Navigation Links
Team awarded $7.5 million to identify potential drug candidates to treat nicotine addiction
Date:12/15/2010

try of the brain."

This consortium grant is a competitive renewal of a previous award to Markou, in collaboration with Novartis, when her laboratory was located at Scripps Research. Chemists at Novartis involved in the previous phase of the program discovered a number of small-molecule modulators of the GABAB receptor. Further study resulted in the development of the first highly selective positive modulators for GABAB receptors. Subsequently, work in the Markou laboratory showed that these compounds had desirable effects on nicotine dependence in animal models, while offering a better side-effect profile than other alternatives under study (full agonists at the same receptors).

"As a result, a strong preclinical proof-of-concept has already been established for this novel approach to the treatment of nicotine addiction that drives the harmful tobacco smoking habit," Markou said. "The preclinical results in our animal models are really exciting and have provided the momentum for me to continue on this project, even after Novartis indicated that it no longer wished to maintain this collaboration."

Markou reached out to her Scripps Research colleagues and formed a new research team to continue work on the initiative. "I am very fortunate to have such outstanding collaborators who are cutting-edge chemists and have extensive experience in drug discovery," she said. "After the neurobiological studies pointed out the important role of the GABAB receptor in nicotine reward, and we had positive data in a variety of animal models of nicotine dependence, it was time to focus our efforts on discovery of new molecules that could become therapeutics to assist people to quit smoking."

The new funding will advance this effort.

Griffin noted, "We want to expand the pipeline of possible compounds that could be developed into potential therapies. Once we have a better mechanistic understanding of the factors that drive selective modula
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Stevens awarded $1M for advanced biofuels research
2. L-1 Identity Solutions Awarded New Massachusetts RMV Drivers License Contract Valued at an Estimated $32 Million
3. BIO-keys(R) Law Enforcement Group Awarded $700,000 in New Contracts
4. Broad Institute awarded major grant to bolster epigenomics research
5. LSUHSC awarded patent for compound inhibiting cancer and other diseases
6. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
7. Field-hospital-on-a-chip project awarded to nanoengineer from UC San Diego
8. SAIC Awarded $37 Million Contract to Support U.S. Army Program Executive Office - Enterprise Information Systems
9. Eastman Dental Center awarded $1.6 million to find ways to prevent cavities
10. Scripps Florida scientists awarded $1.5M to fight major water and food parasites
11. BIO-key(R) Awarded PocketCop(R) Contracts From Major Law Enforcement Agencies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 2014 Research and Markets ( ... "Global Chemical Sensor Market 2015-2019" report ... http://photos.prnewswire.com/prnh/20130307/600769 One major trend upcoming ... medical sensors in biomedical applications. Chemical sensors help ... correct diagnosis during surgical procedures. The Global Chemical ...
(Date:12/15/2014)... 2014 Research and Markets ( ... "Global Facial Recognition Market 2015-2019" report ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition is a ... recognition system measures the overall facial feature of ... and the distance between eyes. Facial recognition is ...
(Date:12/11/2014)... Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the ... 2015-2019" report to their offering. ... is the adoption of multimodal biometric systems. Multimodal ... an individual for verification and identification purposes. This ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... KINGSTON, R.I. March 1, 2010 In one of ... of natural and social scientists from the University of Rhode ... among the most important factors driving the success of marine ... marine reserve is just about coral, fish and other aquatic ...
... researchers have found a way to stitch graphene and ... offers new paths of exploration for materials scientists. ... in microelectronics that scale well below the limitations of ... the lab of Pulickel Ajayan, Rice,s Benjamin M. and ...
... Moines, Iowa March 1, 2010 You may have ... bonobos living at Great Ape Trust, than you thought. And ... scientists more about the effect of culture on neurological disorders ... universal language, an alternative to spoken words to convey a ...
Cached Biology News:Scientists find community involvement, not only enforcement, drives success of marine reserves 2Rice researchers make graphene hybrid 2Rice researchers make graphene hybrid 3If bonobo Kanzi can point as humans do, what other similarities can rearing reveal? 2If bonobo Kanzi can point as humans do, what other similarities can rearing reveal? 3
(Date:12/24/2014)... , Dec. 23, 2014 China Biologic ... "Company"), a leading fully integrated plasma-based biopharmaceutical company ... that its majority-owned subsidiary, Shandong Taibang Biological Products ... certification from the China Food and Drug Administration ... facility. As previously disclosed in the Company,s public ...
(Date:12/24/2014)... , Dec. 23, 2014 Sigma-Aldrich ... that the waiting period under the Hart-Scott-Rodino Antitrust ... acquisition expired on December 22, 2014, thereby completing ... requirement for the acquisition of the Company by ... antitrust clearance satisfies another condition to closing the ...
(Date:12/22/2014)... 2014 The Center for Professional ... technical training across the life sciences industry, has partnered ... (SCDM) to provide the organization's members with discounted classroom ... to the more than 350 sessions across 80 course ... off when registering for a public course ...
(Date:12/22/2014)... CHAPEL HILL, N.C. , Dec. 22, 2014 ... ALNE) today announced that it has signed a ... biotechnology company that has developed and patented a ... and medical diagnostics products that enable rapid on-site ... and alcohol use/abuse and health issues in an ...
Breaking Biology Technology:China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3ALNE Announces Intention To Acquire BioTechPharma 2
... FRANCISCO, Oct. 2 Epiphany Biosciences,Inc. announced today ... of,Lead Director. Dr. Sanders is a highly experienced ... of Genentech.,He has also served as chief executive ... the board from 1992-1995. In addition, Dr. Sanders ...
... VIEJO, Calif., Oct. 2 Clarient, Inc.,(Nasdaq: ... testing services,resource for pathologists, oncologists and the pharmaceutical ... is featured in an,exclusive interview on WallSt.net,s 3-Minute ... overview of the company, and the,significance of the ...
... LA JOLLA, Calif., Oct. 1 TorreyPines Therapeutics, Inc.,(Nasdaq: ... successful End-of-Phase II,meeting for tezampanel with the U.S. Food ... a review of the Phase II data, the FDA ... tezampanel in acute,migraine. The FDA also confirmed that the ...
Cached Biology Technology:[video] Ronald Andrews, CEO of Clarient, Inc. Discusses Agreement With University of Pennsylvania School of Medicine on WallSt.net's 3-Minute Press Show 2TorreyPines Therapeutics Reports Successful End-of-Phase II Meeting With FDA for Tezampanel 2TorreyPines Therapeutics Reports Successful End-of-Phase II Meeting With FDA for Tezampanel 3TorreyPines Therapeutics Reports Successful End-of-Phase II Meeting With FDA for Tezampanel 4
... C-1-tetrahydrofolate synthase, cytoplasmic ... Methylenetetrahydrofolate dehydrogenase (EC ... (EC 3.5.4.9); Formyltetrahydrofolate ... [Source:Uniprot/SWISSPROT;Acc:P11586] ...
Request Info...
Lipid-rich bovine serum albumin for cell culture (1). It is chromatographically purified and has an IgG content 0.1% (w/w)....
Chicken anti-EEA1...
Biology Products: