Navigation Links
Team discovers how bacteria resist a 'Trojan horse' antibiotic
Date:3/19/2012

CHAMPAIGN, lll. A new study describes how bacteria use a previously unknown means to defeat an antibiotic. The researchers found that the bacteria have modified a common "housekeeping" enzyme in a way that enables the enzyme to recognize and disarm the antibiotic.

The study appears in the Proceedings of the National Academy of Sciences.

Bacteria often engage in chemical warfare with one another, and many antibiotics used in medicine are modeled on the weapons they produce. But microbes also must protect themselves from their own toxins. The defenses they employ for protection can be acquired by other species, leading to antibiotic resistance.

The researchers focused on an enzyme, known as MccF, that they knew could disable a potent "Trojan horse" antibiotic that sneaks into cells disguised as a tasty protein meal. The bacterial antibiotic, called microcin C7 (McC7) is similar to a class of drugs used to treat bacterial infections of the skin.

"How Trojan horse antibiotics work is that the antibiotic portion is coupled to something that's fairly innocuous in this case it's a peptide," said University of Illinois biochemistry professor Satish Nair, who led the study. "So susceptible bacteria see this peptide, think of it as food and internalize it."

The meal comes at a price, however: Once the bacterial enzymes chew up the amino acid disguise, the liberated antibiotic is free to attack a key component of protein synthesis in the bacterium, Nair said.

"That is why the organisms that make this thing have to protect themselves," he said.

In previous studies, researchers had found the genes that protect some bacteria from this class of antibiotic toxins, but they didn't know how they worked. T
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2

Related biology news :

1. International team discovers gene associated with epilepsy
2. Texas A&M anthropologist discovers long-lost primate in Indonesia
3. Stowers Institutes Workman Lab discovers novel histone demethylase protein complex
4. UCSF discovers new glucose-regulating protein linked with diabetes
5. Biologist discovers pink-winged moth in Chiracahua Mountains
6. NTU professor discovers method to efficiently produce less toxic drugs using organic molecules
7. La Jolla Institute discovers novel tumor suppressor
8. IU discovers stone tools, rare animal bones -- clues to Caribbeans earliest inhabitants
9. Case Western Reserve University discovers Merkel cell originates from skin, not the neural crest
10. Iowa State University researcher discovers Ebolas deadly secret
11. CSHL-led team discovers rare mutation dramatically increasing schizophrenia risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Team discovers how bacteria resist a 'Trojan horse' antibiotic
(Date:8/1/2014)... Center for Neuroscience and Department of Psychology has ... Fellowship from the U.S. Department of Defense. The ... on learning and memory in Ranganath,s Dynamic Memory ... aims to connect neural oscillations, which are currently ... hippocampus, brain regions that are known to be ...
(Date:8/1/2014)... of phloem, the conductive tissue through which plants transport ... cylindrical cells are capped at one end by a ... which in turn form a network throughout a plant,s ... cells which play an important role in carbon sequestration, ... their differentiation," says Professor Yk Helariutta from the Institute ...
(Date:8/1/2014)... -- LiveScan Service Provider Binary Biometrics is pleased to welcome Kevin ... will improve its mobile service capabilities and add more daily appointments, which will ... service several new cities such as, but not limited to, Daytona ... Deltona , Edgewater , Holly ... Beach , Oak Hill , Orange City ...
Breaking Biology News(10 mins):Developmental regulation of important plant phloem components discovered 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 3
... on the slogan “milk does a body good,?radiologists are ... agent in gastrointestinal imaging exams—with excellent results. The researchers ... the Radiological Society of North America (RSNA). , “We ... as we see with the commonly used contrast agent, ...
... of California, San Diego and Yale University have discovered ... bacterium sprayed on crops by organic farmers to reduce ... in laboratory animals. , Their discovery, detailed in ... the National Academy of Sciences, could pave the way ...
... Estimates of increased plant respiration in response to higher ... not taken into account plants' ability to adjust to ... Laboratory. , In a Perspectives paper published April 28 ... ORNL findings suggesting that about 9 percent more carbon ...
Cached Biology News:Got inexpensive contrast agent? Milk plays new role in imaging 2Bacterial protein shows promise in treating intestinal parasites 2Bacterial protein shows promise in treating intestinal parasites 3Plants' role in global warming re-examined 2
(Date:8/1/2014)... ON (PRWEB) August 01, 2014 ... has led to a better understanding embryonic development. ... and reorganize into structurally and functionally distinct tissues ... physical defects. Prof. Todd McDevitt, Melissa Kinney, ... biophysical signals interact with biochemical cues to control ...
(Date:7/31/2014)... July 31, 2014 Today BioSpace , the leading life ... map campaign spotlighting the life sciences community in Illinois ... Kansas , Michigan , Minnesota ... Ohio and Wisconsin . ... percent of all job postings on BioSpace originating in this region in ...
(Date:7/31/2014)... (1912-1954), is famous for a number of breakthroughs, which ... he published a paper, which laid the foundation of ... computer algorithm. He next played a pivotal role in ... the German military codes, enabling the Allies to defeat ... late 1940,s he turned his attention to artificial intelligence ...
(Date:7/31/2014)... University Bloomington have described the self-assembly of large, ... potential value for the field of organic electronic ... , Their paper, "Anion-Induced Dimerization of 5-fold Symmetric ... Crystals," has been published online by Chemical ... of Chemistry. It is the first collaboration by ...
Breaking Biology Technology:Study Links Biomechanics and Gene Expression in Stem Cells 2Midwest Biotech Leaders Featured On BioSpace Map 2A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 2A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 3Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 2Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 3
... pre-registration period for the European REACH regulation (Registration, Evaluation, ... 1, 2008, SAFC Supply Solutions(R), a business segment of ... SIAL ), conducted extensive research into which products ... its capacity to supply the products deemed critical to ...
... Bulletin Board: ACEL) today reported that it has conducted ... Administration (FDA) to discuss the company,s planned submission of ... Application (NDA) for the treatment of unresectable malignant mesothelioma ... provided guidance to the company recommending that an additional ...
... Pa., Jan. 27 Encorium Group, Inc. (Nasdaq: ... contract research organization (CRO) that provides design, development, and ... many of the world,s leading pharmaceutical companies, today announced ... primarily consisting of an extension of a current U.S. ...
Cached Biology Technology:SAFC Adopts Targeted Approach to Reach Pre-Registration 2SAFC Adopts Targeted Approach to Reach Pre-Registration 3SAFC Adopts Targeted Approach to Reach Pre-Registration 4Alfacell Provides ONCONASE(R) NDA Submission Update 2Alfacell Provides ONCONASE(R) NDA Submission Update 3Encorium Group Signs $3.1 Million of New Business Contracts Including an Extension of a Current U.S. Oncology Clinical Trial with a Major Pharmaceutical Company 2Encorium Group Signs $3.1 Million of New Business Contracts Including an Extension of a Current U.S. Oncology Clinical Trial with a Major Pharmaceutical Company 3
... design in ice/water bath This CLS ... created to easily match Cornings product ... please order under the old Sigma-Aldrich ... for assistance. ID clarifier: rack and ...
... The Yeast Oligo Microarray Kit (V2), ... to simultaneously characterize expression of many ... gene activity during important biological processes. ... representing 6,256 known ORFs from the ...
... Oligo Microarray Kit (V2), 22K is useful for ... response. Each microarray contains content derived from the ... Genomic Research (TIGR) and represents 21,500 genes. ... 1 x 3? glass slides each containing an ...
... LCMSsolution software offers an intuitive, ... instrument control, diverse data handling, ... requirements. Comprehensive functions include data ... data management in both standalone ...
Biology Products: