Navigation Links
Team identifies new breast cancer tumor suppressor and how it works
Date:6/27/2011

CHAMPAIGN, Ill. Researchers have identified a protein long known to regulate gene expression as a potent suppressor of breast cancer growth. Their study, in the journal Oncogene, is the first to demonstrate how this protein, known as Runx3, accomplishes this feat.

"People suggested that Runx3 might be a tumor suppressor in breast cancer because they found that it is down-regulated in a lot of breast cancer cell lines and breast cancer tissues," said University of Illinois medical biochemistry professor Lin-Feng Chen, who led the study. But no previous studies uncovered direct evidence to support that idea, he said.

In the new study, Chen and his colleagues at Nagasaki University discovered that a significant proportion of mice lacking one of two Runx3 genes spontaneously developed mammary gland tumors at 14 or 15 months of life an age corresponding to age 40 to 50 in humans.

"We found mammary tumors growing in about 20 percent of the female mice lacking a copy of the Runx3 gene," Chen said. None of the mice with two normal copies of the gene developed tumors.

The researchers also found that estrogen receptor alpha (ER-alpha), a well-known culprit in the development of many breast tumors, was up-regulated in the mouse tumors. ER-alpha is overexpressed in about 75 percent of human cases of breast cancer, and enhanced ER-alpha expression in normal breast tissue is associated with an increased risk of breast cancer, Chen said.

Circulating estrogen binds to ER-alpha and initiates a chain of events that alter gene expression in the targeted cell. This is a normal part of cellular signaling, but in ER-positive breast cancers, the overexpression of ER-alpha leads to enhanced tumor cell survival, growth and proliferation.

The researchers found that when Runx3 was re-introduced into ER-alpha positive breast cancer cell lines, it suppressed the g
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2

Related biology news :

1. BUSM study identifies new potential approaches to treat myelofibrosis
2. Research identifies how cancer cells cheat death
3. TGen study identifies compounds that could slow down Alzheimers disease
4. AMIA identifies areas to strengthen Federal health IT strategic plan
5. 5-minute screen identifies subtle signs of autism in 1-year olds
6. Discovery identifies elaborate G-protein network in plants
7. La Jolla Institute identifies new therapeutic target for asthma, COPD and other lung disorders
8. Research identifies on-off switch for key factor in heart disease and cancer
9. Alzheimer’s disease consortium identifies four new genes for Alzheimer’s disease risk
10. Study identifies promising target for AIDS vaccine
11. Penn research identifies potential mechanisms for future anti-obesity drugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Team identifies new breast cancer tumor suppressor and how it works
(Date:8/22/2014)... available in German . ... PCFs proteins are fixated in a way so as ... the HZB and Fudan University researchers are planning on ... materials. Their findings are being published today in the ... Proteins are sensitive molecules. Everyone knows that at ...
(Date:8/22/2014)... a multifunctional enzyme that localizes to ... and cholesterol-synthesizing activities. DHCR24 overexpression confers ... β deposition. Dr. Xiuli Lu and ... constructed two recombinant adenoviruses (Ad-rSYN1-DHCR24-myc and ... in neuronal cells. They also found ...
(Date:8/21/2014)... team of scientists including researchers from the University of Georgia ... as canolain the journal Science . Their discovery paves ... used widely in farming and industry. , Canola is ... the winter crop is increasingly cultivated in Georgia. Canola oil ... of saturated fat and rich supply of omega-3 fatty acids, ...
Breaking Biology News(10 mins):Proteins: New class of materials discovered 2Canola genome sequence reveals evolutionary 'love triangle' 2
... "world summit" will bring together internationally renowned scientists from 12 ... India to address ancient microscopic fossils, from July 27 ... together the world,s best scientists in the field of ancient ... of the UCLA Institute of Geophysics and Planetary Physics, Center ...
... A University of Washington study of top-selling laundry products ... different chemicals. All six products tested gave off at ... federal laws, but none of those chemicals was listed ... in this topic because people were telling me that ...
... month remaining before the Beijing Olympics, Chinese officials have introduced ... Games. A new tool has been installed in the capital ... these efforts. Poor air quality could pose problems for ... outdoors in endurance sports, such as cycling and marathons. ...
Cached Biology News:UCLA 'world summit' to explore ancient life on Earth, and beyond 2Toxic chemicals found in common scented laundry products, air fresheners 2Toxic chemicals found in common scented laundry products, air fresheners 3Air quality forecasts for China 2
(Date:8/21/2014)... Aug. 21, 2014  Decision Resources Group finds ... and Mexico ... several newly approved agents, the anticipated label extension ... the launch of emerging biologics will substantially increase ... the emerging IL-5 inhibitors will introduce a new dynamic ...
(Date:8/21/2014)... KONG , Aug. 21, 2014  China Cord Blood ... announced its plan to release financial results for the ... 28, 2014, after market close in the US.  ... at 8:00 a.m. ET on Friday, August 29, 2014 ... overview of the Company,s recent developments, followed by a ...
(Date:8/21/2014)... Ontotext S4 , The Self Service ... Now the same enterprise hardened text mining, Linked ... data is available to start-ups and mid-size businesses at ... that do not have resources to evaluate and prototype ... since there is no need for on premise hardware ...
(Date:8/21/2014)... August 21, 2014 On Wednesday of last ... to use Redox Signaling molecules, became available for purchase in ... , "The way that RENU 28 works is, if you ... down of the rate of cellular renewal within your body. ... increasing of that rate of cellular renewal. What RENU 28 ...
Breaking Biology Technology:Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3China Cord Blood Corporation to Report First Quarter of Fiscal 2015 Financial Results 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4RENU 28 Skin Care Now Available in Australia and New Zealand 2
... up most of the tab for damage caused by invasive ... other goods imported from countries into the United States every ... financial damage of importing foreign insects into the nation and ... the journal PLoS One today. ,The ...
... Mass High Tech has selected Greenberg Traurig ... its 2011 All-Stars Award, one that recognizes 15 driven ... Camacho will be recognized for her wide ... sciences sector.  As a patent attorney, she represents pharmaceutical ...
... 9, 2011 PharmaVentures Limited, experts ... that they have been engaged by leading drug ... for an established full service CMC (chemistry, manufacturing ... The engagement will utilise PharmaVentures, asset divestment expertise ...
Cached Biology Technology:Homeowners, taxpayers pay billions to fight invasive pests 2Homeowners, taxpayers pay billions to fight invasive pests 3Greenberg Traurig Shareholder Jennifer A. Camacho Selected to Receive Mass High Tech's 2011 All-Stars Award 2