Navigation Links
Targeted blocking of cell death prevents fatal condition septic shock
Date:12/27/2011

Ghent, Belgium 27 December 2011 - Researchers of VIB and UGent have discovered a new approach to preventing septic shock, an often fatal extreme inflammatory reaction of the body. It is the most frequent cause of death at intensive care departments in hospitals. In sepsis, acute inflammation is attended by low blood pressure and blood clots, causing the organs to stop working. Only recently, the Brazilian football legend Socrates, died of the consequences of this condition. In a new study in the top journal Immunity, Peter Vandenabeele and colleagues of VIB-UGent described how blocking a particular form of cell death (necroptosis) fully protects mice against this fatal inflammation.

"This research opens up new perspectives for the treatment of fatal inflammatory diseases such as sepsis," says researcher Peter Vandenabeele of VIB and UGent. "By blocking necroptosis, we have found a possibly new target for a therapy."

Sepsis and SIRS

The Ghent scientists studied the Systemic Inflammatory Response Syndrome (SIRS). This is a severe inflammatory reaction affecting the entire body. It may be caused by an infection, such as sepsis, or by physical injury such as severe burns or a serious road accident.

Role of TNF in SIRS

The cytokine tumor necrosis factor (TNF) plays a crucial role in the occurrence of SIRS. The presence of TNF may trigger the cells to cause inflammation and programmed cell death. Inflammation is a necessary response in the body generated, among other things, to prevent or restore damage when injury and infections have been sustained. Programmed cell death can occur in two ways: via apoptosis or via necroptosis. The difference between the two forms of cell death lies among other things in communication with our immune system. Necroptosis usually provokes a strong reaction by the immune system whereas apoptosis proceeds unnoticed.

RIPK: potential therapeutic target for treatment of SIRS and sepsis

Peter Vandenabeele and his colleagues Linde Duprez, Nozomi Takahashi and Anje Cauwels have discovered that in mice eliminating apoptosis did not have any impact on lethal SIRS whereas eliminating nepcroptosis afforded full protection against the condition. The scientists managed to block nepcroptosis by eliminating RIPK (Receptor-interacting serine/threonine-protein kinase) molecules. The experiments showed that RIPK plays a crucial role in SIRS and sepsis. The molecule appears to constitute a potential therapeutic target for the treatment of SIRS and sepsis. Further research should clarify the potential applications of this discovery.


'/>"/>

Contact: Joris Gansemans
joris.gansemans@vib.be
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Related biology news :

1. Targeted antibacterial proteins may offer antibiotic alternative
2. GNS Healthcare Collaborates with NCI in New Approach to Lung Cancer; Supercomputer Analysis to Aid in Matching Targeted Drugs to Patients
3. GNS Healthcare Collaborates with NCI in New Approach to Lung Cancer; Supercomputer Analysis to Aid in Matching Targeted Drugs to Patients
4. Targeted adalimumab treatment can optimize long-term outcomes for patients with early RA
5. Lesser-known Escherichia coli types targeted in food safety research
6. Delivering drugs to the brain: New research into targeted treatment of Alzheimers
7. New targeted therapy adds benefit to erlotinib in some patients with advanced lung cancer
8. New mechanisms of tumor resistance to targeted therapy in lung cancer are discovered
9. UC to test targeted treatment for prostate cancer
10. Caltech-led team provides proof in humans of RNA interference using targeted nanoparticles
11. New subtype of breast cancer responds to targeted drug
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... April 5, 2017  The Allen Institute for Cell ... Explorer: a one-of-a-kind portal and dynamic digital window into ... data, the first application of deep learning to create ... cell lines and a growing suite of powerful tools. ... these and future publicly available resources created and shared ...
(Date:4/4/2017)... --  EyeLock LLC , a leader of iris-based identity ... and Trademark Office (USPTO) has issued U.S. Patent No. ... iris image with a face image acquired in sequence ... th issued patent. "The issuance ... multi-modal biometric capabilities that have recently come to market ...
(Date:3/30/2017)... The research team of The Hong Kong Polytechnic University ... adopting ground breaking 3D fingerprint minutiae recovery and matching technology, pushing ... for use in identification, crime investigation, immigration control, security of access ... ... A research team led by Dr Ajay ...
Breaking Biology News(10 mins):
(Date:8/11/2017)... ... August 11, 2017 , ... ... in particular, more natural alternatives to synthetic ingredients,” said Matt Hundt, President of ... with the established manufacturing presence and know-how of Biorigin will allow us to ...
(Date:8/10/2017)... ... August 09, 2017 , ... The era of using ... here. The team at Capricor Therapeutics, Inc. utilized a cardiosphere-derived stem-like cell culturing ... , Dr. Travis Antes, head of analytical development at Capricor Therapeutics Inc., will ...
(Date:8/10/2017)... ... August 09, 2017 , ... SPIE, the ... laboratories — the Wellman Center for Photomedicine, the Manstein Lab in the Cutaneous ... Beckman Laser Institute at University of California, Irvine — and the Hillenkamp family ...
(Date:8/10/2017)... ... August 10, 2017 , ... ... market news outlet had initiated coverage on Next Group Holdings, Inc. and see's ... consumer markets geared toward those that cannot engage in traditional banking services. According ...
Breaking Biology Technology: