Navigation Links
Targeting leg fatigue in heart failure
Date:10/31/2011

Doctors should not only treat the heart muscle in chronic heart failure patients, but also their leg muscles through exercise, say researchers in a study published today in the Journal of Applied Physiology.

Heart failure causes breathlessness and fatigue that severely limits normal daily activities such as walking. The University of Leeds research team has, for the first time, shown that leg muscle dysfunction is related to the severity of symptoms in heart failure patients. These findings suggest that daily activity in patients with severe heart failure may not simply be limited by the failing heart, but also by an impairment in the leg muscles themselves.

In a series of experiments with chronic heart failure patients, the research team measured responses of the heart, lungs and leg muscles following a moderate exercise warm-up. Using a near-infrared laser to measure the oxygenation of the leg muscles, they found that warm-up exercise increased the activity of skeletal muscle enzymes that control energy production. However, this adaptation was less in patients with the most severe symptoms, showing that the heart failure condition had a negative impact on the normal function of the leg muscles.

Dr Harry Rossiter, of the University's Faculty of Biological Sciences says: "Many chronic heart failure patients complain of leg fatigue during exercise and this can prevent them from being active. Our study shows that by warming up properly, patients can improve the oxygenation and performance of their leg muscles, which is beneficial in promoting exercise tolerance."

"When your muscles don't use oxygen well, it causes an uncomfortable burning sensation during activity," says Dr Klaus Witte, the Leeds General Infirmary Cardiologist on the research team. "The effect of a warm up is to direct oxygen to the places that are going to need it, and make the muscles ready to use it when you start exercising."

Dr Rossiter says the next stage of this research will be to see whether training of the skeletal muscles can improve long-term overall outcomes for patients with chronic heart failure, and to discover more about the pathological changes in the leg muscles that may be a contributing factor in limiting exercise.

"Our main message is that exercise is safe and beneficial in patients with heart failure. By warming up the leg muscles properly, the exercise can be more comfortable and sustained for longer - affording great benefits for these patients," he says.


'/>"/>

Contact: Clare Elsley
clare@campuspr.co.uk
44-113-357-2102
University of Leeds
Source:Eurekalert

Related biology news :

1. Targeting HIVs sugar coating
2. Researchers publish study on neuronal RNA targeting
3. Government-led efforts targeting eating habits of children needed to curb worldwide obesity epidemic
4. Targeting a cure: Research looks at developing a bulls-eye therapy to combat lung cancer
5. TREW Marketing Introduces Smart Marketing for Engineers, a Free Guidebook for Small Businesses Targeting Technical Audiences
6. Heart Failure: Targeting the right patients for CRT-D
7. The aging brain and Alzheimers disease: New ideas for targeting synaptic dysfunction
8. Putting a bulls-eye on the flu: Paper details influenzas structure for future drug targeting
9. Tool allows precise targeting of radiotherapy for cancer radiation therapy
10. Targeting a waterborne foe
11. Peregrine reports new study from Duke shows anti-HIV potential of targeting PS on cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... Feb. 2, 2016 Checkpoint Inhibitors for ... Market Are you interested in the future ... for checkpoint inhibitors. Visiongain,s report gives those predictions ... and national level. Avoid falling behind in ... opportunities and revenues those emerging cancer therapies can ...
(Date:2/1/2016)... -- Rising sales of consumer electronics coupled ... gesture control market size through ... electronics coupled with new technological advancements to drive global ... through 2020   --> Rising ... to drive global touchfree intuitive gesture control market ...
(Date:1/27/2016)... Ohio , Jan. 27, 2016  Rite Track, ... based in West Chester, Ohio ... award winning service staff, based in Austin, ... capacity and ability to provide modifications, installations and technical ... Dovalina , CEO of PLUS, commented, "PLUS has provided ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... , Feb. 10, 2016 NX Prenatal ... its proprietary NeXosome® technology for early warning of ... its most recent study by Dr. Thomas ... the Society for Maternal Fetal Medicine,s (SMFM) annual meeting ... 1-6 th , 2016.  The presentation reported initial ...
(Date:2/10/2016)... Feb. 10, 2016  Matchbook, Inc., a company ... growing biotech companies, announced today the appointment of ... Advisor. Jim brings nearly 25 years of experience ... having spent nearly two decades in executive level ... Procurement at Genzyme and, most recently headed global ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... research registry built on the secure online PatientCrossroads platform, has exceeded both its ... participants have joined the PROMPT study, which seeks to advance understanding of the ...
(Date:2/9/2016)... ... February 09, 2016 , ... With a presidential election ... Health Care Business Conference will bring together over 500 top healthcare leaders for a ... in transformation. The conference, organized by MBA students of the University of Pennsylvania’s Wharton ...
Breaking Biology Technology: