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Team awarded $7.5 million to identify potential drug candidates to treat nicotine addiction
Date:12/15/2010

tion of GABAB receptors, we can assess how these new compounds affect various behaviors in animal models. In the end, this approach has the best potential to provide potent innovative therapies for human nicotine addiction."

Scientists on the two Scripps Research campuses will collaborate in the design of new GABAB receptor modulators. The compounds will then be synthesized in California and tested in Jupiter. Key personnel from the Florida campus include Patricia McDonald and Michael Cameron, both assistant professors in the Department of Molecular Therapeutics. Compounds that successfully make it past several rounds of evaluation will be tested in animal models at UCSD.

"In many ways, this is the kind of collaboration that [Scripps Research President] Richard Lerner had in mind when he founded Scripps Florida," Finn said. "Jupiter is the state-of-the-art for assay development, chemical screening, and compound evaluation to support biomedical research in the country, possibly the world. And in La Jolla, we are developing some unique approaches to synthesis. It's a great match. This really is what everybody hoped would happen."

"This is not a typical individual investigator-driven science grant," Griffin said. "It's really a highly integrated and collaborative research program to discover innovative drug candidates. In this particular program to discover novel modulators of GABAB, the Scripps Florida team took on the translational role of a large pharmaceutical company. We are providing the framework and support to discover potent and functionally selective GABAB modulators that are efficacious in animal models of tobacco addiction. This project is very exciting and very energizing."


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Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

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