Navigation Links
Team receives $22.5 million to shed light on the immune system
Date:8/23/2012

LA JOLLA, CA, August 23, 2012 A team led by a scientist at The Scripps Research Institute has received a $22.5 million, five-year project renewal from the National Institutes of Health to uncover the workings of the immune system. This program has received ongoing support from NIH since 2002.

The grant is focused on innovative technologies that will ultimately provide data for improving a wide range of human diseases that include viral and bacterial infections and inherited immune disorders.

"I'm delighted the National Institute of Allergy and Infectious Diseases has decided to continue supporting this important research," said the grant's principal investigator Richard Ulevitch, who is a professor and chairman emeritus at Scripps Research. "Since the initiative began 10 years ago, the consortium has made seminal contributions to the field. Now, thanks to the new funding, there are more discoveries to come."

The project takes an unusual wide-angle "genetic and systems biology" approach to learning how we stay healthy in the face of numerous microbes in our environment. In contrast to traditional hypothesis-driven research, in which a single gene or protein is selected for study based on its proposed function, team members assemble information about multiple genes, proteins, and biochemical pathways without preconceived ideas about function. This data is then integrated and examined from multiple perspectives to understand the immune response as a whole.

In addition to Ulevitch and his group at Scripps Research, the consortium includes the laboratories of Alan Aderem of the Seattle Biomedical Research Institute, Bruce Beutler of University of Texas Southwestern Medical Center, Christopher Goodnow of the Australian National University, and Garry Nolan of Stanford University.

Ulevitch notes that the group is now especially interested in the intersection between innate and adaptive immunity. Innate immunity, our body's first line of defense, can destroy foreign invaders and trigger inflammation that contributes to their demise. If microorganisms make it past this gauntlet, the body calls on adaptive immunity. Here, T cells, B cells, antibodies, and killer cells come into play; the adaptive immune system also stores "memories" of the offending microorganisms to be on the alert for future attacks.

The team is using a genetic approach in mice, known as "forward genetics," to develop a detailed model of innate and adaptive immune responses to infection. "It is now crystal clear that data from mouse genetics provides insights into human disease," Ulevitch said. "When we started there were a lot more unknowns, but now there is a long list of genes identified in the mouse that cause both specific mouse phenotypes and are similarly linked to human disease."


'/>"/>
Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Related biology news :

1. University of Minnesota receives $13.1 million in DOE funding for 2 new nationwide centers
2. WPI receives $1.9 million from US Army to develop sensors that can save wounded soldiers
3. Clemson scholar receives top agriculture science award
4. The Johns Hopkins Center for Inherited Disease Research receives $101 million
5. Ben-Gurion University of the Negev receives $450,000 grant to conduct oil and natural gas research
6. Rutgers-Camden genetics researcher receives NSF CAREER Award
7. Salk Professor Terrence Sejnowski receives IEEE Frank Rosenblatt Award
8. IU biologist receives Department of Energys top young faculty award
9. Wyss Institute receives up to $37 million from DARPA to integrate organ chips to mimic the human body
10. China Botanic Receives Patent on its Schisandra Lignin Extraction Method
11. NASA Goddard scientist receives Presidential Early Career Award
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Team receives $22.5 million to shed light on the immune system
(Date:3/20/2017)... , March 20, 2017 At this year,s CeBIT ... -based biometrics manufacturer DERMALOG. The Chancellor came to the DERMALOG stand together ... is this year,s CeBIT partner country. At the largest German biometrics company ... use: fingerprint, face and iris recognition as well as DERMALOG´s multi-biometrics system.   ... ...
(Date:3/16/2017)... CeBIT 2017 - Against identity fraud with DERMALOG solutions "Made in Germany ... ... in one project, multi-biometric solutions provide a crucial contribution against identity fraud. (PRNewsFoto/Dermalog Identification Systems) ... Used combined in one project, multi-biometric solutions provide a crucial ... ...
(Date:3/9/2017)... , Australia , March 9, ... study data at the prestigious World Lung Imaging Workshop ... Andreas Fouras , was invited to deliver the ... pulmonary medicine. This globally recognised event brings together leaders ... share the latest developments in lung imaging. ...
Breaking Biology News(10 mins):
(Date:5/22/2017)... ... May 22, 2017 , ... Stratevi, a boutique firm that partners ... Coast. It has opened an office in downtown Boston at 745 Atlantic Ave. ... more important to generate evidence on the value they provide, not just to patients, ...
(Date:5/19/2017)... Shirley, New York (PRWEB) , ... May 19, 2017 , ... ... therapy techniques in treating gait disorders, Biodex Medical Systems, Inc. announces the release of ... time music therapy has been joined with a biomedical system to aid in rehabilitating ...
(Date:5/18/2017)... ... , ... NDA Partners Chairman Carl Peck, MD , announced today that ... President of Pharmaceutical Development Business Unit of Cardinal Health, has joined the firm as ... was former Chief Operating Officer at Anaborex, Senior VP and General Manager of the ...
(Date:5/18/2017)... ... May 17, 2017 , ... G-CON Manufacturing, Inc., the ... Officer, Maik Jornitz, was recognized as a Top 10 Industry Influencer on The ... “involved in bettering the pharma industry and bringing life-changing medicines to market” across ...
Breaking Biology Technology: