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Targeted drug therapy prevents exercise-induced arrhythmias
Date:3/29/2009

flecainide is going to allow us to back off the excessively high doses of beta blockers, limit defibrillator discharges in patients with ICDs, and decrease the likelihood that we'll need to implant defibrillators in these patients at a young age if the arrhythmias can be controlled medically," Fish said. "That's an exciting prospect."

Fish feels like he's come full circle with flecainide. In the late 1980s, he surveyed the drug's effects in pediatric patients as a follow-up to a large clinical trial in adults that showed increased rates of death among heart attack survivors who had ventricular arrhythmias. Fish and his colleagues found an unexpectedly high frequency of pro-arrhythmia among young patients.

"So for 20 years, physicians have been reluctant to use flecainide for ventricular arrhythmias," Fish said. "It's interesting to now find ourselves turning to a medication we've been fearful of using. In this specific population (CPVT patients), it may turn out to be the magic bullet."


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Contact: Craig Boerner
craig.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

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