Navigation Links
Team hopes to cut years off development time of new antibiotics
Date:2/11/2011

es only time will tell its effectiveness. Tam and Nikolaou, however, are employing computer modeling and simulation to project how bacteria would respond to different exposures of a drug, focusing on how much medicine a patient should take, how often it should be taken and for how many days. Subsequent investigations in clinical studies can then target those dosing methods that have the highest probabilities of success.

Tam, an expert on experimental therapeutics, and Nikolaou, with a background in computer-aided systems engineering, forged their collaboration through a seed grant from UH before they attracted external funding. Their modeling approach relies on fundamental laws of nature, which are exploited to generate future projections from scant experimental inputs through computer simulation. This has been demonstrated to be better than simple human eyeballing.

"Our approach gives us the ability to take extra variables into consideration in an attempt to develop a more robust computational tool that covers a wider spectrum of relevant scenarios in new drug development," Nikolaou said. "Some pharmaceutical companies are following our developments closely, and we are in the process of refining a model prototype in the form of a computer program to ultimately be used in a clinical setting."


'/>"/>

Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Test shows dinosaurs survived mass extinction by 700,000 years
2. The world can be powered by alternative energy, using todays technology, in 20-40 years
3. UF study of lice DNA shows humans first wore clothes 170,000 years ago
4. Without intervention, Mariana crow to become extinct in 75 years
5. 550 million years ago rise in oxygen drove evolution of animal life
6. Decline of West Coast fog brought higher coastal temperatures last 60 years
7. New book on 100 years of Illinois birds
8. Researcher explores the evolution of largest mammals over the past 100 million years
9. PAREXEL Completes 200 Patient Studies In Its Early Phase Units Over Three Years
10. German-Russian Otto Schmidt Laboratory in St. Petersburg funded for another 3 years
11. New statistical model moves human evolution back 3 million years
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Team hopes to cut years off development time of new antibiotics
(Date:8/29/2014)... stretch them, twist them, fold them: modern materials that ... potential, whether as artificial skin or electronic paper. , ... a challenge but a new way of working with ... a game-changer. , Previous success in the field ... use of precious gold and silver nanowires. , ...
(Date:8/28/2014)... of marine protected areas is needed to protect fish ... investigators from the Wildlife Conservation Society and other organizations, ... the largest numbers of species, often at the expense ... functions. , Many vital ecological functions of ... are food for millions of people. This study ...
(Date:8/28/2014)... Researchers at the University of Minnesota have developed ... to be used for muscle regeneration research as well ... FSHD. , The research is published in the current ... There is no treatment for FSHD, which is thought ... muscular dystrophy. FSHD is an unusual genetic disorder because, ...
Breaking Biology News(10 mins):Copper shines as flexible conductor 2Study finds marine protected areas inadequate for protecting fish and ocean ecology 2UMN researchers find animal model for understudied type of muscular dystrophy 2
... BLOOMINGTON, Ind. -- Two recently diverged populations of a ... contribute to the reproductive isolation that accompanies the origin ... of organic compounds present in the preen oils of ... Ecology . "There,s so much we don,t know ...
... Age and gender play a major role in how ... 20-to-64-year-olds. Published in the journal Psychophysiology , the investigation ... the Montreal Heart Institute in collaboration with colleagues from the ... findings suggest that women who are more defensive are at ...
... University of Western Ontario finds the sauces you use when ... benefits. The research, led by Western biology and psychology ... than just tasty sauces they can also provide a ... Mark Bernards and Christopher Guglielmo in Western,s department of biology. ...
Cached Biology News:Could smell play a role in the origin of new bird species? 2Could smell play a role in the origin of new bird species? 3Men and women respond differently to stress 2Spice up your health this barbecue season 2
(Date:8/28/2014)... A new research platform uses a laser ... structures undergoing stress and heating, an approach ... for microelectronics and batteries., This new technique, ... how heating and the surface stress of ... have discussed the merits of surface-stress influence ...
(Date:8/28/2014)... --  SunTrust Robinson Humphrey (STRH) today announced ... equity research team in biotechnology and oilfield services.  ... research demonstrates our commitment to providing our valued ... investment decision making," said Biff Woodruff , ... make significant investments in differentiated content at a ...
(Date:8/28/2014)... Woodstock, Vt. (PRWEB) August 28, 2014 ... microbiology testing around the world is available from ... industrial diagnostics companies. “ Industrial Microbiology Market Review, ... the Industrial Market ” (IMMR—4) tracks and compares ... in in North America, Europe and Asia, and ...
(Date:8/27/2014)... Lake City, Utah (PRWEB) August 27, 2014 ... construction that will expand its current Salt Lake City ... currently underway outside of Utah to ultimately create 1,000 ... next 20 years. , “Utah is home to ... of whom can be credited with Varian’s success in ...
Breaking Biology Technology:New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 32 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 3
... LPBP Inc. (LPBP) - At the request of,the ... of,the President and Chief Executive Officer and of ... of its interim filings for the quarters,ended January ... were,previously filed. The re-filing of these Certificates is ...
... Profitability, HARBIN, China, Aug. 15 /Xinhua-PRNewswire-FirstCall/ -- ... Board: CKGT), a,vertically integrated grower, developer, manufacturer and ... China, announced today record,second quarter results for the ... of $5.0 million, a 34.9% increase compared to ...
... 15 Catalyst,Pharmaceutical Partners, Inc. (Nasdaq: CPRX ... and six months ended June 30, 2008., ... program for,CPP-109," stated Patrick J. McEnany, Catalyst,s Chief ... dosing subjects in our U.S.,Phase II clinical trials ...
Cached Biology Technology:China Kangtai Cactus Biotech Announces Record Second Quarter Results 2China Kangtai Cactus Biotech Announces Record Second Quarter Results 3Catalyst Pharmaceutical Partners Reports Second Quarter 2008 Financial Results 2Catalyst Pharmaceutical Partners Reports Second Quarter 2008 Financial Results 3Catalyst Pharmaceutical Partners Reports Second Quarter 2008 Financial Results 4Catalyst Pharmaceutical Partners Reports Second Quarter 2008 Financial Results 5
... GenomePlex Single Cell Whole Genome Amplification ... on random fragmentation of genomic DNA ... fragments to PCR-amplifiable library molecules flanked ... achieved by PCR amplification of the ...
...
From formula-fed bovine calves Sterile, Cell culture tested...
Collected at a certified USDA establishment located within the United States. All final processing is done by Quad Five employees....
Biology Products: