Navigation Links
Team finds link between stomach-cancer bug and cancer-promoting factor
Date:1/6/2010

CHAMPAIGN, lll. Researchers report that Helicobacter pylori, the only bacterium known to survive in the harsh environment of the human stomach, directly activates an enzyme in host cells that has been associated with several types of cancer, including gastric cancer.

Chronic infection with H. pylori is a well-documented risk factor for several forms of gastric cancer, but researchers have not yet determined the mechanisms by which specific bacterial factors contribute to cancer development. Nearly one-half of the world's population is infected with H. pylori, and gastric cancer is one of the leading causes of cancer-related death.

The new study, in Proceedings of the National Academy of Sciences, is the first to show that a factor produced by the bacterium directly activates poly(ADP-ribose) polymerase-1 (PARP-1), an enzyme found primarily in the nucleus of animal cells. PARP-1 is a regulator of the host's inflammatory response and host cell death, both of which are hallmarks of H. pylori infection.

PARP-1 is best known as a normal part of the cellular machinery that repairs damaged DNA. But in certain types of cancer this enzyme actually enhances tumor survival and undermines chemotherapies designed to damage DNA in cancer cells. A recent human clinical trial found that drugs that inhibited PARP-1 reduced tumor growth in breast-cancer patients with mutations in certain DNA-repair (BRCA-1 and BRCA-2) genes. BRCA-1 mutations also are associated with an increased risk of stomach cancer.

The new study tackled the most urgent health problem associated with H. pylori infection, said Steven Blanke, a University of Illinois professor in the department of microbiology and Institute for Genomic Biology and principal investigator on the study.

"What is it about sustained infection with H. pylori that leads in some cases to the development of stomach cancer?" he said.


'/>"/>
Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
2. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
3. Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
4. Study finds Viagra increases release of key reproductive hormone
5. Survey finds elevated rates of new asthma among WTC rescue and recovery workers
6. St. Jude finds factors that accelerate resistance to targeted therapy in lymphoblastic leukemia
7. Study finds a high rate of asthma in college athletes
8. Ecologist finds dire devastation of snake species following floods of 93, 95
9. Men shed light on the mystery of human longevity, study finds
10. JILA finds flaw in model describing DNA elasticity
11. Americans remain pessimistic about the environment, Stanford-AP survey finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Team finds link between stomach-cancer bug and cancer-promoting factor
(Date:7/27/2014)... of "big data," a single computer cannot always find ... be distributed across a cluster of computers that analyze ... Google mine your web history to present you with ... next favorite book or movie. But big data is ... for monitoring brain activity are generating unprecedented quantities of ...
(Date:7/25/2014)... on the land now called California, and many of ... plants they used for food, fuel, tools, and ritual. ... habitat and natural resources. , Frank Lake, an ecologist ... lead a field trip to the Stone ... America,s 99th Annual Meeting, in Sacramento, Cal. this August. ...
(Date:7/25/2014)... (July 24, 2014)The link between autism and disrupted ... puzzle of the disease, and is largely unknown. ... Autism Research Initiative (SFARI), George Washington University (GW) ... offer truly integrative and in-depth answers to these ... , LaMantia, professor of pharmacology and physiology ...
Breaking Biology News(10 mins):New tools help neuroscientists analyze 'big data' 2New tools help neuroscientists analyze 'big data' 3New tools help neuroscientists analyze 'big data' 4New tools help neuroscientists analyze 'big data' 5Fire ecology manipulation by California native cultures 2Fire ecology manipulation by California native cultures 3GW researcher receives grant to answer the how and why of autism during development 2
... July 9, 2012 Bovine spongiform encephalopathy (BSE, or "mad ... portions of the brain to turn sponge-like. This transmissible ... of protein known as a prion, rather than by a ... signs of illness is about 60 months. Little is known ...
... miles at 150mph, how long will it take to reach ... question makes you apprehensive, then you may have mathematics anxiety. ... journal Behavioral and Brain Functions reports that a ... both genders, performance is likely to be affected as a ...
... MAResearchers from Brigham and Women,s Hospital (BWH) have made a ... The team, led by Thomas S. Kupper, MD, chair of ... that high expression of a cell-signaling molecule, known as interleukin-9, ... findings will be published online in the July 8, 2012 ...
Cached Biology News:Study finds 'mad cow disease' in cattle can spread widely in ANS before detectable in CNS 2Girls' mathematics performance more likely to suffer than boys' as a result of mathematics anxiety 2Researchers discover molecule in immune system that could help treat dangerous skin cancer 2
(Date:7/25/2014)... -- Research and Markets  has announced the ... report to their offering. ... Metabonomics is the scientific study of chemical processes ... technique that is being widely used in biology, ... molecules that are present in blood, urine, and ...
(Date:7/25/2014)... San Diego, CA (PRWEB) July 25, 2014 ... “Paws” For Your Pet with Lorry Young will be ... DVM, to talk about stem cell therapy in pets. ... discuss the benefits of stem cell therapy for pets suffering ... developments moving the Regenerative Veterinary Medicine industry forward. , Young ...
(Date:7/25/2014)... 2014 Lawrence Livermore scientists Charles Westbrook ... list of " The World's Most Influential Scientific Minds ... 3,000 researchers who were identified by analyzing citation data ... published the highest-impact work (2002-2012 and 2012-2013). The two ... combustion modeling . , "This recognition is a great ...
(Date:7/25/2014)... 2014 /PRNewswire-iReach/ -- Xybion Corporation, the leading provider ... operating in highly regulated industries, announced today that ... User Group Conference, Xybion International Exchange, on October ... at the Sheraton Society Hill Hotel.  ... This year,s conference theme is Compliance ...
Breaking Biology Technology:Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 3Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4Xybion Announces It Will Host International User Conference in Philadelphia 2Xybion Announces It Will Host International User Conference in Philadelphia 3
... is writing a series of articles on raising capital from investors. ... Most of the time when raising equity capital, the offering terms ... sheet . When dealing with angel investors , it ... , ,Sometimes prospective angel investors will want to negotiate the initial ...
... Oren Harari is coming to Milwaukee next week for ... , ,Not just to manufacturers, who he will be addressing at ... organizations in a number of sectors, including technology. , ,Based on ... in a Copycat Economy , he intends to deploy some provocative ...
... - Mithridion, Inc ., a biopharmaceutical start up that ... has closed an additional $1.2 million of Series A funding ... round of funding brings the total equity capital raised in ... initial funding target. Mithridion will use the funds to develop ...
Cached Biology Technology:Capital-raising term sheets for angels and venture capitalists 2Capital-raising term sheets for angels and venture capitalists 3Capital-raising term sheets for angels and venture capitalists 4Capital-raising term sheets for angels and venture capitalists 5Visions: Innovating like Madonna and Willie Nelson (and Steve Jobs) 2Visions: Innovating like Madonna and Willie Nelson (and Steve Jobs) 3Alzheimer's drug developer lands $1.2M in venture funding 2Alzheimer's drug developer lands $1.2M in venture funding 3
384 Well PCR Plate Carrier for Thermo-Sealer...
... Collection of Cell Cultures (ECACC) has been ... academia and government institutes for over seven ... designed to introduce candidates to cell culture ... on more specialist areas such as planning ...
...
... used to perform runs with and ... Experion automated electrophoresis system. The software ... gel views and summarizes size, concentration, ... table. This software is for use ...
Biology Products: