Navigation Links
Team finds breast cancer gene linked to disease spread
Date:1/5/2009

s a real shot at developing a drug that will inhibit metastasis."

The multidisciplinary research strategy used by the team to pinpoint the gene in breast cancer patients also could be used to find other genes involved in the spread of other cancers, scientists said.

"The potential health implications of this study are significant," Kang said.

The discovery is based on three years of work, using an approach that combines the emerging science of integrative genomics with the classical methods of clinical research and laboratory experiments.

"This paper is a great illustration of the way in which bioinformatics can be synergistically combined with experimental work to produce important results," said David Botstein, director of Princeton's Lewis-Sigler Institute for Integrative Genomics.

From the beginning, the scientists were looking for a way to understand the dreaded process of metastasis, the term describing what happens when cancer spreads to distant vital organs, such as the lungs, liver, brain and even the bones.

As the scientists well understood, patients whose breast cancer can be confined to the breast have the best chances at survival. The five-year survival rates, as compiled by the National Cancer Institute, illustrate the difference between localized and metastatic cancer: 98.1 percent of patients with localized breast cancer survive five years after diagnosis, as opposed to 27.1 percent for patients with cancer that has traveled beyond the lymph nodes to bodily organs, according to the federal agency's statistics.

In recent years, researchers have used advanced techniques such as DNA microarray technology to try and identify genetic profiles of the so called "poor prognosis" tumors -- those that are likely to come back after the initial treatment and are most likely to spread beyond the breast. Such studies, though useful in predicting outcomes, have perplexingly offered up differing gene "
'/>"/>

Contact: Kitta MacPherson
kittamac@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Case Western Reserve finds mechanism underlying alt. splicing of premessenger RNA into messenger RNA
2. Proactive care saves lives of seniors, study finds
3. Joslin research finds nearly three-quarters of youths with diabetes insufficient in vitamin D
4. Ireland Cancer Center researcher finds most triple-negative breast cancers express muc-1 target
5. Princeton-led team finds secret ingredient for the health of tropical rainforests
6. Rice University study finds possible clues to epilepsy, autism
7. U of Minnesota researcher finds link between aggression, status and sex
8. Men are red, women are green, Brown researcher finds
9. Brown chemist finds gray molds killer gene
10. Dolphin population stunted by fishing activities, Scripps/NOAA study finds
11. Pitt research finds that low concentrations of pesticides can become toxic mixture
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Team finds breast cancer gene linked to disease spread
(Date:11/21/2014)... Nov. 19, 2014  Earlier this year Donald ... College, and one of the most prolific inventors in ... are transmitted from Smartphones to third party agencies. Spector ... has one of the earliest known patents in this ... in the military, child care, elder care and hospital ...
(Date:11/21/2014)... C-Labs LLC, a leading provider of remote ... today announced the appointment of John Traynor ... strategic advisor to the firm, Mr. Traynor will now ... based out of the C-Labs office in ... Muench , Chief Executive Officer. Photo - ...
(Date:11/18/2014)...  The Secure Identity & Biometrics Association (SIBA) ... the formation of The Airport Entry and Exit ... and Biometric Entry and Exit Solutions Framework for ... from BORDERPOL, the international non-profit organization that works ... regarding border security, traveler and migration systems. ...
Breaking Biology News(10 mins):Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
... of the International Society for Sexually Transmitted Disease Research ... City, Canada. The world,s foremost conference in the ... from every continent to discuss the most recent developments ... emerging threats in bacterial STDs; major intervention programs for ...
... University of Georgia researcher has invented a new ... clothing, face masks, paper towelsand yes, even diapers, ... germ-free. The simple and inexpensive anti-microbial technology ... can be applied during the manufacturing process or ...
... are developing new technologies that combine a laser ... particles such as bacteria, viruses and DNA for ... to food safety. The technologies could bring ... or miniature instruments that perform measurements normally requiring ...
Cached Biology News:New UGA technology makes textiles permanently germ-free; targets health care-associated infections 2New UGA technology makes textiles permanently germ-free; targets health care-associated infections 3Laser, electric fields combined for new 'lab-on-chip' technologies 2Laser, electric fields combined for new 'lab-on-chip' technologies 3
(Date:12/24/2014)... MD (PRWEB) December 23, 2014 ... into law H.R. 83, the Omnibus and Continuing ... first time, made hydrocephalus a condition eligible to ... Programs (CDMRP) administered by the Department of Defense ... with its allies on Capitol Hill, is celebrating ...
(Date:12/24/2014)... The report expects global cell isolation and expansion market ... a carefully analyzed data about the vital drivers, restraints, ... Full Copy of Report @ http://bit.ly/1yUxy0T , ... expansion will keep witnessing growth at an impressive CAGR ... driven by rapid technological advancements, government funding and investments, ...
(Date:12/24/2014)... PharmaBoardroom,s new report, , Healthcare and ... free download , digs deep into this vibrant market, ... sector today. One area where Algeria ... a homegrown pharmaceutical manufacturing base, even if the government,s ambitious ... off. A cursory comparison with neighboring Morocco ...
(Date:12/22/2014)... 2014 The Center for Professional ... technical training across the life sciences industry, has partnered ... (SCDM) to provide the organization's members with discounted classroom ... to the more than 350 sessions across 80 course ... off when registering for a public course ...
Breaking Biology Technology:Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3
... In a video interview, new CEO,Andrew Witty comments on ... strategic vision for the business., The ... diversified global business - Deliver more products of value ... and vodcast are available now on, http://www.cantos.com . It,s free ...
... 23 Duska Therapeutics,Inc. (OTC Bulletin Board: DSKA) ... a synopsis of a proposed Phase 3 clinical ... Food and Drug Administration,s (the,"FDA") Division of Cardiovascular ... with the FDA, including a face-to-face,meeting held on ...
... Next generation design reduces the amount of retraction needed for surgical ... ... July 23 Pioneer Surgical Technology,today announces the market availability of ... optimize,anterior cervical fusion procedures while addressing the clinical needs of,anterior cervical ...
Cached Biology Technology:Duska Therapeutics Submits Phase 3 ATPace(TM) Protocol to FDA for Comment 2Duska Therapeutics Submits Phase 3 ATPace(TM) Protocol to FDA for Comment 3Duska Therapeutics Submits Phase 3 ATPace(TM) Protocol to FDA for Comment 4Pioneer(R) Surgical Technology, Inc. Announces the Market Launch of the SlimFuse(TM) Anterior Cervical Plate System 2
Guanylate Kinase Purified Anti-Mouse, Anti-Rat clone 28, Isotype Mouse IgG 1 , 50 µg Consult technical datasheet for details....
Proliferin (C-14)...
... the computing power of your ValveBank system! ... sequences with a Macintosh computer using graphic ... to disk, print out program listings, then ... in one simple step., EasyCode is used ...
... series of Class II Biological Safety ... certification to the world's highest safety ... the cabinets cannot be adjusted out ... low noise and arm rest ensure ...
Biology Products: