodnow of the Australian National University, and Garry Nolan of Stanford University.

Ulevitch notes that the group is now especially interested in the intersection between innate and adaptive immunity. Innate immunity, our body's first line of defense, can destroy foreign invaders and trigger inflammation that contributes to their demise. If microorganisms make it past this gauntlet, the body calls on adaptive immunity. Here, T cells, B cells, antibodies, and killer cells come into play; the adaptive immune system also stores "memories" of the offending microorganisms to be on the alert for future attacks.

The team is using a genetic approach in mice, known as "forward genetics," to develop a detailed model of innate and adaptive immune responses to infection. "It is now crystal clear that data from mouse genetics provides insights into human disease," Ulevitch said. "When we started there were a lot more unknowns, but now there is a long list of genes identified in the mouse that cause both specific mouse phenotypes and are similarly linked to human disease."


'/>"/>
Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Related biology news :

1. University of Minnesota receives $13.1 million in DOE funding for 2 new nationwide centers
2. WPI receives $1.9 million from US Army to develop sensors that can save wounded soldiers
3. Clemson scholar receives top agriculture science award
4. The Johns Hopkins Center for Inherited Disease Research receives $101 million
5. Ben-Gurion University of the Negev receives $450,000 grant to conduct oil and natural gas research
6. Rutgers-Camden genetics researcher receives NSF CAREER Award
7. Salk Professor Terrence Sejnowski receives IEEE Frank Rosenblatt Award
8. IU biologist receives Department of Energys top young faculty award
9. Wyss Institute receives up to $37 million from DARPA to integrate organ chips to mimic the human body
10. China Botanic Receives Patent on its Schisandra Lignin Extraction Method
11. NASA Goddard scientist receives Presidential Early Career Award
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Team receives $22.5 million to shed light on the immune system
(Date:6/9/2016)... attendance control systems is proud to announce the introduction of fingerprint attendance control software, ... employees are actually signing in, and to even control the opening of doors. ... ... ... Photo - http://photos.prnewswire.com/prnh/20160609/377487 ...
(Date:6/3/2016)... 3, 2016 Das ... Nepal hat ein 44 ... geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, ... Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte ... Januar teilgenommen, aber Decatur wurde als konformste ...
(Date:6/2/2016)... June 2, 2016 Perimeter Surveillance ... Unmanned Systems, Physical Infrastructure, Support & Other Service  ... visiongain offers comprehensive analysis of the global ... will generate revenues of $17.98 billion in 2016. ... Inc, a leader in software and hardware technologies for ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Apellis ... Phase 1 clinical trials of its complement C3 ... single and multiple ascending dose studies designed to ... (PD) of subcutaneous injection in healthy adult volunteers. ... (SC) either as a single dose (ranging from ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory Compliance ... consulting, provides a free webinar on Performing Quality Investigations: Getting to ... 12pm CT at no charge. , Incomplete investigations are still a major concern ...
(Date:6/22/2016)... 22, 2016 Research and Markets has announced ... report to their offering. ... from $29.3 billion in 2013. The market is expected to grow ... 2015 to 2020, increasing from $50.6 billion in 2015 to $96.6 ... during the forecast period (2015 to 2020) are discussed. As well, ...
(Date:6/22/2016)... Washington, USA (PRWEB) , ... June 21, 2016 , ... ... and without cutting into the tissue — promise to enable both compact, wearable devices ... and from even deeper under the skin. , Recent work and visionary future directions ...
Breaking Biology Technology: