Navigation Links
Team finds new way to image brain tumors and predict recurrence
Date:1/24/2012

After people with low-grade glioma, a type of brain cancer, undergo neurosurgery to remove the tumors, they face variable odds of survival depending largely on how rapidly the cancer recurs. Even though their doctors monitor the tumor closely with sophisticated imaging, it is difficult to determine with certainty whether cancer has returned in a more malignant state that requires aggressive treatment.

Now a team from the University of California, San Francisco (UCSF) has developed methods to reveal a molecular marker in tissue samples from brain tumors that has been linked to better survival odds. Monitoring this marker in the brain could provide doctors with a better way to follow their patients after surgery.

Though this technique has not yet been optimized for routine use in the clinic, it may help doctors better gauge cancer recurrence, make follow-up treatment decisions and assess how a patient responds to recommended treatments particularly in patients with low-grade forms of the cancer.

"If a tumor transforms to a higher grade, then it is important to use more aggressive treatments," said Sarah Nelson, PhD, the Margaret Hart Surbeck Distinguished Professor in Advanced Imaging at UCSF and a professor in the Department of Radiology and Biomedical Imaging.

The research group at UCSF used MRI methods to obtain data from image-guided tissue samples from more than 50 patients with glioma that demonstrated the presence of a chemical called 2-HG, linked to mutations in a gene known as IDH1. Studies in the last two years have shown these mutations are more common in low-grade tumors and are associated with longer survival. More than 70 percent of patients with low-grade gliomas have mutations to the IDH1 genes in their cancer cells.

Published this month in the journal Science Translational Medicine, the work required the use of specialized methods and equipment that was sensitive enough to detect the 2-HG in smal
'/>"/>

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert  

Page: 1 2

Related biology news :

1. CWRU study finds the love of a dog or cat helps women cope with HIV/AIDS
2. BU study finds new genetic loci associated with menopause onset
3. NASA finds 2011 ninth-warmest year on record
4. Mysterious flotsam in Gulf of Mexico came from Deepwater Horizon rig, WHOI study finds
5. Team finds a better way to gauge the climate costs of land use changes
6. Study finds age-related effects in MS may be reversible
7. Study finds air pollution linked to diabetes and hypertension in African-American women
8. MU researchers photoacoustic device finds cancer cells before they become tumors
9. Wayne State study finds soybean compounds enhances effects of cancer radiotherapy
10. Close family ties keep microbial cheaters in check, study finds
11. Study finds increasing atmospheric concentrations of new flame retardants
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Team finds new way to image brain tumors and predict recurrence
(Date:7/11/2014)... team of researchers from The Chinese University of Hong ... of wild soybean linked to salt tolerance, with implication ... soil. This study published online in Nature Communications ... information for crop improvement. , Soybean is an important ... selection, cultivated soybeans have less genetic diversities than their ...
(Date:7/11/2014)... group members to reduce aggression and gain access to ... grooming activities shows a certain pattern across the day. ... Biology Letters . , Grooming between individuals in ... motives. To be groomed has hygienic benefits and is ... can provide access to infants, mating opportunities and high ...
(Date:7/11/2014)... have explored two different ways that allow unprecedented ... the formation of oxygen molecules in photosynthesis. The ... journal Nature Communications . , "The new ... for water oxidation, which are key components for ... of solar energy in fuels like hydrogen, ethanol ...
Breaking Biology News(10 mins):BGI reports a novel gene for salt tolerance found in wild soybean 2Baboons groom early in the day to get benefits later 2Molecular snapshots of oxygen formation in photosynthesis 2
... are an important food source for fish and other aquatic ... this week in the Proceedings of the National Academy ... diets are supported by material that originates on land in ... to clarifying the role that watershed inputs play in aquatic ...
... BUFFALO, N.Y. -- An innovative, educational computing platform developed ... the cloud (remote, high-capacity, scalable servers) is helping UB ... new level. Soon, high-school and middle-school students will benefit ... by UB faculty members with a $250,000 National Science ...
... and Nanyang Technological University (NTU) are collaborating to enhance ... with oil., If successful, the wider application of the ... companies here to produce distilled water for their industrial ... at Singapore,s Jurong Island, which produce a lot of ...
Cached Biology News:Aquatic food web tied to land 2With cloud computing, the mathematics of evolution may get easier to learn 2With cloud computing, the mathematics of evolution may get easier to learn 3With cloud computing, the mathematics of evolution may get easier to learn 4memsys-NTU partnership to enhance water desalination technology 2
(Date:7/10/2014)... Angeles, CA (PRWEB) July 10, 2014 ... and Bioanalytical techniques during 18-20 August, 2014 at Double ... critically review the recent developments in Analytical & Bioanalytical ... the globe. , Speaking on this occasion, Dr. Srinubabu ... Analytica Acta conference is a remarkable one in ...
(Date:7/10/2014)... Ind. , July 10, 2014 /PRNewswire/ ... its use of capnography for respiratory monitoring ... group of healthcare leaders in embracing state-of-the-art ... how effectively patients are breathing and can ... occurs. By measuring the amount of carbon ...
(Date:7/10/2014)... , July 10, 2014 /PRNewswire-iReach/ -- Tute ... interpretation, today announced an agreement with Lineagen, ... for Lineagen,s NextStep Dx PLUS.  Lineagen, ... and neurological disorders, currently offers FirstStep Dx ... testing service used by healthcare providers as ...
(Date:7/10/2014)... 2014 -- According to the International Atomic Energy ... comes from terrorists acquiring sufficient quantities of plutonium ... crude nuclear explosive device. The IAEA also notes ... involved gram-level quantities, which can be challenging to ... a new study appearing this week in the ...
Breaking Biology Technology:A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Sensitive detection method may help impede illicit nuclear trafficking 2
... , , , For determining the optimal reagent for your cells , ... Contents , Kit Contents , Storage and Stability , ... Introduction , , , ... , , Effectene ...
... , QIAshredder spin columns are designed for simple and rapid homogenization , of cell ... , , Format: , ... , , Sample ... plant cell or tissue lysates, white blood cell lysates, , ...
... , , , Library siRNA is available against ... , Library siRNA is synthesised using patented TOM-Amidite chemistry, and , ... annealed, , desalted, and ready to use. A detailed certificate ... order. Library siRNAs are ready for transfection, , and are ...
Cached Biology Technology:Transfection Reagent Selector Kit Handbook 2Transfection Reagent Selector Kit Handbook 3Transfection Reagent Selector Kit Handbook 4Transfection Reagent Selector Kit Handbook 5Transfection Reagent Selector Kit Handbook 6Transfection Reagent Selector Kit Handbook 7Transfection Reagent Selector Kit Handbook 8Transfection Reagent Selector Kit Handbook 9Transfection Reagent Selector Kit Handbook 10Transfection Reagent Selector Kit Handbook 11Transfection Reagent Selector Kit Handbook 12Transfection Reagent Selector Kit Handbook 13Transfection Reagent Selector Kit Handbook 14Transfection Reagent Selector Kit Handbook 15Transfection Reagent Selector Kit Handbook 16Transfection Reagent Selector Kit Handbook 17Transfection Reagent Selector Kit Handbook 18Transfection Reagent Selector Kit Handbook 19Transfection Reagent Selector Kit Handbook 20Transfection Reagent Selector Kit Handbook 21Transfection Reagent Selector Kit Handbook 22Transfection Reagent Selector Kit Handbook 23Transfection Reagent Selector Kit Handbook 24Transfection Reagent Selector Kit Handbook 25Transfection Reagent Selector Kit Handbook 26Transfection Reagent Selector Kit Handbook 27Transfection Reagent Selector Kit Handbook 28Transfection Reagent Selector Kit Handbook 29Transfection Reagent Selector Kit Handbook 30QIAshredder Homogenizer 2
Biotin or fluorescent labels can be attached and the stoichiometry of protein labeling determined....
...
These macrocarriers are for the biolistic PDS-1000 He and Hepta systems. Supplied as 500 macrocarriers....
...
Biology Products: