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Team led by Scripps Research scientists discovers body's own molecular protection against arthritis
Date:5/18/2010

ng that miR-140 retarded the disease. In contrast, the scientists found, transgenic mice that overexpressed miR-140 were resistant to developing the condition.

The team's findings fit in well with other recent research showing that an enzyme called Adamts-5 is necessary for osteoarthritis progression; miR-140 is known to regulate Adamts-5.

The team continues to investigate to learn more about the factors that control miR-140, the proteins it affects, and potential drugs that might influence its action.


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Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

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