Navigation Links
Team finds link between stomach-cancer bug and cancer-promoting factor
Date:1/6/2010

Like other disease-causing bacteria, H. pylori have evolved to evade the body's defenses and even modify host proteins to help the bacteria survive.

Blanke and his graduate student Carlos Nossa previously had demonstrated that a protein factor released by H. pylori modifies an unidentified host protein in a manner consistent with an enzymatic reaction known as ADP-ribosylation. Other bacterial toxins, including cholera toxin and diphtheria toxin "ADP-ribosylate" host proteins in ways that enhance the survival or transmission of the bacteria that produce them.

"We were very excited about this finding, which we published in 2006," Blanke said. "We thought we had discovered a new toxin."

ADP-ribosylation can be tracked by incorporating a radio-isotope of phosphorous (32P) into a small molecule that is required for the reaction. During ADP-ribosylation, H. pylori transfers the 32P from the labeled molecule to a host protein, thereby tagging it with a radioactive fingerprint. Further analyses revealed that the radio-labeled host protein was PARP-1.

At this point, the team believed that the bacterium was ADP-ribosylating PARP-1. But when they genetically altered the functional regions of PARP-1, they completely blocked the H. pylori-dependent modification. Since PARP-1 also possesses poly-ADP-ribosylation enzymatic activity, which is necessary for its regulatory and DNA-repair function in cells, the team realized that something in the H. pylori arsenal was directly activating the PARP-1 enzymatic activity, rather than ADP-ribosylating it as they first suspected.

Additional studies validated that H. pylori indeed activates PARP-1 during infection of human gastric cells.

"These studies potentially provide a direct molecular link between H. pylori infection and the activation of a factor known to be involved in the survival of cancerous cells," Blan
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
2. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
3. Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
4. Study finds Viagra increases release of key reproductive hormone
5. Survey finds elevated rates of new asthma among WTC rescue and recovery workers
6. St. Jude finds factors that accelerate resistance to targeted therapy in lymphoblastic leukemia
7. Study finds a high rate of asthma in college athletes
8. Ecologist finds dire devastation of snake species following floods of 93, 95
9. Men shed light on the mystery of human longevity, study finds
10. JILA finds flaw in model describing DNA elasticity
11. Americans remain pessimistic about the environment, Stanford-AP survey finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Team finds link between stomach-cancer bug and cancer-promoting factor
(Date:9/16/2014)... , Sept. 16, 2014  Cross Match Technologies, ... solutions, announced today the launch of its Verifier ... the identity of an individual using their secure ... Sentry rapidly reads credential documents with embedded biometric ... matching the biometric to a live scan of ...
(Date:9/15/2014)... so-called central dogma of molecular biologythat DNA makes ... explanation for how genetic information is deciphered and ... of course, the process is vastly more complicated ... ago by Nobel Laureate Francis Crick, co-discoverer of ... multiple types of RNA, three of whichmessenger RNA ...
(Date:9/15/2014)... research has determined that a single group of microorganisms ... B12 production in the oceans, with implications for the ... B12 is an essential molecule required by most life ... relatively small group of microorganisms because it is so ... key role in maintaining the brain and nervous systems, ...
Breaking Biology News(10 mins):Cross Match Launches New Identity Management Handheld Solution 2Scientists discover RNA modifications in some unexpected places 2Researchers discover new producer of crucial vitamin 2
... between researchers at the Salk Institute for Biological Studies ... the genome-wide DNA methylation pattern of the plant Arabidopsis ... - in one big sweep. , "In a ... findings and then some," says senior author Joseph Ecker, ...
... of the deadliest threats to public health. Every year ... is caused by the microorganism Mycobacterium tuberculosis. Roughly one ... and more bacterial strains have developed resistance to drugs. ... Biology Laboratory (EMBL) and the Max Planck Institute for ...
... Northwestern University research group has discovered that aggressive ... critical to proper embryo formation. , An ... the advanced online issue of the journal Nature ... embryonic growth factor by injecting aggressive melanoma cells ...
Cached Biology News:In a technical tour de force, Salk scientists take a global view of the epigenome 2In a technical tour de force, Salk scientists take a global view of the epigenome 3New potential drug target in tuberculosis 2Malignant melanoma cells secrete protein required for embryo formation 2
(Date:9/16/2014)... NEW ORLEANS , Sept. 16, 2014 ... Austin, Texas -based cybersecurity company focused on ... 2FA ONE, will support the ability to generate a ... As a pioneer of user-based RFID authentication, ... used for physical access, for many years. RFID authentication ...
(Date:9/15/2014)... transitionsthink solid, liquid, and gasbut much stranger ... If phase transitions occur at the coldest ... fluctuations can dramatically transform a material. ... Energy,s Brookhaven National Laboratory and Stony Brook ... absolute zero to isolate and probe these ...
(Date:9/15/2014)... , Sept. 15, 2014  FlexTech Alliance today ... flexible, printed product demonstrators (demos) and a functional ... process with pre-proposals due on October 22, 2014 ... for proposals ultimately selected are provided by the ... significant cost share by the proposing organization. ...
(Date:9/15/2014)... team of researchers led by Northeastern University has ... inter-nanotube junctions and a variety of nanocarbon structures ... and easily scalable, which will allow the researchers ... for use in applications ranging from electronic devices ... cars to sports equipment. , Their findings were ...
Breaking Biology Technology:2FA, Inc. Announces RFID-based One-Time Password (OTP) Authentication 2Elusive quantum transformations found near absolute zero 2Elusive quantum transformations found near absolute zero 3FlexTech Alliance Issues 2015 Request for Proposals in Flexible, Printed Electronics 2Northeastern University Researchers Develop Novel Method for Working with Nanotubes 2
... be difficult for patients to do, and because of blinking ... the dose is actually absorbed by the eye. Now, researchers ... for Biomaterials and Drug Delivery at Children,s Hospital Boston, have ... amount of medication to the eye, at adjustable rates. They ...
... NEW YORK, July 21 /PRNewswire-Asia-FirstCall/ ... ), ("the Company" or "AOBO"), a pharmaceutical,company dedicated ... of a broad range of prescription and over ... AOBO was honorably elected as one of,the "Top ...
... , , KENILWORTH, N.J., ... financial results for the 2009 second quarter. , ... people have given us the strength to again power through tough challenges ... quarter," said Fred Hassan, chairman and CEO. , ...
Cached Biology Technology:A drug-dispensing contact lens 2American Oriental Bioengineering Honorably Elected a Top 20 Most Competitive Public Pharmaceutical Company in China 2Schering-Plough Reports Financial Results for 2009 Second Quarter 2Schering-Plough Reports Financial Results for 2009 Second Quarter 3Schering-Plough Reports Financial Results for 2009 Second Quarter 4Schering-Plough Reports Financial Results for 2009 Second Quarter 5Schering-Plough Reports Financial Results for 2009 Second Quarter 6Schering-Plough Reports Financial Results for 2009 Second Quarter 7Schering-Plough Reports Financial Results for 2009 Second Quarter 8Schering-Plough Reports Financial Results for 2009 Second Quarter 9Schering-Plough Reports Financial Results for 2009 Second Quarter 10Schering-Plough Reports Financial Results for 2009 Second Quarter 11Schering-Plough Reports Financial Results for 2009 Second Quarter 12Schering-Plough Reports Financial Results for 2009 Second Quarter 13Schering-Plough Reports Financial Results for 2009 Second Quarter 14Schering-Plough Reports Financial Results for 2009 Second Quarter 15Schering-Plough Reports Financial Results for 2009 Second Quarter 16Schering-Plough Reports Financial Results for 2009 Second Quarter 17Schering-Plough Reports Financial Results for 2009 Second Quarter 18Schering-Plough Reports Financial Results for 2009 Second Quarter 19Schering-Plough Reports Financial Results for 2009 Second Quarter 20Schering-Plough Reports Financial Results for 2009 Second Quarter 21Schering-Plough Reports Financial Results for 2009 Second Quarter 22Schering-Plough Reports Financial Results for 2009 Second Quarter 23Schering-Plough Reports Financial Results for 2009 Second Quarter 24Schering-Plough Reports Financial Results for 2009 Second Quarter 25Schering-Plough Reports Financial Results for 2009 Second Quarter 26Schering-Plough Reports Financial Results for 2009 Second Quarter 27
IgD Chain C (AMS 9.1)...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Applications: Epitope mapping, Mapping protein-protein contacts, Identification of enzyme substrates/inhibitors, Identification of receptor agonists/antagonists...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Biology Products: