Navigation Links
Team finds new way to image brain tumors and predict recurrence
Date:1/24/2012

After people with low-grade glioma, a type of brain cancer, undergo neurosurgery to remove the tumors, they face variable odds of survival depending largely on how rapidly the cancer recurs. Even though their doctors monitor the tumor closely with sophisticated imaging, it is difficult to determine with certainty whether cancer has returned in a more malignant state that requires aggressive treatment.

Now a team from the University of California, San Francisco (UCSF) has developed methods to reveal a molecular marker in tissue samples from brain tumors that has been linked to better survival odds. Monitoring this marker in the brain could provide doctors with a better way to follow their patients after surgery.

Though this technique has not yet been optimized for routine use in the clinic, it may help doctors better gauge cancer recurrence, make follow-up treatment decisions and assess how a patient responds to recommended treatments particularly in patients with low-grade forms of the cancer.

"If a tumor transforms to a higher grade, then it is important to use more aggressive treatments," said Sarah Nelson, PhD, the Margaret Hart Surbeck Distinguished Professor in Advanced Imaging at UCSF and a professor in the Department of Radiology and Biomedical Imaging.

The research group at UCSF used MRI methods to obtain data from image-guided tissue samples from more than 50 patients with glioma that demonstrated the presence of a chemical called 2-HG, linked to mutations in a gene known as IDH1. Studies in the last two years have shown these mutations are more common in low-grade tumors and are associated with longer survival. More than 70 percent of patients with low-grade gliomas have mutations to the IDH1 genes in their cancer cells.

Published this month in the journal Science Translational Medicine, the work required the use of specialized methods and equipment that was sensitive enough to detect the 2-HG in smal
'/>"/>

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert  

Page: 1 2

Related biology news :

1. CWRU study finds the love of a dog or cat helps women cope with HIV/AIDS
2. BU study finds new genetic loci associated with menopause onset
3. NASA finds 2011 ninth-warmest year on record
4. Mysterious flotsam in Gulf of Mexico came from Deepwater Horizon rig, WHOI study finds
5. Team finds a better way to gauge the climate costs of land use changes
6. Study finds age-related effects in MS may be reversible
7. Study finds air pollution linked to diabetes and hypertension in African-American women
8. MU researchers photoacoustic device finds cancer cells before they become tumors
9. Wayne State study finds soybean compounds enhances effects of cancer radiotherapy
10. Close family ties keep microbial cheaters in check, study finds
11. Study finds increasing atmospheric concentrations of new flame retardants
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Team finds new way to image brain tumors and predict recurrence
(Date:3/31/2015)... , March 31, 2015   Guidepoint , ... launch of the Post-Surgical Pain Management TRACKER, part of ... tracking usage trends in the medical device and therapeutics ... to data including treatment volumes, market share, and adoption ... pain associated with joint surgery. The Post-Surgical ...
(Date:3/24/2015)... 24, 2015   NexID Biometrics LLC, whose ... needs, today announced the beginning of shipments of version ... The company, based in Potsdam, N.Y. ... Connect:ID Expo, which began here today at the Walter ... 2.0 of its SDK boosts the accuracy rate range ...
(Date:3/23/2015)... , Mar. 23, 2015 NXT-ID, Inc. (NASDAQ: ... focused on the growing mobile commerce market, announces its biometric ... advertising campaign on CNBC television starting March 30 th ... commence airing in New York markets. ... said: "We are excited about our new ad campaign following ...
Breaking Biology News(10 mins):Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3
... A component of DNA that can both stimulate ... may hold hope for treating cancer and infection, Medical ... of CpG increase inflammation, part of the body,s way ... increasing expression of the enzyme indoleamine 2,3 dioxygenase, or ...
... A new study by researchers at Princeton University,s Woodrow ... that global climate change may lead to the retreat ... States, which could create unprecedented ecological restoration opportunities across ... time, global warming may enable other invasive plants to ...
... a surprising link between brain iron levels and ... from autism to major depression., Appearing in the ... this week, the study by Randy Blakely, ... a powerful in silico approach for discovering novel ...
Cached Biology News:DNA component can stimulate and suppress the immune response 2Climate change's impact on invasive plants in Western US may create restoration opportunities 2Climate change's impact on invasive plants in Western US may create restoration opportunities 3Climate change's impact on invasive plants in Western US may create restoration opportunities 4Researchers iron out new role for serotonin 2
(Date:4/28/2015)... April 28, 2015 IMS is ... bring it to the web and provide greater ... user friendly reporting metrics increase data warehouse’s utility; ... convenient recall and access “on-the-go” makes data analysis ... using client feedback to assist in repository analytics ...
(Date:4/28/2015)... Reproductive endocrinologist Dr. Kaylen Silverberg , ... battling infertility in this country, testified on behalf of ... first state in the nation to consider creating a clearinghouse ... who desire to receive them. , Infertility affects over 7.3 ... is one of the few medical diseases that is curable, ...
(Date:4/27/2015)... 27, 2015 Dr. Robert Hanzlik, whose ... toxicity carries implications for advancing the creation of safer ... National University , the second-largest private, nonprofit university ... Hanzlik, a professor at the University of Kansas School ... design, starts at 5 p.m. and takes place at ...
(Date:4/27/2015)... Kan. , April 27, 2015   ... a pet therapeutics company focused on the licensing, ... companion animals, today provided commentary on clinical study ... during a poster session at the American Association ... ADXS31-164 is a novel Lm -LLO ...
Breaking Biology Technology:Texas Fertility Center Supports a Groundbreaking HB1145 that Facilitates Embryo Donation in Texas 2Texas Fertility Center Supports a Groundbreaking HB1145 that Facilitates Embryo Donation in Texas 3Dr. Robert Hanzlik Discusses Pharmaceutical Testing Models at Event Hosted by National University 2Dr. Robert Hanzlik Discusses Pharmaceutical Testing Models at Event Hosted by National University 3Aratana Therapeutics Comments on ADXS31-164 (AT-014) Study Data Presented During Poster Session at the American Association for Cancer Research (AACR) Annual Meeting 2015 2
... TorreyPines Therapeutics, Inc. (Nasdaq: TPTX ) ... the Southern District of New York dismissed proceedings filed ... ("Axonyx") against Axonyx and several of Axonyx,s former directors ... plaintiffs alleged that the defendants made misleading statements related ...
... Enterprises, Inc. (BME), a rapidly growing medical device company ... implants, announced today that it has appointed Keith M. ... BME specializes in nitinol implants that contract and compress ... bone union. The O rthopaedic S ...
... Cell Trial to Show Dose-related Significant Improvement in Perfusion ... Amorcyte, Inc. (Amorcyte) today announced data from its Phase ... for the treatment of damaged heart muscle following acute ... cell dose and biologic effect. This is the first ...
Cached Biology Technology:Stockholder Suits Related to TorreyPines Therapeutics, Inc. Dismissed 2BioMedical Enterprises, Inc. (BME) Announces the Appointment of Keith M. Peeples as Vice President, Sales and Marketing 2Amorcyte Reports Phase I Results of AMR-001 to Improve Recovery From Severe Heart Attack at ACC Annual Scientific Session 2Amorcyte Reports Phase I Results of AMR-001 to Improve Recovery From Severe Heart Attack at ACC Annual Scientific Session 3Amorcyte Reports Phase I Results of AMR-001 to Improve Recovery From Severe Heart Attack at ACC Annual Scientific Session 4
... Streptavidin-Horseradish Peroxidase Conjugate, 2 ... reporter enzyme molecules for ... in situ hybridization applications.High ... & Labeling & Detection, ...
...
normal rat IgM AF647...
Chicken anti-EEA1...
Biology Products: