Navigation Links
Team identifies a molecular switch linking infectious disease and depression
Date:3/31/2009

Researchers at the University of Illinois report that IDO, an enzyme found throughout the body and long suspected of playing a role in depression, is in fact essential to the onset of depressive symptoms sparked by chronic inflammation.

Their study, just published online in the Journal of Immunology, is the first to identify IDO (indoleamine 2,3 dioxygenase) as a molecular switch that induces depressive symptoms in some cases of chronic inflammation.

Doctors have known for decades that patients with chronic inflammation, such as that linked to coronary heart disease or rheumatoid arthritis, are more likely than others to become depressed. Some pro-inflammatory drugs, such as interferon-alpha, which is used to treat Hepatitis C and a cancer known as malignant melanoma, also induce symptoms of depression in a significant number of patients.

In the new study, mice were exposed to Bacille CalmetteGurin (BCG), a vaccine used in many parts of the world to prevent tuberculosis. BCG produces low-grade, chronic inflammation in mice, which can be detected by measuring levels of certain immune system proteins, called inflammatory cytokines, in the blood and brain.

Mice exposed to BCG display the normal symptoms of illness (lack of appetite, reduced activity), but after these symptoms fade the mice continue to exhibit depressive-like behaviors that can be reversed with antidepressants, said animal sciences and pathology professors Keith Kelley and Robert Dantzer, who led the study.

Even after they recover from their sickness, the BCG-infected mice are much more passive than non-infected mice when in an inescapable situation. When placed in a bucket of water for a few minutes, for example, they struggle less to escape and spend more time floating passively, the researchers report.

"The mice that we're calling depressed give up more quickly. While physically able, the mice quit trying to escape," said animal s
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. UK researcher identifies just 8 patterns as the cause of all humor
2. Scripps research team identifies key molecules that inhibit viral production
3. Online collaboration identifies bacteria
4. International study identifies gene variants associated with early heart attack
5. MU researcher identifies possible genetic causes of borderline personality disorder
6. Stowers Institutes Baumann Lab identifies key step in maturation pathway of telomerase
7. Study identifies genetic variants giving rise to differences in metabolism
8. St. Jude identifies genomic causes of a certain type of leukemia relapse
9. LSUHSC research identifies key contributor to Alzheimers disease process
10. Pitt research identifies new target in brain for treating schizophrenia
11. Research identifies type of vaccine that holds promise in protecting against TB
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Team identifies a molecular switch linking infectious disease and depression
(Date:12/17/2014)... , Dec. 16, 2014 Research and Markets ... addition of the "Global Chemical Sensor Market ... http://photos.prnewswire.com/prnh/20130307/600769 One ... increasing demand for medical sensors in biomedical applications. ... for quick and correct diagnosis during surgical procedures. ...
(Date:12/15/2014)... , Dec. 12, 2014 Research and Markets ... addition of the "Global Facial Recognition Market ... http://photos.prnewswire.com/prnh/20130307/600769 Facial ... of individuals. Facial recognition system measures the overall ... jaw edges, mouth, and the distance between eyes. ...
(Date:12/11/2014)... 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition ... report to their offering. ... the adoption of multimodal biometric systems. Multimodal biometric ... individual for verification and identification purposes. This helps ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... AKRON, Ohio, June 16, 2011 Leaders within the ... to apply "Value-driven Engineering" (VdE) to enhance the development ... efficiency and reduced complexity.  VdE will become a key ... economy," maintain global competitiveness, and assure access to device ...
... Robert Blelloch, MD, PhD, has received the 2011 Outstanding Young ... for his pioneering research on the role of molecular tools ... Blelloch will present his research today, June 15, 2011, at ... p.m. EDT). He will participate in a press briefing at ...
... new Baylor University study has found that sunlight decreases the ... the southern United States every year. While golden algae ... Texas rivers and lakes, including Lake Whitney and Lake Waco ... believe that several environmental factors influence toxin production, but new ...
Cached Biology News:U.S. Biomedical Leaders Present a New National Device Innovation Strategy Based on "Value-driven Engineering" 2U.S. Biomedical Leaders Present a New National Device Innovation Strategy Based on "Value-driven Engineering" 3U.S. Biomedical Leaders Present a New National Device Innovation Strategy Based on "Value-driven Engineering" 4UCSF stem cell, cancer scientist honored for pioneering studies 2UCSF stem cell, cancer scientist honored for pioneering studies 3
(Date:12/17/2014)... , Dec. 17, 2014  United Therapeutics Corporation ... executive promotions as well as changes to Martine ... Executive Promotions United Therapeutics announced the ... and Co-Chief Executive Officer and David Zaccardelli , ... In connection with these promotions, Dr. Rothblatt,s title will ...
(Date:12/17/2014)... 2014   Synageva BioPharma Corp. (NASDAQ: ... for rare disorders, announced today its presentation at the ... San Francisco, CA. ... will present on Monday, January 12, 2015, at 9:00 ... webcast live and may be accessed from the "Webcasts ...
(Date:12/15/2014)... 2014 Organovo Holdings, Inc. (NYSE MKT: ... delivering breakthrough 3D bioprinting technology,  today celebrated continued ... its exVive3D TM Human Liver Tissue.  The ... commercial release on November 18, has been recognized ... awards for innovation. Most recently, on ...
(Date:12/15/2014)... , Dec. 15, 2014  Ascendis Pharma ... TransCon technology to address significant unmet medical needs, ... ongoing Phase 2 pediatric study to evaluate once-weekly ... deficiency, or GHD.  This interim analysis consists of ... total enrollment in the study, completing all six ...
Breaking Biology Technology:United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4Organovo Celebrates a Positive 2014 Reception of its exVive3DTM Human Liver Tissue Product 2Organovo Celebrates a Positive 2014 Reception of its exVive3DTM Human Liver Tissue Product 3Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4
... Inc. (Nasdaq:,NUVA), a medical device company focused on developing ... today,details relating to its fourth quarter and full year ... 19, 2008, after,the close of the market., NuVasive ... 2008 at,5:30 p.m. ET / 2:30 p.m. PT to ...
... of Directors of US,Oncology Holdings, Inc. and its wholly ... "Company") announced that, effective,February 1, 2008, Dale Ross will ... and will continue as the Executive Chairman of the,Company. ... Company,s,President and CEO. The CEO transition is a planned ...
... investors to state, TOPEKA, Kan., Jan. 25 ... a "Come Home to Kansas" initiative that,focuses on ... Kansas. Partners in this project include the Kansas,Department ... Organization and the KTEC PIPELINE., This initiative ...
Cached Biology Technology:NuVasive Announces Webcast and Conference Call of Fourth Quarter and Full Year 2007 Results 2NuVasive Announces Webcast and Conference Call of Fourth Quarter and Full Year 2007 Results 3US Oncology Announces Realignment of Executive Team 2US Oncology Announces Realignment of Executive Team 3'Come Home to Kansas' Announced by KTEC 2
Anti-Phospho-JKK/SEK1/MKK4 pAb Description: 100 g rabbit polyclonal antibody. Reacts with human/mouse/rat. Tested in WB. Research Focus: signal transduction Storage: -20C Shipping Tem...
...
... Concentrated x 10 This pH 9.9 ... prior to immunohistochemical staining procedures. It is ... mounted on glass slides. For particular antigens, ... especially effective. It should be noted that ...
... SeMet White to off-white solid. ... ≥98% by HPLC. Soluble in H 2 ... prior to use. RTECS EK7713840, CAS 3211-76-5, ... 13, 8515.Jornot, L., and Junod, A.F. ...
Biology Products: