Navigation Links
Team awarded $7.5 million to identify potential drug candidates to treat nicotine addiction
Date:12/15/2010

JUPITER, FL, December 15, 2010 For Immediate Release The Scripps Research Institute and the University of California, San Diego, (UCSD) School of Medicine have been awarded approximately $7.5 million over five years to develop novel compounds that could eventually become drug candidates for the treatment of nicotine dependence, and possibly other drug addictions. Of the funds awarded, $5 million will go to Scripps Research, $2.5 million to UCSD.

The grant from the National Institutes of Health (NIH) will fund research focused on finding novel positive modulators for GABAB receptors that have the potential to become treatments for nicotine addiction. GABAB receptors, found in the central nervous system, mediate some of the actions of GABA, the major inhibitory neurotransmitter in the brain involved in regulating several brain functions, including reward signals that play a role in drug addiction.

Consortium principal investigators are Patrick R. Griffin, chair of the Department of Molecular Therapeutics and director of the Translational Research Institute on the Jupiter, Florida campus of Scripps Research; M.G. Finn, a professor in the Department of Chemistry and the Skaggs Institute for Chemical Biology on the La Jolla, California campus of Scripps Research; and consortium director Athina Markou, a professor in the Department of Psychiatry at UCSD and adjunct professor in the Scripps Research Molecular and Integrative Neurosciences Department (MIND).

"We're looking for small molecules that will affect very complex feedback mechanisms in the brain, but in a subtle way," Finn said of the new project. "While the field has focused on some obvious receptor pathways in the brain, these are involved in many different functions and side effects are impossible to avoid. Positive modulation of GABAB receptors if we can find the right agent has strong potential to help people resist the addiction impulse without messing with the main circui
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Stevens awarded $1M for advanced biofuels research
2. L-1 Identity Solutions Awarded New Massachusetts RMV Drivers License Contract Valued at an Estimated $32 Million
3. BIO-keys(R) Law Enforcement Group Awarded $700,000 in New Contracts
4. Broad Institute awarded major grant to bolster epigenomics research
5. LSUHSC awarded patent for compound inhibiting cancer and other diseases
6. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
7. Field-hospital-on-a-chip project awarded to nanoengineer from UC San Diego
8. SAIC Awarded $37 Million Contract to Support U.S. Army Program Executive Office - Enterprise Information Systems
9. Eastman Dental Center awarded $1.6 million to find ways to prevent cavities
10. Scripps Florida scientists awarded $1.5M to fight major water and food parasites
11. BIO-key(R) Awarded PocketCop(R) Contracts From Major Law Enforcement Agencies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... An international team of scientists including researchers from the University ... commonly known as canolain the journal Science . Their ... which is used widely in farming and industry. , ... Europe, but the winter crop is increasingly cultivated in Georgia. ... low levels of saturated fat and rich supply of omega-3 ...
(Date:8/21/2014)... Conn. , Aug. 21, 2014 Nxt-ID, ... the growing mobile commerce market, announced today that its ... common stock to be issued in its proposed underwritten ... approved for listing on The Nasdaq Capital Market, subject ... the common stock and warrants, and will trade under ...
(Date:8/21/2014)... and other itchy, flaky maladies in humans has now ... reefs and the extreme environments of arctic soils and ... journal PLOS Pathogens considers the diversity, ecology, ... Malassezia in light of new insights gained from ... University of Hawai,i at Mānoa scientist Anthony Amend discovered ...
Breaking Biology News(10 mins):Canola genome sequence reveals evolutionary 'love triangle' 2Nxt-ID Approved for NASDAQ Capital Market Listing 2Nxt-ID Approved for NASDAQ Capital Market Listing 3From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2
... to grow iron-oxidizing bacteria using electricity instead of iron, an ... and could one day be used to turn electricity into ... mBio , the online open-access journal of the American ... supplies these bacteria with a steady supply of electrons that ...
... LIVERMORE, CALIF. A new way of looking at ... in the cell membrane, changing the understanding of its ... from Lawrence Livermore National Laboratory, the University of Illinois ... relationships among molecules within cell membranes. Their ...
... release is available in German . ... nervous system has an astonishing capacity for regeneration following ... Medicine in Gttingen have discovered that, following nerve damage, ... makes an important contribution to the regeneration of damaged ...
Cached Biology News:Scientists trick iron-eating bacteria into breathing electrons instead 2New look at cell membrane reveals surprising organization 2New look at cell membrane reveals surprising organization 3Glial cells assist in the repair of injured nerves 2
(Date:8/21/2014)... , Aug. 21, 2014  BioSpecifics Technologies Corp. ... developing first in class collagenase-based products marketed as ... in the U.S. and XIAPEX ® in ... from a randomized, double-blind Phase 2a study of ... edematous fibrosclerotic panniculopathy. The results showed that all ...
(Date:8/21/2014)... DESY scientists has observed tiny quantum vortices in cold ... journal Science that the exotic vortices arrange ... is the first time that the quantum vortices, which ... is known as superfluid helium, have been detected in ... Andrey Vilesov of the University of Southern California, one ...
(Date:8/21/2014)... His Majesty Willem-Alexander, King of the Netherlands ... His Majesty Willem-Alexander, King of the Netherlands, has announced ... POET-DSM Advanced Biofuels’ Project LIBERTY cellulosic ethanol plant in ... will take part in the Grand Opening Ceremony to ... p.m. and tour the plant. POET-DSM is a joint ...
(Date:8/21/2014)... 21, 2014  Decision Resources Group finds that ... and Mexico currently ... newly approved agents, the anticipated label extension of ... launch of emerging biologics will substantially increase the ... emerging IL-5 inhibitors will introduce a new dynamic to ...
Breaking Biology Technology:BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 4BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 5Scientists observe quantum vortices in cold helium droplets 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3
... MILWAUKEE--- GE Healthcare , a $10 billion provider ... information technology, announced today that it has received ... healthcare industry authority, KLAS Enterprises for the second ... called Centricity(R) Pharmacy Information System, was recognized in ...
... OASYS , a leading developer of K-12 software ... Behind management, recently announced their online, ASP software ... (IEPs) and monitors the progress of children with ... in 16 Wisconsin school districts during 2003, provides ...
... Third Wave Technologies Inc , a maker of molecular ... 2D6 analysis panel, which provides clinical trial laboratories with ... for the important 2D6 gene. , ,The panel is ... the ability to configure custom assay panels. The panel ...
Cached Biology Technology:Third Wave Releases Gene Test 2