Navigation Links
Targeting a waterborne foe
Date:4/25/2010

ANAHEIM, CA Discovered in 1976, cryptosporidium lurks worldwide in water, contaminating swimming pools, water parks, and drinking water supplies. Although it has even been featured on the comedy show The Colbert Report, it is no laughing matterthis microscopic pathogen is a leading cause of diarrhea and malnutrition and the most common source of infection in immune-weakened people such as AIDS patients. It is also a potential bioterrorism agent.

"All you need is a cow and a centrifuge to harvest enough oocysts to infect a small city," says Brandeis University biochemist Liz Hedstrom. Roughly 20 percent of calves are infected by cryptosporidium oocysts, which are found in their feces. In 1993, in the largest waterborne disease outbreak in U.S. history, this nasty protozoan parasite infiltrated Milwaukee's municipal water supply, killing more than 100 people and sickening some 400,000.

Cryptosporidium invades the small intestine, where it opens fire, typically causing severe gastrointestinal distress and even death in people with weakened immune systems. Cryptosporidium is a hardy foe whose oocystsa spore-like phase in the parasite life cycleremain stable outside a host for long periods and are resistant to conventional water treatment such as chlorine disinfection.

The latest research news on this waterborne foe will be the focus of Hedstrom's talk, titled "Targeting a prokaryotic protein in a eukaryotic parasite," at the American Society for Biochemistry and Molecular Biology's annual meeting. The talk will be held in the Anaheim Convention Center, Room 304C, on Sunday April 25 at 9:55 am PST. Hedstrom's promising research could lead to an effective treatment to prevent cryptosporidiosis.

Hedstrom and her collaborators made a critical breakthrough in eroding cryptosporidium defenses when they identified IMPDH, a key enzyme involved in the biosynthesis of RNA and DNA, as a potential drug target. Her research has shown that IMPDH inhibitors block the parasite from proliferating in vitro. Importantly, the Cryptosporidium IMPDH has very different properties from those of the human enzyme counterpart.

Next, Hedstrom and her colleagues identified compounds that blocked the action of the Cryptosporidium IMPDH, but spared human IMPDH. Leading a large-scale screen of a commercial library containing 129,000 compounds, Hedstrom discovered more than fifty compounds that specifically inhibit the parasite enzyme. A number of these compounds display antiparasitic activity. Hedstrom is now working on improving the compounds' potency, bioavailability and metabolic stability, a first step in the drug development process.

"It's a difficult problem, but we think that we have some very promising compounds," says Hedstrom.


'/>"/>

Contact: Nicole Kresge
nkresge@asbmb.org
202-316-5447
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Peregrine reports new study from Duke shows anti-HIV potential of targeting PS on cells
2. Advances reported in quest for drugs targeting childhood cancer
3. Lose the fat: Targeting grease to curtail sewer overflows
4. Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers
5. UCLA researchers discover new molecular pathway for targeting cancer, disease
6. Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease
7. Targeting children effective use of limited supplies of flu vaccine and could help control flu spread
8. Peregrines PS-targeting antibodies highlighted in AACR Annual Meeting studies
9. Twin nanoparticle shown effective at targeting, killing breast cancer cells
10. Motor nerve targeting to limb muscles is controlled by ephrin proteins
11. AACR annual meeting showcases developments in understanding and targeting cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)... 2016  A new partnership announced today will ... decisions in a fraction of the time it ... high-value life insurance policies to consumers without requiring ... Force Diagnostics, rapid testing (A1C, Cotinine and HIV) ... pressure, weight, pulse, BMI, and activity data) available ...
(Date:3/31/2016)... , March 31, 2016   ... ("LegacyXChange" or the "Company") LegacyXChange is excited ... of its soon to be launched online site for ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders a ... DNA technology to an industry that is notorious for ...
(Date:3/22/2016)... March 22, 2016 ... Sensors Market for Consumer Industry by Type (Image, ... Application (Communication & IT, Entertainment, Home Appliances, ... Forecast to 2022", published by MarketsandMarkets, the ... to reach USD 26.76 Billion by 2022, ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... May 25, 2016 , ... The Ankle Plating System ... designed to address fractures of the distal tibia and fibula. This system marks ... Plating System 3 is composed of seven plate families that span the lateral, ...
(Date:5/25/2016)... ... 2016 , ... The American Medical Informatics Association (AMIA) responded ... Coordinator for Health IT (ONC) outlining a measurement approach to interoperability that focuses ... and where it was needed. The organization of health informatics professionals said a ...
(Date:5/25/2016)... ... 25, 2016 , ... WEDI, the nation’s leading authority on the use of ... Stellar has been named by the WEDI Board of Directors as WEDI’s president and ... leader with more than 35 years of experience in healthcare, association management and organizational ...
(Date:5/25/2016)... ... 25, 2016 , ... Biohaven Pharmaceutical Holding Company Ltd. (Biohaven) ... company’s orphan drug designation request covering BHV-4157 for the treatment of Spinocerebellar Ataxia ... , Spinocerebellar ataxia is a rare, debilitating neurodegenerative disorder that is estimated ...
Breaking Biology Technology: