Moving forward, the techniques used must be refined so that standard hospital MRI scanners can image the presence of 2-HG. "Developing methods to obtain images in a clinical setting is an engineering challenge now," Nelson said.
The work was a collaboration among several departments at UCSF, including Radiology and Biomedical Imaging; Bioengineering and Therapeutic Sciences; Pathology; and Neurological Surgery. The lead authors on the paper were Llewellyn Jalbert, a graduate student in the Bioengineering PhD program; and Adam Elkhaled, a staff researcher in the Department of Radiology and Biomedical Imaging.
It was funded by a $1.5 million-per-year National Cancer Institute grant called the Specialized Program for Research Excellence. Now in its 10th year of funding, the grant aims to translate basic laboratory and clinical discoveries into optimal ways of delivering treatment and monitoring a patient's progress.
The article, "Magnetic Resonance of 2-Hydroxyglutarate in IDH1-Mutated Low-Grade Gliomas" by Adam Elkhaled, Llewellyn E. Jalbert, Joanna J. Phillips, Hikari A. I. Yoshihara, Rupa Parvataneni, Radhika Srinivasan, Gabriela Bourne, Mitchel S. Berger, Susan M. Chang, Soonmee Cha and Sarah J. Nelson appeared in the Jan. 11, 2012 issue of the journal Science Translational Medicine.
|Contact: Jason Socrates Bardi|
University of California - San Francisco