Navigation Links
Targeting metabolism to develop new prostate cancer treatments
Date:2/27/2014

ing metabolic-targeted therapies directed toward this signaling cascade for the treatment of prostate cancer, and we look forward to exploring this and other metabolic pathways further in order to develop the next generation of cancer therapies."

In their studies, Frigo's team showed that prostate cancer cells respond to androgens not only by increasing the breakdown of sugars, a process known as glycolysis that is commonly seen in many cancers, but also escalating the metabolism of fats. While much of the research on cancer metabolism has historically focused on glycolysis, the researchers say it's now becoming apparent that not all cancers depend solely on sugars.

Their findings further indicate that the metabolic changes brought about by the AMPK enzyme result in distinct growth advantages to prostate cancer cells. They say, however, that our understanding of how androgen receptor signaling impacts cellular metabolism and what role this has in disease progression remains incomplete.

The Frigo lab is one of several within the CNRCS concentrated on the role of nuclear receptors in cancer prevention and treatment, and his team has long studied the androgen receptor, which turns on or off various signaling pathways. Frigo believes these pathways hold the potential for better cancer treatments. Targeting these underexplored metabolic pathways for the development of novel therapeutics, Frigo's ultimate goal is to unlock more effective and less harmful cancer treatment alternatives.

With funding from the Department of Defense, National Institutes of Health, Texas Emerging Technology Fund and Golfers Against Cancer, Frigo's latest research appears in Nature's Oncogene. One of the world's leading cancer journals, Oncogene covers all aspects of the structure and function of genes that have the potential to cause cancer and are often mutated or expressed at high levels in tumor cells.


'/>"/>

Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Going against the flow: Halting atherosclerosis by targeting micro RNA
2. Targeting evolution: Could this be the next strategy to stop superbugs?
3. Targeting cancers sweet tooth
4. Honey bee gene targeting offers system to understand food-related behavior
5. U of M researchers develop model for better testing, targeting of MPNST
6. Therapies for ALL and AML targeting MER receptor hold promise of more effect with less side-effect
7. Signalling pathways meeting targeting the HER/EGFR family: Focus on breast, lung and colorectal cancers
8. Research improving breast cancer treatment by targeting tumor initiating cells
9. Cancer Cell article shows first evidence for targeting of Pol I as new approach to cancer therapy
10. Targeting tuberculosis hotspots could have widespread benefit
11. Nanobubbles plus chemotherapy equals single-cell cancer targeting
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Targeting metabolism to develop new prostate cancer treatments
(Date:12/17/2014)... Valencell, a leader in performance biometric data ... industry leaders such as Intel, Jabra, Atlas, and Scosche ... products. These products will be showcased at CES 2015, ... . "Our partners choose PerformTek ... – with the clinical data to back it up," ...
(Date:12/17/2014)... , Dec. 16, 2014  Automation is ... this more evident than at international borders. Over ... document scanners have allowed veteran travelers to self ... Passport Control (APC) Kiosks at an increasing number ... globe. According to Maxine ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced ... the APAC Region 2015-2019"  report to their offering. ... this market is advances in technology. With continuous ... biometric solutions to the latest standard that meets ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... scanner aboard the international space station has been taking new ... it was launched, providing scientists with a new set of ... spills to plankton blooms. The images and other data ... an online clearinghouse coordinated by Oregon State University. Additional ...
... FLAGSTAFF, Ariz. Temperature increases resulting from climate change in ... of their current range in 60 to 90 years, according ... Ken Cole. The research team used models of future ... in its current range, and the fossil record to project ...
... has shown that reducing the concentration of carbon ... a wetter climate in the short term. New ... and Ken Caldeira offers a novel explanation for ... (CO2) concentrations are decreasing. Their findings, published online ...
Cached Biology News:Data streaming in from Space Station to OSU lab 2Data streaming in from Space Station to OSU lab 3Uncertain future for Joshua trees projected with climate change 2Cutting carbon dioxide helps prevent drying 2
(Date:12/19/2014)... , Dec. 19, 2014 Naurex Inc., a ... drugs for diseases of the central nervous system, today ... chief executive officer, will present at the 33 rd ... will take place at 3:00 p.m. PST on Tuesday, ... San Francisco, Calif. ...
(Date:12/19/2014)... , Dec. 19, 2014 Decision Resources ... will grow at a 12 percent compound annual growth ... of the aging population and the increasing adoption of ... America will also spur demand for dental ... dental implant and periodontal treatments. Other key ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 Today, ... locate its pilot production facility and future company ... and produce innovative new materials that safely and ... not only because of its historic, strong support ... efforts to attract leading edge, technology-based companies such ...
(Date:12/19/2014)... Reports from CDC show approximately ... one or more chronic health conditions - including cardiovascular ... some of these diseases, but may not eliminate the ... While implanted nerve stimulation devices today offer relief, they ... can induce side effects. , To eliminate the ...
Breaking Biology Technology:Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 4Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2
... May 13, 2011 Soligenix, Inc. (OTCBB: SNGX) (Soligenix ... its financial results for the first quarter of 2011. ... of 2011 were approximately $808,000 as compared to $336,000 ... were primarily a result of increases in National Institutes ...
... Scientists at the U.S. Department of Energy,s Brookhaven National ... a novel form of carbon, contributing to an explanation ... sponge when it comes to soaking up electric charge. ... of Texas - Austin, can be incorporated into "supercapacitor" ...
... report commissioned by the U.S. Department of Energy has ... of producing hydrogen fuel from sunlight is the only ... meet future cost targets set by the federal agency. ... Alan Weimer,s research team of CU-Boulder,s chemical and biological ...
Cached Biology Technology:Soligenix Reports First Quarter 2011 Financial Results and Reviews Accomplishments 2Soligenix Reports First Quarter 2011 Financial Results and Reviews Accomplishments 3Soligenix Reports First Quarter 2011 Financial Results and Reviews Accomplishments 4Soligenix Reports First Quarter 2011 Financial Results and Reviews Accomplishments 5Activated graphene makes superior supercapacitors for energy storage 2Activated graphene makes superior supercapacitors for energy storage 3CU method projected to meet DOE cost targets for solar thermal hydrogen fuel production 2
... SpeedVac™ Concentrators set the standard for sample concentration ... with large chamber uses a combination of centrifugal ... in a single run. , SC210A comes equipped ... for long lasting chemical compatibility ...
Digital display of time, vacuum and temperature , Dual vacuum control of ramping rate and ultimate level , Comes complete with RH40-12 (40 x 1.5 ml) Rotor and (2) Glass Condensation Flasks. ...
... series of vacuum concentrators/centrifugal evaporators offers a ... to rapid and safe concentration of heat-labile ... with oil-free or high vacuum pumps, a ... selection of rotors (eliminating sample loss by ...
... George Paxinos Affiliation: School of Psychology, The University ... Affiliation: Curtin University of Technology, Perth, Australia This ... of the rat brain. It is a ... revison and extension of the compact 3rd edition. ...
Biology Products: