Navigation Links
Team finds gene that promotes drug resistance in cancer
Date:1/14/2013

Scientists from the University of Iowa and Brigham Young University (BYU) have identified a gene that may be a target for overcoming drug resistance in cancer. The finding could not only improve prognostic and diagnostic tools for evaluating cancer and monitoring patients' response to treatment but also could lead to new therapies directed at eradicating drug-resistant cancer cells.

Drug resistance is a common problem in many metastatic cancers. It leads to failure of chemotherapy treatments and is associated with poor patient outcomes, including rapid relapse and death.

The research team, including Fenghuang (Frank) Zhan, M.D., Ph.D., and Guido Tricot, M.D., Ph.D., from the UI, and David Bearss, Ph.D., from BYU, initially focused on identifying genes linked to the development of drug resistance in multiple myeloma, a bone marrow cancer that affects more than 20,000 Americans and causes almost 11,000 deaths annually.

Working with serial biopsied cells from 19 myeloma patients, the researchers analyzed genetic changes in the cells that occurred over the course of treatment with very intensive chemotherapy drugs. This approach identified a gene called NEK2 that is strongly associated with increased drug-resistance, faster cancer growth, and poorer survival for patients. The study was published Jan. 14 in the journal Cancer Cell.

Having established the relationship between high expression of the NEK2 gene and poor patient outcome in myeloma, the team then examined the relationship in other common cancers -- including breast, lung, and bladder cancer -- by analyzing gene expression profiles from 2,500 patients' cells with eight different cancers in Zhan's lab.

"In all cases, an increase in the NEK2 gene was associated with rapid death of the patient," says Tricot, who is director of Holden Comprehensive Cancer Center's Bone Marrow Transplant and Myeloma Program at UI Hospitals and Clinics. "So this finding was not
'/>"/>

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-356-7124
University of Iowa Health Care
Source:Eurekalert

Page: 1 2

Related biology news :

1. MIT research: Study finds room to store CO2 underground
2. Study finds circle hooks lower catch rate for offshore anglers
3. LSUHSC research finds HPV-related head & neck cancers rising, highest in middle-aged white men
4. Head and body lice appear to be the same species, genetic study finds
5. Study finds peoples niceness may reside in their genes
6. Large international study finds memory in adults impacted by versions of 4 genes
7. Improved loblolly pines better for the environment, study finds
8. NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
9. As deadly cat disease spreads nationally, MU veterinarian finds effective treatment
10. Study finds cancer-fighting goodness in cholesterol
11. Study finds soda consumption increases overall stroke risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Oct. 20, 2014 The Nano-Bio Manufacturing Consortium ... Force Research Laboratory (AFRL), has chosen a project proposed ... the University of Arizona College of Medicine – ... AzCIM project,s goal is to assess different sweat collection ... volumes of sweat under a variety of human-body conditions, ...
(Date:10/18/2014)... stress-related psychiatric disorders are associated with increased ... mechanisms underlying this relation are unknown. Understanding ... of targeted preventive strategies and new or ... work is presented at the European College ... international group of researchers from Germany and ...
(Date:10/17/2014)... available in German . ... every day in order to reproduce? And why are there ... of the latest issue of the research journal Molecular ... biologist Steven Ramm from Bielefeld University Bielefeld has compiled this ... unusual for a female to copulate with several males in ...
Breaking Biology News(10 mins):Nano-Bio Manufacturing Consortium Selects Project Proposed by Arizona Center for Integrative Medicine to Optimize Human Performance Monitoring Techniques 2Nano-Bio Manufacturing Consortium Selects Project Proposed by Arizona Center for Integrative Medicine to Optimize Human Performance Monitoring Techniques 3Researchers find why depression and aging linked to increased disease risk 2Sperm wars 2
... of time, knowledge and training in health promotion and ... the top barriers to including effective physical activity counseling ... The University of Texas School of Public Health, part ... Houston (UTHealth). "Individual and organization barriers must be ...
... DNA can trigger tumorigenesis. Researchers from Ludwig-Maximilians-Universitaet (LMU) ... a protein involved in the repair and signaling ... light on the origins of neurodegenerative diseases and ... or environmental toxins can cause double-stranded breaks in ...
... have found that acceptance of the site of a ... economic background. Writing in the International Journal of Environmental ... more often have a positive opinion on the location ... While the actual quantities of nuclear waste around the ...
Cached Biology News:UTHealth study addresses barriers to physical activity counseling 2UTHealth study addresses barriers to physical activity counseling 3Where to put nuclear waste? 2
(Date:10/25/2014)... RESTON, Va. (PRWEB) October 24, 2014 ... (WEDI), the nation’s leading nonprofit authority on ... in healthcare information exchange, announces its appointment of ... Privacy Workgroup. The workgroup leaders include:, ... Optum ,     Erik Pupo, Specialist Leader, Deloitte ...
(Date:10/25/2014)... Addison, TX (PRWEB) October 24, 2014 ... skincare products, announced the winners of its “Reflect Your ... who have not only seen a difference in their ... also experienced a new outlook on life as a ... Youth” contest originated as an effort by Nerium International ...
(Date:10/25/2014)... 2014 A new way to produce ... of current skin grafting technologies, it also speeds up ... method, outlined in the October issue of STEM CELLS ... skin injuries that result from severe burns and chronic ... skin’s regenerative elements. These wounds heal by contraction, with ...
(Date:10/25/2014)... , October 24, 2014 ... clinical-stage pharmaceutical company focused on the development of oral ... Nadav Kidron will present at FireRock Capital,s ... Capital,s Annual Micro-Cap Conference ,Date: Tuesday, October 28, 2014 ... New York City , ...
Breaking Biology Technology:WEDI Appoints Four New Security and Privacy Workgroup Co-chairs 2Nerium International™ Inspires Conversation About the Journey of Aging with “Reflect Your Youth” Contest 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 3Oramed to Present at the FireRock Annual Micro-Cap Conference 2Oramed to Present at the FireRock Annual Micro-Cap Conference 3
... an Educational Webinar "How Organizations Can Make the Transition ... featuring Virtify, Inc. , , CAMBRIDGE, Mass., ... ), the market leader in Enterprise Content Compliance solutions ... ), a provider of Enterprise Compliance and Quality ...
... -- China-Biotics,Inc. (Nasdaq: CHBT ) ("China-Biotics," ... manufacture, research, development, marketing and,distribution of probiotics products ... management will present at the upcoming,China Rising Conference ... on May 18,2009. , ...
... April 30 Amicus Therapeutics (Nasdaq: FOLD ... the regular close of markets on Thursday, May 7, ... live conference call and webcast that afternoon at 5 ... conference call at 5 p.m. EDT by dialing 877-874-1565 ...
Cached Biology Technology:Event Alert: 'SPL R4 Compliance and its Impact on Regulatory Submission Processes' 2Event Alert: 'SPL R4 Compliance and its Impact on Regulatory Submission Processes' 3China-Biotics, Inc. to Present at CCG Investor Relations' China Rising Conference 2China-Biotics, Inc. to Present at CCG Investor Relations' China Rising Conference 3Amicus Therapeutics Announces First Quarter 2009 Financial Results Release Date 2
Antibodies were affinity purified using epitopes specific to UBAP2L/NICE4 immobilized on solid support....
UltraPure DNase/RNase-Free Distilled Water is designed for use in all molecular biology applications. It is 0.1-m membrane-filtered and tested for DNase and RNase activity....
...
Water Distilled (Gibco™) is membrane filtered and endotoxin screened....
Biology Products: