Navigation Links
Team creates genetic 'GPS' system to comprehensively locate and track inhibitory nerve cells
Date:9/21/2011

Cold Spring Harbor, NY A team of neuroscientists at Cold Spring Harbor Laboratory (CSHL) has succeeded in creating what amounts to a GPS system for locating and tracking a vital class of brain cells that until now has eluded comprehensive identification, particularly in living animals.

The cells in question are the class of neurons that release the neurotransmitter called GABA (gamma aminobutyric acid). GABA neurons function to inhibit or dial down the intensity of nerve signals propagated by excitatory neurons, which are triggered by neurotransmitters such as glutamate.

Excitatory neurons account for about 80% of all the neurons in the mammalian cortex. But without the modulatory intervention of the much rarer GABA neurons within the circuits they form, normal brain function would be impossible. Uninhibited neuronal excitation would lead to a constant state of seizure something like what is seen, episodically, in epilepsy.

Neuroanatomists have been trying to map the brain's circuitry for well over a century, but the organ's astonishing complexity anatomical and functional has insured that progress has been slow. Researchers have been able to map the entire set of circuits in the roundworm C. elegans. But that humble creature has only 302 neurons. The brains of mammals have millions of neurons, and within the tangle formed by their projections, called axons and dendrites, one finds those vital GABA cells, which until now could not be identified in any consistent way globally, throughout the mammalian brain.

CSHL Professor Z. Josh Huang and colleagues in his neuroscience lab have spent portions of the last five years working on a project to comprehensively label GABA neurons. The results of their highly time-consuming labors are described in a paper appearing Sept. 22 in the journal Neuron. The paper is likely to be influential in the neuroscience community since it describes the creation of different l
'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Early-stage gene transcription creates access to DNA
2. MIT creates tiny backpacks for cells
3. Florida professor creates endowment for insect scientists
4. Crustacean shell with polyester creates mixed-fiber material for nerve repair
5. NYSCF Fellow lead author on study that creates blood vessel cells from stem cells
6. $15 million stimulus award creates national consortium for revealing scientific resources
7. Antarctica glacier retreat creates new carbon dioxide store
8. Bowman creates graphic translation of climate change data
9. Breeding orchid species creates a new perfume
10. Zapping Titan-like atmosphere with UV rays creates life precursors
11. Exposure to early evening sunlight in spring creates teenage night owls
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 18, 2014  23andMe, Inc., the leading personal genetics company, today ... in genetic ancestry of individuals from across the ... more than four hundred years ago, the United ... peoples from different continents. This study illuminates how American history ...
(Date:12/17/2014)... Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ) has announced the ... Button Synaptics Fingerprint Sensor Technology Analysis" report to ... Based on a totally different sensing technology ... time a fingerprint sensor in its product. ...
(Date:12/17/2014)... 2014  HITLAB SM announced today its completion of ... adherence to current U.S. Food and Drug Administration (FDA) ... device and smart phone application trials utilizing the highest ... "HITLAB is determined to improve global healthcare access, quality, ...
Breaking Biology News(10 mins):23andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2
... into how a subpopulation of helper T-cells provides immunity ... offer a new means of predicting an AIDS vaccine's ... test these vaccines in clinical trials. , Led by ... the Vaccine Research Center (VRC) at the National Institute ...
... walls. And as with a house, the cell wall needs ... and allow the construction of internal components. A team from ... Research (LICR) has not only shown how the cell gets ... indicate taking away the cell's bricks and mortar is a ...
... St. Louis and their collaborators from Taiwan have examined ... have determined that the crop was domesticated independently at ... Washington University in Arts & Sciences biology doctoral candidate, ... Spencer T. Olin Professor of Biology in Arts & ...
Cached Biology News:AIDS vaccine research offers new insights on survival 2AIDS vaccine research offers new insights on survival 3Biologists find regions of rice domestication 2
(Date:1/22/2015)... Diagenode, Inc., a leading global ... and complete solutions for epigenetics research, recently launched ... the need for manual processing. The new ChIPettor ... of histones or transcription factors and a semi-automated ...
(Date:1/22/2015)... 2015  Varian Medical Systems (NYSE: VAR ), world ... its commitment to sustainability with inclusion on a prestigious list ... ranked healthcare equipment company among the Corporate Knights Global 100 ... Forum at Davos, Switzerland . ...
(Date:12/25/2014)... The report “Service Quality Management and Telco Customer ... - Global Advancements, Worldwide Forecasts & Analysis (2014-2019)” defines ... forecasting of revenues. , Browse 152 market data ... TOC on “Service Quality Management (SQM) and Telco Customer ...
(Date:12/24/2014)...  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical solutions ... the Company closed its previously announced private placement ... W. Schuler , Birchview Fund LLC and several ... offering expenses.  The proceeds will be used for ...
Breaking Biology Technology:Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Varian Honored Among World's 100 Most Sustainable Corporations 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
... (Nasdaq and SWX: BMRN) announced today the appointment,of ... Former Vice President of,Research and Development for Raven ... patents and the recipient of a,collection of prestigious ... Awards from Intellectual Property Owners, Inc., "We ...
... KNDL ), a,leading, global full-service clinical research ... Candace Kendle, PharmD,will participate in the Wachovia 2008 ... Langham Hotel in Boston, Jan. 29-31, 2008. Kendle,s,presentation ... p.m. Eastern Time., (Logo: http://www.newscom.com/cgi-bin/prnh/20030429/KNDLLOGO ...
... Phytomedics Inc., a clinical,stage biopharmaceutical company developing ... it will present at the,Wachovia 2008 Healthcare Conference ... p.m. ET., Among the topics of the ... and business developments, including Phase III development,activities related ...
Cached Biology Technology:BioMarin Appoints Dr. Gordon Vehar, Vice President of Research 2BioMarin Appoints Dr. Gordon Vehar, Vice President of Research 3Kendle to Present at the Wachovia 2008 Healthcare Conference 2
... (phospho S207) ( Abpromise for ... Antigen: Synthetic phosphopeptide derived from ... of Serine 207 (V-D-S P -V-A). ... 5608 Swiss ...
Anti-human L-Ficolin, Clone GN4, Monoclonal Antibody...
14-3-3 tau Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Applications: Western blotting Stability: Room temperature, indefinitely ...
Biology Products: