Navigation Links
Team creates novel vaccine that produces strong immunity against cocaine high
Date:1/4/2011

LA JOLLA, CA January 4, 2011 Researchers from The Scripps Research Institute, Weill Cornell Medical College, and Cornell University have produced a long-lasting anti-cocaine immunity in mice by giving them a unique vaccine that combines bits of the common cold virus with a particle that mimics cocaine.

In their study, published January 4, 2011, in the advanced online edition of Molecular Therapy, the researchers say this novel strategy might be the first to offer cocaine addicts a fairly simple way to break and reverse their habit. The approach could also be useful in treating other addictions, such as to nicotine, heroin, and methamphetamine.

"Our very dramatic data shows that we can protect mice against the effects of cocaine, and we think this approach could be very promising in fighting addiction in humans," says the study's lead investigator, Ronald G. Crystal, chairman and professor of genetic medicine at Weill Cornell Medical College.

"The vaccine suppresses the stimulant effects of the drug," said Scripps Research Professor Kim Janda, a co-author of the paper and a pioneer in the field of developing vaccines against addictive drugs such as cocaine. "Unlike other types of treatment, a vaccine such as this one does not interfere with the neurological targets of the drug, but instead blocks cocaine from ever reaching the brain in the first place."

In the new study, the vaccine effect lasted for at least 13 weeks, the longest time point evaluated in such an approach. Since the vaccine likely will not require multiple expensive infusions, the researchers hope that it can move quickly into human trials.

Clinically, this sort of therapy could be given to people in treatment programs to aid in their recovery. And, like most other types of treatment, it will only be useful for those who want the help.

"This vaccine would be most applicable for addicts who are who are interested in getting off the dr
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Early-stage gene transcription creates access to DNA
2. MIT creates tiny backpacks for cells
3. Florida professor creates endowment for insect scientists
4. Crustacean shell with polyester creates mixed-fiber material for nerve repair
5. NYSCF Fellow lead author on study that creates blood vessel cells from stem cells
6. $15 million stimulus award creates national consortium for revealing scientific resources
7. Antarctica glacier retreat creates new carbon dioxide store
8. Bowman creates graphic translation of climate change data
9. Breeding orchid species creates a new perfume
10. Zapping Titan-like atmosphere with UV rays creates life precursors
11. Exposure to early evening sunlight in spring creates teenage night owls
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... to a new Food and Brand Lab pilot study, ... participation in the National School Lunch Program (NSLP) by ... 16%! , Chefs Move to Schools (CMTS), an initiative ... schools in order to provide nutrition instruction to students ... , A CMTS event was held in an Upstate ...
(Date:9/29/2014)... team says recently identified radiation detection properties of a ... for homeland security and medical advances. , In a ... of Optics Letters , UT Arlington Physics Professor ... to fabricate transparent nanoscintillators by heating nanoparticles composed of ... formed. A scintillator refers to a material that ...
(Date:9/29/2014)... bad rap, and understandably so. The grain-of-rice-sized insects are ... of acres in the Western U.S. and Canada over ... belief, these pests may not be to blame for ... through the region. Instead, weather and topography play a ... these bark-boring beetles. , New research led by the ...
Breaking Biology News(10 mins):Chefs move to schools can increase school meal participation and vegetable intake among students 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 3Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 2Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 3Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 4
... both crop and ornamental plants. Each year, powdery mildew and ... intense research, little is known of the plant molecules that ... European research group lead by Ueli Grossniklaus, a plant geneticist ... Science shedding a new light on mildew susceptibility ...
... parent that takes their kid out for a walk knows ... that? Do kids and small adults walk differently from taller ... Peter Weyand from Southern Methodist University, USA, is fascinated by ... goes back to Max Kleiber,s work on resting metabolic rates ...
... are getting warmer. Conservative estimates suggest that tropical areas ... the end of this century. Does global warming spell ... at the Smithsonian Tropical Research Institute, and colleagues report ... million years ago rainforests prospered at temperatures that were ...
Cached Biology News:Fertility or powdery mildew resistance? 2Fertility or powdery mildew resistance? 3New equation calculates cost of walking for first time 2New equation calculates cost of walking for first time 3Tropical forest diversity increased during ancient global warming event 2
(Date:9/30/2014)... (PRWEB) September 30, 2014 On September 11, ... James Sherley in anticipation of a session that he will ... Toxicology Summit,” scheduled for February 17-18, 2015 in London. ... Pharma IQ asked Dr. Sherley to respond to several questions ... toxicity, challenges to evaluating stem cell toxicity, and future trends ...
(Date:9/30/2014)... September 30, 2014 Whitehouse Laboratories ... chosen by the Parenteral Drug Association (PDA) ... 19, 2014) on container closure integrity testing. This lecture/laboratory ... test methods and philosophies detailed in the recently proposed ... The course will span container closure integrity ...
(Date:9/30/2014)... PA (PRWEB) September 30, 2014 ... ( IACRN), a non-profit organization based in ... Research Excellence and Safety (ACRES), a Massachusetts ... a strategic alliance agreement, setting the stage for ... to enhance clinical research quality and safety through ...
(Date:9/29/2014)... is at the forefront of diagnostics today, with ... (computerized tomography), scanning, and NMR (nuclear magnetic resonance) ... persisting problems of image resolution and quality still ... living tissue. A solution is hyperpolarization, which involves ... imaging quality by following the distribution and fate ...
Breaking Biology Technology:Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 2Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 3Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 4Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 3Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 4IACRN and ACRES to Support Clinical Research Nurses 2IACRN and ACRES to Support Clinical Research Nurses 3A safer approach for diagnostic medical imaging 2A safer approach for diagnostic medical imaging 3
... analysis results expected in Q3 2008 -, ... Therapeutics Inc.,(TSX:FXI) ("Fralex" or the "Company"), a ... today announced the,randomization of the 100th patient ... double-blind placebo-controlled randomized clinical trial,designed to assess ...
... Calif., March 10 AutoGenomics, a leader in,developing ... be among the leading healthcare and biotechnology companies ... that will be held at the,Boston Marriott Copley ... Executive Officer will present an overview of the,company, ...
... Nuclear Security Administration has awarded a $17 million cooperative ... Park to develop advanced simulations for commercial and defense ... center will focus on the behavior and reliability of ... of Excellence chosen by the NNSA. , About 35 ...
Cached Biology Technology:Fralex reaches 100th patient milestone in fibromyalgia study 2Fralex reaches 100th patient milestone in fibromyalgia study 3Purdue leads center to simulate behavior of micro-electromechanical systems 2Purdue leads center to simulate behavior of micro-electromechanical systems 3Purdue leads center to simulate behavior of micro-electromechanical systems 4
Image Acquisition and documentation system for fluorescent and non-fluorescent gels, membranes, blots, film, plates and assays...
... system is designed for multiple user laboratories ... for TLC applications. The MultiDoc-It is available ... enclosure provides a darkroom environment and protects ... Use image capture and enhancement , ...
Conveniently document gels, films and membranes with a high quality thermal printer. , Compact, footprint printer , Supplies 256 gray scale for high resolution, archive-quality thermal film prints...
Request Info...
Biology Products: