Navigation Links
Targeting cancer with a triple threat
Date:4/15/2014

drug, doxorubicin, was designed so that it would be released only when ultraviolet light shines on the particle. Once all three drugs are released, all that is left behind is PEG, which is easily biodegradable.

Working with researchers in the lab of Paula Hammond, the David H. Koch Professor of Engineering and a member of MIT's Koch Institute for Integrative Cancer Research, the team tested the particles against ovarian cancer cells grown in the lab. Particles carrying all three drugs killed the cancer cells at a higher rate than those that delivered only one or two drugs.

Johnson's lab is now working on particles that carry four drugs, and the researchers are also planning to tag the particles with molecules that will allow them to home to tumor cells by interacting with proteins found on the cell surfaces.

Johnson also envisions that the ability to reliably produce large quantities of multidrug-carrying nanoparticles will enable large-scale testing of possible new cancer treatments. "It's important to be able to rapidly and efficiently make particles with different ratios of multiple drugs, so that you can test them for their activity," he says. "We can't just make one particle, we need to be able to make different ratios, which our method can easily do."


'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Targeting enforcement where needed most in Africas heart of biodiversity
2. New therapies targeting cancer, Alzheimers goal of UH physicist
3. UTMB collaborates on program targeting potential bioterrorist pathogens Ebola and Marburg
4. Targeting metabolism to develop new prostate cancer treatments
5. Going against the flow: Halting atherosclerosis by targeting micro RNA
6. Targeting evolution: Could this be the next strategy to stop superbugs?
7. Targeting cancers sweet tooth
8. Honey bee gene targeting offers system to understand food-related behavior
9. U of M researchers develop model for better testing, targeting of MPNST
10. Therapies for ALL and AML targeting MER receptor hold promise of more effect with less side-effect
11. Signalling pathways meeting targeting the HER/EGFR family: Focus on breast, lung and colorectal cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... DETROIT In order to support the world,s ... chemicals, polymers and more, new and more efficient ... team of researchers, including several from Wayne State ... of a new grant from the National Science ... Guided Design of Multicomponent Materials for Electrocatalytic Cascade ...
(Date:9/29/2014)... received a five-year, $6 million grant for clinical ... and development of safe and effective treatments for ... the National Institutes of Health, National Institute on ... Medication Development for Cocaine Use Disorder to oversee ... decisions on moving forward with more expensive large-scale ...
(Date:9/29/2014)... published online in Behavioral Brain Research provides ... as a result of chronic alcohol exposure that can ... Clinical assessments and research indicate that individuals with alcohol ... can occur when people are actively drinking, when they ... , "Sleep-wake disturbances can last for months, or ...
Breaking Biology News(10 mins):Wayne State research aims to develop new, more efficient catalytic materials 2New VCU center to target cocaine addiction 2
... Adolescents who diet and develop disordered eating behaviors ... carry these unhealthy practices into young adulthood and beyond, ... researchers and published in the July 2011 issue of ... "The findings from the current study argue for ...
... University of Illinois researchers identified the top pathogens, pests ... in Food Security. Soybean aphid, soybean rust, soybean cyst ... pathogen, red leaf blotch, were featured as some of ... now and in the future. "Enormous potential exists ...
... HOUSTON (June 23, 2011) The remoteness ... to astronaut health care. One solution is ultrasound. ... (NSBRI) have developed tools that expand the use of ... and underserved locations. These tools include techniques that streamline ...
Cached Biology News:Adolescents' dieting and disordered eating behaviors continue into young adulthood 2Adolescents' dieting and disordered eating behaviors continue into young adulthood 3New and old threats to soybean production 2Space research gives birth to new ultrasound tools for health care in orbit, on Earth 2Space research gives birth to new ultrasound tools for health care in orbit, on Earth 3Space research gives birth to new ultrasound tools for health care in orbit, on Earth 4
(Date:9/30/2014)... NEW YORK , Sept. 30, 2014 /PRNewswire/ ... used to kill nematodes. Nematodes are microscopic parasitic ... soil, water, and inside other plants and animals. ... high volatility or other properties promoting migration through ... contain more than 1,000 plant-parasitic nematodes. With more ...
(Date:9/30/2014)... 30, 2014 Proove Biosciences , ... excited to announce a new genetic test built upon ... Pain Perception Test will provide physicians with an ... pain tolerance levels are stratified between individuals. With this ... a person has a genetic predisposition that will affect ...
(Date:9/30/2014)... Sept. 30, 2014  RegeneRx Biopharmaceuticals, Inc. (OTC: ... it has received a Canadian Patent for Inhibition ... This patent includes claims using thymosin beta 4, ... peptides for these purposes.  The patent will expire ... Inc. ( www.regenerx.com ) RegeneRx ...
(Date:9/30/2014)... Fast, semi-automatic creation of ... documents ChemAxon , a leader ... for life science research, launches ChemCurator, an application ... from documents. Markush structures are essential ... and understanding Markush structures is a difficult and ...
Breaking Biology Technology:Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 3RegeneRx Receives Canadian Patent for Inhibition or Reversal of Skin Aging 2ChemAxon Introduces ChemCurator for Chemical Information Extraction and Markush Structure Creation 2
... SuperPower, University of Houston, Oak Ridge National Laboratory and ... smart grid demonstration project award announced by U.S. Department ... funds will be used to manufacture a transformer for ... nation,s power grid. , "The project is for ...
... SHANGHAI, Dec. 22 /PRNewswire-Asia/ -- Sundia MediTech, a leading,pharmaceutical ... has received 2009 Deloitte Technology Fast 500 Asia Pacific award.,This ... news was,announced at a ceremony on December 10, 2009 at ... The Deloitte Technology Fast 500 Asia Pacific program is now ...
... , www.bioheartinc.com , The Bioheart ... large quantity of stem cells can be obtained from a patient,s ... cheaply. Adipose stem cells are capable of promoting blood vessel ... Lower limb ischemia is pain, often severe enough to be intolerable, ...
Cached Biology Technology:Waukesha Electric partners with SuperPower and UH to build fault current limiting superconducting transformer for Dept. of Energy 2Waukesha Electric partners with SuperPower and UH to build fault current limiting superconducting transformer for Dept. of Energy 3Bioheart Makes Breakthrough in Critical Limb Ischemia Therapy with Stem Cells Obtained from Fat Tissue 2Bioheart Makes Breakthrough in Critical Limb Ischemia Therapy with Stem Cells Obtained from Fat Tissue 3Bioheart Makes Breakthrough in Critical Limb Ischemia Therapy with Stem Cells Obtained from Fat Tissue 4Bioheart Makes Breakthrough in Critical Limb Ischemia Therapy with Stem Cells Obtained from Fat Tissue 5
... Molecular Probes is pleased to offer ... the ultrasensitive detection of primary amines. ... Indiana University, the ATTO-TAG reagents are ... (OPA), naphthalene-2,3-dicarboxaldehyde (NDA) and anthracene-2,3-dicarboxaldehyde, all ...
...
Microlite 1+ 1x12 Strip assembled, flat bottom; the ideal vessel for low signal luminescent reactions, offering medium binding with enhanced dynamic range, extra high reflectivity and minimal cross t...
... Software is the ultimate tool for ... handling. There are two editions of ... for scientists working in life science ... offering features needed for compliance with ...
Biology Products: