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Tau-induced memory loss in Alzheimer's mice is reversible
Date:2/16/2011

reversed in principle - at least at an early stage of the illness before too many neurons have been destroyed," explains Eva Mandelkow who, together with her husband, will be awarded the Potamkin Prize 2011 for Alzheimer's disease research, which is sponsored by the American Academy of Neurology.

The aggregation of tau proteins, however, cannot simply be switched off in humans the way it can in the transgenic mice. Nevertheless, special substances exist that could dissolve the tau aggregates. By screening 200,000 substances, the Hamburg researchers have already identified several classes of active substances that could re-convert the tau aggregates into soluble tau. These are now being tested on animals.


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Contact: Eva-Maria Mandelkow
eva.mandelkow@mpasmb.desy.de
49-408-998-2810
Max-Planck-Gesellschaft
Source:Eurekalert

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