Navigation Links
Team finds breast cancer gene linked to disease spread
Date:1/5/2009

signatures," making it difficult to identify overlapping, functionally relevant genes that might be important targets for therapeutic intervention.

The scientists in this study addressed this problem by using an innovative computational biology approach. They re-analyzed massive clinical breast cancer databases and found that study after study showed one area in common -- a very small region in human chromosome 8 called 8q22. They found that this area of the chromosome is repeated many times in the genomes of poor-prognosis breast tumors. Some chromosomes contained as many as eight copies or "repeats" of the genetic segment. Most normal DNA sequences contain only two copies of a given gene, conveyed from the genomes of the male and female parents.

Next, the team studied breast tumor samples collected from patients at The Cancer Institute of New Jersey. In doing so, the researchers were able to validate the computational prediction, confirming that the genetic sequence identified in the database was overproduced in the DNA of the poor-prognosis tumor samples.

The researchers went on to discover that among a handful of genes in the 8q22 region, MTDH is responsible for the aggressive behavior of poor-prognosis tumors. They used recombinant DNA technology to enhance the expression of individual genes in the region, one by one, in breast tumor cells and tested their metastatic behavior in laboratory mice.

The scientists found that MTDH-overexpressing tumors are more likely to metastasize to the lungs, other vital organs and bones. Importantly, these tumors were also found to be more resistant to a wide range of chemotherapeutic agents, including paclitaxel, cisplatin and adriamycin. When researchers genetically altered the cancer cells to reduce the expression of MTDH, these tumor cells become less able to metastasize and more likely to be eliminated by chemotherapy agents.

"This is probably one of the first examples of
'/>"/>

Contact: Kitta MacPherson
kittamac@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Case Western Reserve finds mechanism underlying alt. splicing of premessenger RNA into messenger RNA
2. Proactive care saves lives of seniors, study finds
3. Joslin research finds nearly three-quarters of youths with diabetes insufficient in vitamin D
4. Ireland Cancer Center researcher finds most triple-negative breast cancers express muc-1 target
5. Princeton-led team finds secret ingredient for the health of tropical rainforests
6. Rice University study finds possible clues to epilepsy, autism
7. U of Minnesota researcher finds link between aggression, status and sex
8. Men are red, women are green, Brown researcher finds
9. Brown chemist finds gray molds killer gene
10. Dolphin population stunted by fishing activities, Scripps/NOAA study finds
11. Pitt research finds that low concentrations of pesticides can become toxic mixture
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Team finds breast cancer gene linked to disease spread
(Date:9/29/2014)... 210 million years ago when the supercontinent of Pangea was ... nearly everything, entirely different kinds of reptiles called phytosaurs and ... It was widely believed the two top predators didn,t interact ... the latter ruled the land. But those ideas are changing, ... In a paper published online in September in the German ...
(Date:9/29/2014)... a combination of a real-time feedback system together with ... resulted in a reduction of 37% in energy consumption ... kWh, which is equivalent to a reduction of 713.71 ... , In contrast, another eight halls, exposed only to ... in saw a 3.5% reduction in energy consumption. , ...
(Date:9/29/2014)... 2014 Growing Demand From ... Increasing Security Concerns Continue to Propel Biometrics Market ... is one of the fastest growing biometrics ... systems, majorly in various government projects such as ... based biometrics dominates the country,s biometrics market, with ...
Breaking Biology News(10 mins):Tooth buried in bone shows prehistoric predators tangled across land, sea 2India Biometrics Market to Surpass USD2.7 Billion by 2019, Finds TechSci Research Study 2India Biometrics Market to Surpass USD2.7 Billion by 2019, Finds TechSci Research Study 3
... Boston, MA - Tiny particles only billionths of a meter ... human haircould offer big hope in a small package to the ... everything from jewelry to coins and cell phones, say scientists at ... issue of Nature Nanotechnology, the team will report a ...
... the largest study of its kind, researchers from a consortium ... linked to late-onset Alzheimer,s disease. Each of these genes adds ... the disease, and together they offer a portal into the ... to determine who is at risk of developing the disease, ...
... Medicine researchers are part of a consortium that has identified ... a person developing Alzheimer,s disease later in life. The ... The consortium also contributed to the identification of a ... United States and Europe. "Mount Sinai has unique resources ...
Cached Biology News:Nanoparticles offer hope for common skin allergy 2Nanoparticles offer hope for common skin allergy 3Alzheimer’s disease consortium identifies four new genes for Alzheimer’s disease risk 2Alzheimer’s disease consortium identifies four new genes for Alzheimer’s disease risk 34 new genes identified for Alzheimer's disease risk 2
(Date:9/29/2014)... -- The 12th Cold Chain GDP & Temperature Management ... at the John B. Hynes Convention Center. The remarkable ... for a weeklong conference attracting industry executives from around ... to cover the industry,s most pressing topics, with an ... range products, GDP compliance requirements and supply chain integrity. ...
(Date:9/29/2014)...  Perrigo Company plc (NYSE: PRGO ... a portfolio of preclinical research assets, which it ... Corporation plc, to drug discovery and development company, ... will receive an upfront payment in addition to ... future sales derived from the portfolio. ...
(Date:9/29/2014)... Sept. 29, 2014  Xcenda, the strategic consulting ... pharmaceutical sourcing and distribution service companies, recently conducted ... This research was analyzed in an economic model ... with an increase in life years and a ... population-level coffee consumption across the United ...
(Date:9/29/2014)... Westbridge Agricultural Products announced today ... highly effective new tool for organic growers. SUPPRESS™ ... contact herbicide for post-emergent, non-selective weed control for ... The formulation is an emulsifiable concentrate that has ... (OMRI) for use in organic food production. , ...
Breaking Biology Technology:12th Cold Chain GDP & Temperature Management Logistics Global Forum Officially Kicks Off in Boston 2Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 2Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 3Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 4Coffee Consumption May Increase Survival and Reduce Healthcare Costs 2Coffee Consumption May Increase Survival and Reduce Healthcare Costs 3Westbridge Receives EPA Approval for Its New SUPPRESS™ Herbicide EC 2
... RANCHO CORDOVA, Calif., Aug. 30 ThermoGenesis Corp. (Nasdaq: ... services that process and store adult stem cells, said today ... Ltd. (HealthBanks). HealthBanks, which operates cord blood banks ... a total of 20 BioArchives and a storage capacity for ...
... -- PARIS, August 30, 2010 ... ... var shortURL = ""; ... we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; break; ...
... Bioheart, Inc., (OTC Bulletin Board: BHRT ) ... with stem cell therapy on the first two congestive ... Angeles Tijuana through its Center of Excellence, Regenerative Medicine ... an agreement to establish a Center of Excellence for ...
Cached Biology Technology:ThermoGenesis Announces Sale of BioArchive Systems In Asia as Company Increases Presence In Key Market 2ThermoGenesis Announces Sale of BioArchive Systems In Asia as Company Increases Presence In Key Market 3ATOLL Study Results With Intravenous Enoxaparin in Acute Heart Attack Managed with Urgent Angioplasty 2ATOLL Study Results With Intravenous Enoxaparin in Acute Heart Attack Managed with Urgent Angioplasty 3ATOLL Study Results With Intravenous Enoxaparin in Acute Heart Attack Managed with Urgent Angioplasty 4ATOLL Study Results With Intravenous Enoxaparin in Acute Heart Attack Managed with Urgent Angioplasty 5ATOLL Study Results With Intravenous Enoxaparin in Acute Heart Attack Managed with Urgent Angioplasty 6ATOLL Study Results With Intravenous Enoxaparin in Acute Heart Attack Managed with Urgent Angioplasty 7Bioheart Reports Significant Improvements in Heart Failure Patients from Center of Excellence Program 2Bioheart Reports Significant Improvements in Heart Failure Patients from Center of Excellence Program 3Bioheart Reports Significant Improvements in Heart Failure Patients from Center of Excellence Program 4
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
...
...
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
Biology Products: